Catalog No.
EHD72002
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu98-Leu231
Predicted molecular weight
18.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P26717
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NKG2-C type II integral membrane protein, CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor, CD159c, KLRC2, NKG2C
Adaptive NKG2C+ NK cells in cytomegalovirus seropositive individuals predominantly lack NKR-P1A receptor expression., PMID:40426298
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
Association Between NK Cell Genetic Variants and the Development of Long COVID Associated- and Prepandemic Small Fiber Neuropathy., PMID:39610330
NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV., PMID:39581700
NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control., PMID:39288262
A human autoimmune organoid model reveals IL-7 function in coeliac disease., PMID:39048815
SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression., PMID:38804979
Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence., PMID:38736873
NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment., PMID:38700066
Lingering Effects of Early Institutional Rearing and Cytomegalovirus Infection on the Natural Killer Cell Repertoire of Adopted Adolescents., PMID:38672472
Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data Reveals Memory-like NK Cell Subset Associated with Mycobacterium tuberculosis Latency., PMID:38391906
Deciphering the immune landscape of head and neck squamous cell carcinoma: A single-cell transcriptomic analysis of regulatory T cell responses to PD-1 blockade therapy., PMID:38096229
Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis., PMID:38040543
A novel immune-related gene signature for predicting immunotherapy outcomes and survival in clear cell renal cell carcinoma., PMID:37919459
Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells., PMID:37901227
Post-Acute Myocardial Infarction Heart Failure Core Genes and Relevant Signaling Pathways., PMID:37678296
Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression., PMID:37534375
Characterization of large-scale genomic differences in the first complete human genome., PMID:37403156
Association between NKG2/KLR gene variants and epilepsy in Autism Spectrum Disorder., PMID:37352688
Integration analysis of tumor metagenome and peripheral immunity data of diffuse large-B cell lymphoma., PMID:37234150
The Frequency and Function of NKG2C+CD57+ Adaptive NK Cells in Cytomagalovirus Co-Infected People Living with HIV Decline with Duration of Antiretroviral Therapy., PMID:36851537
MiR-125b and SATB1-AS1 might be shear stress-mediated therapeutic targets., PMID:36623676
The natural killer cell-associated rs9916629-C allele is a novel genetic risk factor for fatal COVID-19., PMID:36515427
Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients., PMID:36305631
Identification of immune hub genes participating in the pathogenesis and progression of Vogt-Koyanagi-Harada disease., PMID:35958546
Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions., PMID:35802353
Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia., PMID:35652109
NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme., PMID:35628668
Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas., PMID:35474089
Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome., PMID:35401541
Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection., PMID:35314764
Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients., PMID:35181606
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals., PMID:35135470
Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation., PMID:34990406
Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response., PMID:34948123
Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background., PMID:34884936
Dissection of the NKG2C NK cell response against Puumala Orthohantavirus., PMID:34871302
Long-Term Evolution of the Adaptive NKG2C+ NK Cell Response to Cytomegalovirus Infection in Kidney Transplantation: An Insight on the Diversity of Host-Pathogen Interaction., PMID:34470855
Nonameric Peptide Orchestrates Signal Transduction in the Activating HLA-E/NKG2C/CD94 Immune Complex as Revealed by All-Atom Simulations., PMID:34206395
Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point., PMID:34076484
Molecular Signatures of Natural Killer Cells in CMV-Associated Anterior Uveitis, A New Type of CMV-Induced Disease in Immunocompetent Individuals., PMID:33807229
Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood., PMID:33664730
Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions., PMID:33615729
Complete genomic characterization of a new KLRC2 allele, NKG2C*03., PMID:33608973
Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19., PMID:33500568
HCMV-controlling NKG2C+ NK cells originate from novel circulating inflammatory precursors., PMID:33493558
The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation., PMID:33123121
NK Cell Activity and CD57+/NKG2Chigh Phenotype Are Increased in Men Who Have Sex With Men at High Risk for HIV., PMID:33042136
CD56dim CD57- NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+ NKG2C+ memory-like NK cells., PMID:32930385
NKG2Cpos NK Cells Regulate the Expansion of Cytomegalovirus-Specific CD8 T Cells., PMID:32284334