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Anti-HHV-5/HCMV gH/UL75 Antibody (2-4#)

Catalog #:   RVV05101 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1
Applications: ELISA, FCM, IF, WB
Expression system: Mammalian Cells
Overview

Catalog No.

RVV05101

Expression system

Mammalian Cells

Species reactivity

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

gH, Envelope glycoprotein H

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P12824

Applications

ELISA, FCM, IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

2-4#

Data Image
References

Characterization of human cytomegalovirus infection dynamics in human microglia., PMID:40299764

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:40202318

Evaluating longitudinal cytomegalovirus-specific humoral immune responses and association with DNAemia risk in seropositive lung transplant recipients., PMID:40143922

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies., PMID:39829861

Human cytomegalovirus: pathogenesis, prevention, and treatment., PMID:39585514

A noncanonical glycoprotein H complex enhances cytomegalovirus entry., PMID:39416215

The Autonomous Fusion Activity of Human Cytomegalovirus Glycoprotein B Is Regulated by Its Carboxy-Terminal Domain., PMID:39339958

Evaluation of Bispecific T-Cell Engagers Targeting Murine Cytomegalovirus., PMID:38932161

A broadly neutralizing human monoclonal antibody generated from transgenic mice immunized with HCMV particles limits virus infection and proliferation., PMID:38832789

Seroconversion and seroprevalence of TORCH infections in a pregnant women cohort study, Mombasa, Kenya, 2017-2019., PMID:38305089

Relationship of human cytomegalovirus-infected endothelial cells and circulating leukocytes in the pathogenesis of disseminated human cytomegalovirus infection: A narrative review., PMID:38282408

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer., PMID:37967532

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells., PMID:37146061

Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018., PMID:37093863

Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes., PMID:36901847

Human immunoglobulins are transported to HCMV viral envelope by viral Fc gamma receptors-dependent and independent mechanisms., PMID:36726564

Neutralization Epitopes in Trimer and Pentamer Complexes Recognized by Potent Cytomegalovirus-Neutralizing Human Monoclonal Antibodies., PMID:36342276

An Attenuated Strain of Human Cytomegalovirus for the Establishment of a Subviral Particle Vaccine., PMID:36016214

Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein., PMID:36000848

Human cytomegalovirus (HCMV) long-term shedding and HCMV-specific immune response in pregnant women with primary HCMV infection., PMID:35960328

Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L., PMID:35891489

Neutralizing Antibodies to Human Cytomegalovirus Recombinant Proteins Reduce Infection in an Ex Vivo Model of Developing Human Placentas., PMID:35891239

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH., PMID:35468974

Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors., PMID:35452493

Horizontal Transmission of Cytomegalovirus in a Rhesus Model Despite High-Level, Vaccine-Elicited Neutralizing Antibody and T-Cell Responses., PMID:35413121

Structural basis for HCMV Pentamer receptor recognition and antibody neutralization., PMID:35275719

Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies., PMID:35275718

Neutralizing Antibodies Limit Cell-Associated Spread of Human Cytomegalovirus in Epithelial Cells and Fibroblasts., PMID:35215877

Characterization of M116.1p, a Murine Cytomegalovirus Protein Required for Efficient Infection of Mononuclear Phagocytes., PMID:34705561

Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha., PMID:34700375

A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary., PMID:34452332

Characterization of gH/gL/pUL128-131 pentameric complex, gH/gL/gO trimeric complex, gB and gM/gN glycoproteins in a human cytomegalovirus using automated capillary western blots., PMID:34229890

A Novel Strain-Specific Neutralizing Epitope on Glycoprotein H of Human Cytomegalovirus., PMID:34160252

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131., PMID:34132577

Detection of Genotype-Specific Antibody Responses to Glycoproteins B and H in Primary and Non-Primary Human Cytomegalovirus Infections by Peptide-Based ELISA., PMID:33802390

A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs., PMID:33729125

In Utero Human Cytomegalovirus Infection Is Associated With Increased Levels of Putatively Protective Maternal Antibodies in Nonprimary Infection: Evidence for Boosting but Not Protection., PMID:33560335

Antibody-Independent Quantification of Cytomegalovirus Virion Protein Incorporation Using HiBiT., PMID:33555589

Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus., PMID:33361306

Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease., PMID:32825429

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes., PMID:32746933

Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB., PMID:32641474

Immunization with Human Cytomegalovirus Core Fusion Machinery and Accessory Envelope Proteins Elicit Strong Synergistic Neutralizing Activities., PMID:32294946

Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells., PMID:32268919

Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells., PMID:32068527

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation., PMID:32015031

Polymorphisms in Human Cytomegalovirus Glycoprotein O (gO) Exert Epistatic Influences on Cell-Free and Cell-to-Cell Spread and Antibody Neutralization on gH Epitopes., PMID:31996433

MVA-Vectored Pentameric Complex (PC) and gB Vaccines Improve Pregnancy Outcome after Guinea Pig CMV Challenge, but Only gB Vaccine Reduces Vertical Transmission., PMID:31739399

Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally., PMID:31705022

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas., PMID:31569508

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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For research use only. Not for human or drug use.

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Anti-HHV-5/HCMV gH/UL75 Antibody (2-4#) [RVV05101]
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