Anti-ASGR1 Polyclonal Antibody

Catalog No.

PHC24401

Species reactivity

Human, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ASGR1 (Gln62-Leu291).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HL-1, ASGP-R 1, Asialoglycoprotein receptor 1, CLEC4H1, ASGR1, C-type lectin domain family 4 member H1, ASGPR 1, Hepatic lectin H1

Purification

Purified by antigen affinity column.

Accession

P07306

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D., PMID:39791910

Detection of γ-OHPdG in Circulating Tumor Cells of Patients With Hepatocellular Carcinoma as a Potential Prognostic Biomarker of Recurrence., PMID:39280920

Rapid depletion of "catch-and-release" anti-ASGR1 antibody in vivo., PMID:39051531

Targeted protein degradation systems to enhance Wnt signaling., PMID:38847394

The use of human iPSC-derived alveolar organoids to explore SARS-CoV-2 variant infections and host responses., PMID:38572923

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes., PMID:38355848

Analysis of SARS-CoV-2 Variant-Specific Serum Antibody Post-Vaccination Utilizing Immortalized Human Hepatocyte-Like Cells (HLC) to Assess Development of Immunity., PMID:38078048

ACE2-Independent Alternative Receptors for SARS-CoV-2., PMID:36423144

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion., PMID:35922515

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2., PMID:34837059

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2., PMID:34048708

Binding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein Receptor on Human Primary Hepatocytes and Immortalized Hepatocyte-Like Cells by Confocal Analysis., PMID:33883951

Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis., PMID:31497744

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance., PMID:29282218

The role of sialic acids in the immune recognition of xenografts., PMID:29057592

Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2., PMID:27155063

Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers., PMID:26906939

Porcine extrahepatic vascular endothelial asialoglycoprotein receptor 1 mediates xenogeneic platelet phagocytosis in vitro and in human-to-pig ex vivo xenoperfusion., PMID:25675194

ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro., PMID:21848542

A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes., PMID:20886072

[Preparation and identification of polyclonal antibody against protein H1b: the variant of major subunit of human ASGPR]., PMID:19811742

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