Catalog No.
VHD18102
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3
Concentration
2.32 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P16473
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
100 mM Pro-Ac, 20 mM Arg, pH 5.0
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
5C9
Monoclonal Antibodies to Thyrotropin Receptor With Thyroid-Stimulating Activity Activate the NF-κB Pathway to Induce Chemokine Expression., PMID:40500868
TSH Receptor Antibody Test Utilization Patterns from a National Reference Laboratory: TRAb, TSI, or Both?, PMID:40482060
Preclinical ImmunoPET Imaging of Thyroid-Stimulating Hormone Receptor Expression in Thyroid Cancer using [64Cu]Cu-NOTA-TSHR-Ab., PMID:40403201
Marked Increase in Thyrotropin Receptor Antibodies With the Development of Pretibial Myxedema After Total Thyroidectomy., PMID:40384886
Molecular pathway and mechanism responsible for the progress of thyroid-associated orbitopathy., PMID:40381066
Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management., PMID:40324443
Follicular helper T cells in Graves' disease: pathogenic mechanisms and therapeutic implications., PMID:40322944
Thyroid-related orbitopathy: clinical overview, novel medical treatments and the role of orbital surgery., PMID:40317422
Human Papillomavirus and Thyroid Eye Disease., PMID:40272832
Bacteroides fragilis and propionate synergize with low-dose methimazole to treat Graves' disease., PMID:40265938
Chimeric autoantibody receptor T cells specifically eliminate Graves' Disease autoreactive B cells., PMID:40264771
Antibodies against the receptor for insulin-like growth factor 1 (IGF-1RAb), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) in the serum of patients with Graves' and Basedow's disease with and without orbitopathy., PMID:40071798
Inflammatory and tolerogenic dendritic cells and T lymphocytes in Graves' thyroidal and orbital disease., PMID:40024060
RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs., PMID:39992626
Thyroid dermopathy and thyroid eye disease associated with hypofunctional autoimmune thyroid disease with high TSI/anti-TSHR antibodies improved with teprotumumab., PMID:39950657
Controversies Surrounding IGF-I Receptor Involvement in Thyroid-Associated Ophthalmopathy., PMID:39909461
Development of animal models to study aggressive thyroid cancers., PMID:39874138
Thyroid-Targeted Nano-Bombs Empower HIFU for Graves' Disease., PMID:39840533
The role of autophagy in Graves disease: knowns and unknowns., PMID:39834383
Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor., PMID:39821041
Establishment of Time-Resolved Fluorescence Immunoassay for Thyrotropin Receptor Antibodies and Clinical Application., PMID:39776097
Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders., PMID:39754930
Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts., PMID:39747159
Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells., PMID:39723207
Mutation spectra and genotype‑phenotype analysis of congenital hypothyroidism in a neonatal population., PMID:39720292
Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in the diagnosis and management of Graves' disease., PMID:39669491
A novel bioassay for thyroid-blocking immunoglobulins., PMID:39534254
The TSH Receptor Antibody Reactome Contributes to Retro-Orbital Inflammation., PMID:39502473
Proangiogenic effect of thyrotropin receptor stimulating antibody in human umbilical vein endothelial cells., PMID:39455509
Hypothyroidism Induced by a TSH Receptor Peptide-Implications for Thyroid Autoimmunity., PMID:39435685
STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan., PMID:39385969
Familial Nonautoimmune Hyperthyroidism Due to a TSH Receptor Gene Pathogenic Variant., PMID:39301178
Impact of ibrutinib on inflammation in a mouse model of Graves' orbitopathy., PMID:39280007
Zirconium- 89 Labeled Antibody K1-70 for PET Imaging of Thyroid-stimulating Hormone Receptor Expression in Thyroid Cancer., PMID:39174789
TSH Receptor Oligomers Associated With the TSH Receptor Antibody Reactome., PMID:39116382
TSHR-IGF-IR complex drives orbital fibroblast misbehavior in thyroid eye disease., PMID:39082947
Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes., PMID:39046281
Graves disease: latest understanding of pathogenesis and treatment options., PMID:39039206
Gut microbiome in the Graves' disease: Comparison before and after anti-thyroid drug treatment., PMID:38820506
Immune checkpoints: new insights into the pathogenesis of thyroid eye disease., PMID:38817600
Minor hyperthyroidism with normal levels of thyroid-stimulating hormone receptor antibodies: a case report., PMID:38813368
A Novel Association Between Human Papillomavirus and Thyroid Eye Disease., PMID:38746201
A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO., PMID:38650837
A Novel TSHR Gene Mutation in a Family with Non-autoimmune Hyperthyroidism., PMID:38566871
Development and basic performance verification of a rapid homogeneous bioassay for agonistic antibodies against the thyroid-stimulating hormone receptor., PMID:38447802
The full-length TSH receptor is stabilized by TSH ligand., PMID:38373379
The evaluation of retrobulbar fat tissue in Graves' orbitopathy with shear-wave ultrasound elastography., PMID:38321200
Transition from Hashimoto thyroiditis to Graves's Disease: an unpredictable change?, PMID:38117453
Refractory Thyroid Eye Disease Unresponsive to Teprotumumab: A Case Report., PMID:38111423
Comparison of two different TSH-receptor antibody assays: A clinical practice study., PMID:38107298
For research use only. Not for human or drug use.
