Anti-Human TCF7L1 Polyclonal Antibody

Catalog No.

PHK59601

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TCF7L1 (Asn351-Gly445).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

TCF7L1, TCF3, HMG box transcription factor 3, TCF-3, Transcription factor 7-like 1

Purification

Purified by antigen affinity column.

Accession

Q9HCS4

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932

Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2., PMID:27551519

Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification., PMID:23487311

Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3., PMID:23090119

TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers., PMID:20532534

Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci., PMID:19752184

The promoter of the Immunoglobulin J Chain gene receives its authentic enhancer activity through the abutting MEF2 and PU.1 sites in a DNA-looping interaction., PMID:19467243

V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia., PMID:19455608

NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors., PMID:19428458

B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins., PMID:18203819

PDX-1 can repress stimulus-induced activation of the INGAP promoter., PMID:16522740

E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1., PMID:16007194

Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases., PMID:15798207

The E protein HEB is preferentially expressed in developing muscle., PMID:15554944

Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression., PMID:15544702

Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A., PMID:15078898

Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent., PMID:15030778

Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase., PMID:14764681

E-proteins directly regulate expression of activation-induced deaminase in mature B cells., PMID:12717431

Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells., PMID:12714241

Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts., PMID:12242308

The human V-preB promoter is a target for coordinated activation by early B cell factor and E47., PMID:11994467

Mammalian Scratch participates in neuronal differentiation in P19 embryonal carcinoma cells., PMID:11687288

Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements., PMID:11171123

The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins., PMID:10989124

Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter., PMID:10779354

E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination., PMID:10562543

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A., PMID:10435576

Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter., PMID:10082523

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium., PMID:9916915

Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12., PMID:9705952

Sequence determinants of DNA binding by the hematopoietic helix-loop-helix transcription factor TAL1: importance of sequences flanking the E-box core., PMID:9699481

Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains., PMID:9671474

ETS-mediated cooperation between basic helix-loop-helix motifs of the immunoglobulin mu heavy-chain gene enhancer., PMID:9488464

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes., PMID:9252117

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation., PMID:8843199

E47 activates the Ig-heavy chain and TdT loci in non-B cells., PMID:8890174

Monoclonal antimyogenin antibodies define epitopes outside the bHLH domain where binding interferes with protein-protein and protein-DNA interactions., PMID:8900045

B cell differentiation: role of E2A and Pax5/BSAP transcription factors., PMID:7630627

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements., PMID:8001125

Regulation of G1 progression by E2A and Id helix-loop-helix proteins., PMID:7925274

Purification of E. coli-synthesized Pan proteins and development of a Pan-specific monoclonal antibody., PMID:7523277

Patterns of Pan expression and role of Pan proteins in endocrine cell type-specific complex formation., PMID:8170476

E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development., PMID:8246953

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins., PMID:8497267

Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia., PMID:1348433

The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind to neighboring sites within the c-fos serum response element., PMID:1766666

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line., PMID:1714414

Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer., PMID:1710033

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains., PMID:2112746

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Anti-Human TCF7L1 Polyclonal Antibody.pdf