Catalog No.
PHA27201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human KMT2D (Val5381-Met5536).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
KMT2D, Histone-lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, ALL1-related protein, MLL4, ALR, Lysine N-methyltransferase 2D, MLL2
Purification
Purified by antigen affinity column.
Accession
O14686
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Comparison of the mutational profile between BCL2- and BCL6-rearrangement positive follicular lymphoma., PMID:40482882
KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression., PMID:40460200
Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919
[Relapse-related candidate genes and their clinicopathological connections of diffuse large B cell lymphoma]., PMID:40159024
Mutational Landscape of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Association with Immune Checkpoint Inhibitor Outcomes., PMID:40080442
Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS)., PMID:39711167
Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study., PMID:39641321
Toripalimab Plus Chemotherapy as a First-Line Therapy for Extensive-Stage Small Cell Lung Cancer: The Phase 3 EXTENTORCH Randomized Clinical Trial., PMID:39541202
[Efficacy and safety analysis of the OR-CHOP regimen for the treatment of MCD subtype diffuse large B cell lymphoma in the real-world setting]., PMID:39414605
Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial., PMID:39278918
Molecular characterization of a rare case of high-grade B-cell lymphoma with MYC, BCL2, BCL6, and CCND1 rearrangements., PMID:38914869
Molecular Features of HHV8 Monoclonal Microlymphoma Associated with Kaposi Sarcoma and Multicentric Castleman Disease in an HIV-Negative Patient., PMID:38612584
Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement., PMID:38462571
Autoimmune cytopenia and Kabuki syndrome in paediatrics: Insights in 11 patients., PMID:38432067
Follicular Lymphoma Presenting With Symptomatic Bone Involvement: A Clinicopathologic and Molecular Analysis of 16 Cases., PMID:38290600
Diabetes mellitus in Kabuki syndrome 1 on a background of post-transplant diabetes mellitus., PMID:38290219
Feasibility of Circulating Tumor DNA Analysis in Patients with Follicular Lymphoma., PMID:38228081
The genomic and immune landscapes of gastric cancer and their correlations with HER2 amplification and PD-L1 expression., PMID:38050871
Pucotenlimab in patients with advanced mismatch repair-deficient or microsatellite instability-high solid tumors: A multicenter phase 2 study., PMID:38016482
Case report: Clinicopathological and molecular characteristics of pediatric-type follicular lymphoma., PMID:37539011
[Clinicopathologic characteristics and prognostic analysis of testicular diffuse large B-cell lymphoma]., PMID:37357002
A case of cold agglutinin syndrome associated with chronic lymphocytic leukaemia harbouring mutations in CARD11 and KMT2D., PMID:37133636
Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar., PMID:36917966
[Clinical analysis of 20 cases of small B lymphocyte proliferative disease with t (14;19) (q32;q13)]., PMID:36709153
Case report: A study on the de novo KMT2D variant of Kabuki syndrome with Goodpasture's syndrome by whole exome sequencing., PMID:36090579
A novel immune-related epigenetic signature based on the transcriptome for predicting the prognosis and therapeutic response of patients with diffuse large B-cell lymphoma., PMID:36055572
Follicular lymphoma: The long and winding road leading to your cure?, PMID:35908982
Mantle cell lymphoma in 2022-A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments., PMID:35266562
Efficacy and Safety of Sintilimab Plus Anlotinib for PD-L1-Positive Recurrent or Metastatic Cervical Cancer: A Multicenter, Single-Arm, Prospective Phase II Trial., PMID:35192397
The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells., PMID:34967008
Decreased expression of T-cell-associated immune markers predicts poor prognosis in patients with follicular lymphoma., PMID:34837284
Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation., PMID:34601504
Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation., PMID:34265801
Clinical heterogeneity of Kabuki syndrome in a cohort of Italian patients and review of the literature., PMID:34232366
Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients., PMID:34168983
There is no gene for CVID - novel monogenetic causes for primary antibody deficiency., PMID:34153571
Proposal and validation of a method to classify genetic subtypes of diffuse large B cell lymphoma., PMID:33479306
Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma., PMID:33376237
Activity of ibrutinib plus R-CHOP in diffuse large B-cell lymphoma: Response, pharmacodynamic, and biomarker analyses of a phase Ib study., PMID:33188997
Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report., PMID:32871937
A Rare Cause of Hyperinsulinemic Hypoglycemia: Kabuki Syndrome., PMID:32830475
Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency., PMID:32745555
Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma., PMID:32589730
Molecular profiling of Chinese R-CHOP treated DLBCL patients: Identifying a high-risk subgroup., PMID:32399964
Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT+ B-lymphoblastic leukemia/lymphoma., PMID:31776129
Molecular characteristics of terminal deoxynucleotidyl transferase negative precursor B-cell phenotype Burkitt leukemia with IGH-MYC rearrangement., PMID:31705772
Clinical and molecular characteristics of lymphoplasmacytic lymphoma not associated with an IgM monoclonal protein: A multicentric study of the Rete Ematologica Lombarda (REL) network., PMID:31378966
CARM1 methylates MED12 to regulate its RNA-binding ability., PMID:30456381
New concepts in follicular lymphoma biology: From BCL2 to epigenetic regulators and non-coding RNAs., PMID:30360879
Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes., PMID:30232013
For research use only. Not for human or drug use.
