Anti-Human ZFP36 Polyclonal Antibody

Catalog No.

PHD71701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZFP36 (Thr106-Gly176).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP

Purification

Purified by antigen affinity column.

Accession

P26651

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis., PMID:40328742

Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis., PMID:40234384

Copy number variation and clinical response to chemotherapy and bevacizumab in the Czech metastatic colorectal cancer patients., PMID:39174331

The RNA binding proteins ZFP36L1 and ZFP36L2 are dysregulated in airway epithelium in human and a murine model of asthma., PMID:37928904

Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models., PMID:37535204

RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease., PMID:35861833

Cisplatin resistance of NSCLC cells involves upregulation of visfatin through activation of its transcription and stabilization of mRNA., PMID:34656559

Regulated Tristetraprolin Overexpression Dampens the Development and Pathogenesis of Experimental Autoimmune Uveitis., PMID:33569048

Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice., PMID:32922402

Dynamics of peripheral T cell clones during PD-1 blockade in non-small cell lung cancer., PMID:32591861

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1., PMID:28394372

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence., PMID:27102483

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies., PMID:26831084

Sustained interleukin-1β exposure modulates multiple steps in glucocorticoid receptor signaling, promoting split-resistance to the transactivation of prominent anti-inflammatory genes by glucocorticoids., PMID:25977599

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes., PMID:22701344

A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients., PMID:21875902

Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells., PMID:21593445

Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells., PMID:19092855

Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli., PMID:18302406

Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease., PMID:17324400

Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications., PMID:15504035

[Analysis of the kinetic of expression of tristetraprolin and HuR by rheumatoid arthritis patients peripheral blood mononuclear cells stimulated with lipopolysaccharide]., PMID:15309217

Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs., PMID:15280467

Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis., PMID:15170914

Regulation and localization of endogenous human tristetraprolin., PMID:12823857

Analysis of the function, expression, and subcellular distribution of human tristetraprolin., PMID:12115244

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling., PMID:11796723

HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities., PMID:11602610

Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome., PMID:11588035

Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction., PMID:9276715

A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency., PMID:8630730

Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway., PMID:8534915

Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction., PMID:8063739

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