Anti-Human PGRMC1 Polyclonal Antibody

Catalog No.

PHA07501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PGRMC1 (Pro75-Asp195).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

PGRMC, mPR, IZA, Membrane-associated progesterone receptor component 1, HPR6.6, Dap1, PGRMC1

Purification

Purified by antigen affinity column.

Accession

O00264

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Increase in FoxP3, CD56 immune cells and decrease in glands PGRMC1 expression in the endometrium are associated with recurrent miscarriages., PMID:31891895

Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surface., PMID:30679694

Progesterone Receptor Membrane Component 1 suppresses the p53 and Wnt/β-catenin pathways to promote human pluripotent stem cell self-renewal., PMID:29445107

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis., PMID:26657863

Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study., PMID:26485238

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice., PMID:25796326

PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma., PMID:25596698

Pathways driving the endocytosis of mutant and wild-type EGFR in cancer., PMID:25594057

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity., PMID:25390692

Progesterone receptor membrane component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized rat granulosa cells., PMID:25253729

Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells., PMID:22719051

Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1., PMID:22418433

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization., PMID:21455559

Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation., PMID:21228216

A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis., PMID:21148105

Changes in PGRMC1, a potential progesterone receptor, in human myometrium during pregnancy and labour at term and preterm., PMID:21131300

Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development., PMID:20739377

Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis., PMID:19208546

Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1., PMID:18922159

Regulation of ovarian cancer cell viability and sensitivity to cisplatin by progesterone receptor membrane component-1., PMID:18319313

Expression of progesterone and oestrogen receptors by early intrauterine equine conceptuses., PMID:18037481

Progesterone regulation of human granulosa/luteal cell viability by an RU486-independent mechanism., PMID:16984987

Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action., PMID:16513825

Molecular identification of adrenal inner zone antigen as a heme-binding protein., PMID:16279947

Expression and function of PAIRBP1 within gonadotropin-primed immature rat ovaries: PAIRBP1 regulation of granulosa and luteal cell viability., PMID:15814896

Systematic screening and identification of antigens recognized by monoclonal antibodies raised against the developing lateral olfactory tract., PMID:15514993

Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis., PMID:15026187

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