Anti-ABCC8 Polyclonal Antibody

Catalog No.

PHG20501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ABCC8 (Val679-Thr929).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

SUR, SUR1, HRINS, ABCC8, ATP-binding cassette sub-family C member 8, Sulfonylurea receptor 1

Purification

Purified by antigen affinity column.

Accession

Q09428

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Genotype, Phenotype, and Clinical Characteristics of Maturity-onset Diabetes of the Young (MODY): Predominance of GCK-MODY., PMID:40338033

Permanent Neonatal Diabetes with High Insulin Requirements Due to a New Variant in the INS Gene., PMID:39710984

Molecular and clinical profiles of pediatric monogenic diabetes subtypes: comprehensive genetic analysis of 138 patients., PMID:39504571

VARIATIONS IN MONOGENIC DIABETES AND DIABETES SUSCEPTIBILITY GENES IN PEDIATRIC CASES: SINGLE CENTER EXPERIENCE., PMID:38933241

Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship., PMID:38665000

Structural bioinformatics studies of six human ABC transporters and their AlphaFold2-predicted water-soluble QTY variants., PMID:38577032

Screening of Mutations in Maturity-onset Diabetes of the Young-related Genes and RFX6 in Children with Autoantibody-negative Type 1 Diabetes Mellitus., PMID:38054414

High Frequency of Recessive WFS1 Mutations Among Indian Children With Islet Antibody-negative Type 1 Diabetes., PMID:37931151

ABCC8-Related Monogenic Diabetes Presenting Like Type 1 Diabetes in an Adolescent., PMID:37520758

Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism., PMID:37358194

Thyrotoxic periodic paralysis in a Caucasian man without identifiable genetic predisposition: a case report., PMID:37122018

Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran., PMID:36100423

Glibenclamide attenuates brain edema associated with microglia activation after intracerebral hemorrhage., PMID:35963712

The coexistence of autoimmune diabetes and maturity-onset diabetes of the young (MODY): a case series., PMID:35894830

ABCC8-related maturity-onset diabetes of the young: Clinical features and genetic analysis of one case., PMID:35757975

Hypertriglyceridemia with acute pancreatitis in a 14-year-old girl with diabetic ketoacidosis., PMID:34015902

Systematic Genetic Study of Youth With Diabetes in a Single Country Reveals the Prevalence of Diabetes Subtypes, Novel Candidate Genes, and Response to Precision Therapy., PMID:32086287

SUR1-TRPM4 channels, not KATP, mediate brain swelling following cerebral ischemia., PMID:31899311

Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry., PMID:27913849

ABCC8-Related Maturity-Onset Diabetes of the Young (MODY12): Clinical Features and Treatment Perspective., PMID:27538677

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population., PMID:27167055

Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes., PMID:24569881

A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child., PMID:23843578

Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry., PMID:23624530

Enhancement of liver regeneration by adenosine triphosphate-sensitive K⁺ channel opener (diazoxide) after partial hepatectomy., PMID:22466787

KATP channels in mesenchymal stromal stem cells: strong up-regulation of Kir6.2 subunits upon osteogenic differentiation., PMID:21820692

Different localization of ATP sensitive K+ channel subunits in rat testis., PMID:21328565

Roles of sulfonylurea receptor 1 and multidrug resistance protein 1 in modulating insulin secretion in human insulinoma., PMID:21269941

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies., PMID:20863361

Human oocytes express ATP-sensitive K(+) channels., PMID:20847183

Endoplasmic reticulum accumulation of Kir6.2 without activation of ER stress response in islet cells from adult Sur1 knockout mice., PMID:20383647

KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy., PMID:20102598

ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury., PMID:19422886

Mutations in the ABCC8 gene can cause autoantibody-negative insulin-dependent diabetes., PMID:19342262

Mutations in the ABCC8 (SUR1 subunit of the K(ATP) channel) gene are associated with a variable clinical phenotype., PMID:19021632

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1., PMID:18974387

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence., PMID:18390792

Glucose intolerance and diabetes are observed in the long-term follow-up of nonpancreatectomized patients with persistent hyperinsulinemic hypoglycemia of infancy due to mutations in the ABCC8 gene., PMID:18339976

Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium., PMID:18323694

Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas., PMID:17593344

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development., PMID:17380317

Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria., PMID:16051627

Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts., PMID:16050978

Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels., PMID:15811927

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets., PMID:15220194

Heart mitochondria contain functional ATP-dependent K+ channels., PMID:14596790

Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain., PMID:13679426

The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas., PMID:12606519

Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death., PMID:12603842

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