Catalog No.
PHK17201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CLEC2D/OCIL/LLT1 (Arg60-Val191).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CLAX, C-type lectin domain family 2 member D, Osteoclast inhibitory lectin, CLEC2D, Lectin-like transcript 1, Lectin-like NK cell receptor, OCIL, LLT-1, LLT1
Purification
Purified by antigen affinity column.
Accession
Q9UHP7
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Associations of genetic polymorphisms with clinical response to tocilizumab in Chinese rheumatoid arthritis patients., PMID:39718059
Targeting LLT1 as a potential immunotherapy option for cancer patients non-responsive to existing checkpoint therapies in multiple solid tumors., PMID:39511540
Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies., PMID:38153903
C-TYPE LECTIN-2D RECEPTOR CONTRIBUTES TO HISTONE-INDUCED VASCULAR BARRIER DYSFUNCTION DURING BURN INJURY., PMID:37878490
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis., PMID:33592174
Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 (CLEC2D) in Cancer., PMID:32630303
Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals., PMID:32449811
Lectin-like transcript 1 as a natural killer cell-mediated immunotherapeutic target for triple negative breast cancer and prostate cancer., PMID:34322598
Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells., PMID:30034942
Vaccinia virus Western Reserve induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D., PMID:27862195
Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction., PMID:27626681
Genetic and clinical biomarkers of tocilizumab response in patients with rheumatoid arthritis., PMID:27339827
Different genetic associations of the IgE production among fetus, infancy and childhood., PMID:23936416
LLT1-mediated activation of IFN-gamma production in human natural killer cells involves ERK signalling pathway., PMID:20415786
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells., PMID:18453569
Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein., PMID:16842926
The LLT1 receptor induces IFN-gamma production by human natural killer cells., PMID:15104121
For research use only. Not for human or drug use.
