Catalog No.
YHK65501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu125-Leu469
Predicted molecular weight
40.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y512
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAM50, Transformation-related gene 3 protein, Sorting and assembly machinery component 50 homolog, SAMM50, TRG-3
A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework., PMID:40434633
Mitochondria-related genes as prognostic signature of endometrial cancer and the effect of MACC1 on tumor cells., PMID:40354443
SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics., PMID:40052924
Genetic predisposition of metabolic dysfunction-associated steatotic liver disease: a population-based genome-wide association study., PMID:39755997
PNPLA3 and SAMM50 variants are associated with lean nonalcoholic fatty liver disease in Asian population., PMID:39638042
Salmonella infection impacts host proteome thermal stability., PMID:39128247
Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes., PMID:38770789
Mitochondrial outer membrane protein Samm50 protects against hypoxia-induced cardiac injury by interacting with Shmt2., PMID:38723737
PARVB and HSD17B13 variants are associated with nonalcoholic fatty liver disease in children., PMID:38418429
Identification of candidate mitochondrial inheritance determinants using the mammalian cell-free system., PMID:37470242
Endosomal-dependent mitophagy coordinates mitochondrial nucleoid and mtDNA elimination., PMID:36691806
Genetic Variation of SAMM50 Is Not an Independent Risk Factor for Alcoholic Hepatocellular Carcinoma in Caucasian Patients., PMID:36499681
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA., PMID:36344526
Update on Non-Alcoholic Fatty Liver Disease-Associated Single Nucleotide Polymorphisms and Their Involvement in Liver Steatosis, Inflammation, and Fibrosis: A Narrative Review., PMID:36000237
SAMM50 Regulates Thermogenesis of Beige Adipocytes Differentiated from Human Adipose-Derived Stem Cells by Balancing Mitochondrial Dynamics., PMID:35743205
CARD19 Interacts with Mitochondrial Contact Site and Cristae Organizing System Constituent Proteins and Regulates Cristae Morphology., PMID:35406738
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle., PMID:35368021
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury., PMID:35313046
Mitochondria shed their outer membrane in response to infection-induced stress., PMID:35025629
Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes., PMID:34631840
Effects of PNPLA3, TM6SF2 and SAMM50 on the development and severity of non-alcoholic fatty liver disease in children., PMID:34490745
SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy., PMID:34275433
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components., PMID:34037656
The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms., PMID:33728819
Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians., PMID:33444683
Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy., PMID:33173052
SAM50, a side door to the mitochondria: The case of cytotoxic proteases., PMID:32919042
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2., PMID:31617661
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network., PMID:31311600
Mitochondrial cristae narrowing upon higher 2-oxoglutarate load., PMID:31247171
Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact., PMID:31097788
Genetics of nonalcoholic fatty liver disease in Asian populations., PMID:30945694
Identification and characterization of protein N-myristoylation occurring on four human mitochondrial proteins, SAMM50, TOMM40, MIC19, and MIC25., PMID:30427857
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology., PMID:29874585
Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population., PMID:29307798
Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population., PMID:29271184
Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50., PMID:28808085
Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis., PMID:28338658
Mendelian randomization estimates of alanine aminotransferase with cardiovascular disease: Guangzhou Biobank Cohort study., PMID:28007909
The PNPLA3 Genetic Variant rs738409 Influences the Progression to Cirrhosis in HIV/Hepatitis C Virus Coinfected Patients., PMID:27973562
SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells., PMID:27059175
Depletion of SAM50 Specifically Targets BCR-ABL-Expressing Leukemic Stem and Progenitor Cells by Interfering with Mitochondrial Functions., PMID:26855047
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure., PMID:26530328
Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex., PMID:26477565
Impact of genetic polymorphisms associated with nonalcoholic fatty liver disease on HIV-infected individuals., PMID:26352879
Identification of Human N-Myristoylated Proteins from Human Complementary DNA Resources by Cell-Free and Cellular Metabolic Labeling Analyses., PMID:26308446
Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2., PMID:26016997
QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology., PMID:25997101
Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits., PMID:25781180
Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease., PMID:25776890
For research use only. Not for human or drug use.
