Catalog No.
YXX09401
Description
Cleaves terminal sialic-acid residues that are α2,3-, α2,6-, or α2,8-linked to Gal, GlcNAc, GalNAc, AcNeu, GlcNeu, oligosaccharides, glycolipids, or glycoproteins. Relative rate of cleavage is α2,3 >α2,8 = α2,6, determined on bonds in tri- and tetrasaccharides.
Expression system
E. coli
Species
Clostridium perfringens
Protein length
Neuraminidase (Sialidase) is cloned from Clostridium perfringens and expressed in E. coli.
Predicted molecular weight
44.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Applications
Neuraminidase (Sialidase) has been used to desialylate transferrin in order to study its isoforms in human serum.
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 2 to 8 °C for one week .Store at -20 to -80 °C for twelve months from the date of receipt.
Alternative Names
Sialidase, 3.2.1.18, Neuraminidase; nanH
Combination of recombinant neuraminidase with cHA-based inactivated split vaccines improves the breadth of cross-reactivity and protection against influenza viruses in mice., PMID:40513214
Epidemiological characteristics of human parainfluenza virus infections and phylogenetic analysis of human parainfluenza virus type 3 isolated from children with respiratory tract infections from 2020 to 2022 in Zhejiang, China., PMID:40512414
N-Glycosylation as a Key Requirement for the Positive Interaction of Integrin and uPAR in Glioblastoma., PMID:40508119
Correction for Lv et al., "Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model"., PMID:40503918
Morphology-dependent entry kinetics and spread of influenza A virus., PMID:40490555
The role of sialic acid and macromolecular depletion interactions in red blood cell adhesion: Insights from interference reflection microscopy., PMID:40483864
Influenza neuraminidase active site proximity assay for rapid profiling of inhibitory antibodies and antigenic drift., PMID:40483362
[Efficacy of neuraminidase inhibitors against influenza]., PMID:40478493
Data-driven discovery of chemical signatures for developing new inhibitors against human influenza viruses., PMID:40474202
Development of molnupiravir and peramivir loaded liposome formulations for combined antiviral therapy., PMID:40470763
Type I Sialidosis in a Chinese family: a case report and literature review., PMID:40468413
A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution., PMID:40464562
No indication of highly pathogenic avian influenza infections in Dutch cows., PMID:40458141
Hydroethanolic extract of Schinus terebinthifolia as a promising source of anti-influenza agents: Phytochemical profiling, cheminformatics, molecular docking and dynamics simulations., PMID:40455719
Computational prediction of cyclotides from Viola odorata as potential inhibitors against the neuraminidase of Streptococcus pneumoniae., PMID:40439881
Phylogenetic Analysis and Spread of HPAI H5N1 in Middle Eastern Countries Based on Hemagglutinin and Neuraminidase Gene Sequences., PMID:40431745
A Review of Cross-Species Transmission Mechanisms of Influenza Viruses., PMID:40431540
A neuraminidase-based electrochemical biosensor for high-throughput screening of antiviral compounds in traditional Chinese medicine., PMID:40425963
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α., PMID:40411250
Guided design for the development of an evolution-proof influenza vaccine., PMID:40398325
Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal., PMID:40397678
Fabrication of aramid-based antimicrobial polypropylene composite membranes functionalized with thiazolidine-based nanoparticles., PMID:40391368
Correction to: Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin., PMID:40391285
Guillain-Barré Syndrome Following Moderna Spikevax Messenger RNA COVID-19 Vaccine: A Case Analysis., PMID:40386749
A Comprehensive Review of Antimicrobial Drugs: Mechanisms of Action and Specific Targets in Microorganisms., PMID:40384354
Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza during 2023., PMID:40383519
A novel chimpanzee adenovirus vector vaccine for protection against infectious bronchitis and Newcastle disease in chickens., PMID:40375108
Which Enhanced Influenza Vaccine Has the Greatest Immunogenicity in Long-Term Care Residents: The Adjuvanted or the High-Dose Formulation?, PMID:40373825
[Not Available]., PMID:40369994
Genetic diversity of A(H5N1) avian influenza viruses isolated from birds and seals in Russia in 2023., PMID:40369040
Role of Respiratory Viruses in Severe Acute Respiratory Failure., PMID:40364206
A Tissue Section-Based Mid-Infrared Spectroscopical Analysis of Salivary Gland Tumors Based on Enzymatic Deglycosylation., PMID:40361471
Molecular Evolution of Influenza A Viruses From Mauritius, 2017-2019., PMID:40360235
Binding antibody titers against the hemagglutinin and neuraminidase correlate with protection against medically attended influenza A and B disease., PMID:40358209
Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase., PMID:40348878
Identification & genetic & virological characterisation of a human case of avian influenza A (H9N2) virus from Eastern India., PMID:40347502
Influenza virus: Genomic insights, evolution, and its clinical presentation., PMID:40345348
Intranasal vaccination with multi-neuraminidase and M2e virus-like particle vaccine results in greater mucosal immunity and protection against influenza than intramuscular injection., PMID:40339180
Synthetic Neuraminidase Vaccine Induces Cross-Species and Multi-Subtype Protection., PMID:40333263
Detection and characterization of novel respiratory viruses among native ducks (Anas luzonica) in Central Luzon, the Philippines., PMID:40331041
Impact of the polymerase acidic protein E199K substitution in influenza A viruses on baloxavir susceptibility., PMID:40324596
Occurrence and removal of pharmaceuticals in hospital wastewater and the contribution to wastewater treatment plants., PMID:40311897
Seroprevalence of anti-influenza antibodies in humans and characterization of seasonal influenza viruses isolated in Russia during the 2023-2024 flu season., PMID:40307541
A Review of Pediatric Influenza., PMID:40305632
Emergence of HPAI H5N6 Clade 2.3.4.4b in Wild Birds: A Case Study From South Korea, 2023., PMID:40303050
Reverse zoonosis of the 2022-2023 human seasonal H3N2 detected in swine., PMID:40295797
Chimeric virus-like particles of nodavirus displaying M2e of human and avian influenza A viruses as a potential dual-use vaccine: Inducing a broader immune response and protecting mice against viral infections., PMID:40286563
A fluorometric and naked eye readable neuraminidase probe for influenza virus detection., PMID:40280010
Multivalent H3 COBRA-based influenza vaccine elicits enhanced immune response in a pre-immune elderly ferret model., PMID:40267617
Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza., PMID:40267424
For research use only. Not for human or drug use.
