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Research Grade Rovelizumab (DHC13102)

Host species:Humanized
Isotype:IgG4-nd
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHC13102

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-nd

Clonality

Monoclonal

Target

Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2, CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, ITGAM, CD11b, CD11 antigen-like family member B, Integrin alpha-M, CR3A, CD11B, Neutrophil adherence receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05107 & (P20701 + P11215)

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Bispecific, Hu23F2G, 23F2G, CAS: 339086-79-2

Clone ID

Rovelizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Rovelizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Rovelizumab (ICOS Corp), PMID: 16100700

Acute anti-inflammatory approaches to ischemic stroke, PMID: 20955437

Hu23F2G. 23F2G, LeukArrest, PMID: 10565976

Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke, PMID: 12365824

Prevention of vasospasm by anti-CD11/CD18 monoclonal antibody therapy following subarachnoid hemorrhage in rabbits, PMID: 15255256

The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study, PMID: 12383565

An anti-CD11/CD18 monoclonal antibody in patients with acute myocardial infarction having percutaneous transluminal coronary angioplasty (the FESTIVAL study), PMID: 11524054

Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia, PMID: 9784282

Vascular closure devices and the risk of vascular complications after percutaneous coronary intervention in patients receiving glycoprotein IIb-IIIa inhibitors, PMID: 11524056

Datasheet

Document Download

Research Grade Rovelizumab.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Rovelizumab [DHC13102]
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