Catalog No.
DHD41002
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P20701
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
afolimomab, anti-LFA1, CAS: 159445-64-4
Clone ID
Odulimomab
Protective effect of an anti-LFA 1 monoclonal antibody (odulimomab) on renal damage due to ischemia and kidney autotransplantation, PMID: 10715487
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection, PMID: 33251934
A primate model of renal ischemia-reperfusion injury for preclinical evaluation of the antileukocyte function associated antigen 1 monoclonal antibody odulimonab, PMID: 11586260
What's in the pipeline? New immunosuppressive drugs in transplantation, PMID: 12482141
IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade, PMID: 30374350
Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients, PMID: 23240587
Anti-LFA-1 antibodies enhance metastasis of ocular lymphoma to the brain and contralateral eye, PMID: 22865235
Protection of porcine islet xenografts in mice using sertoli cells and monoclonal antibodies, PMID: 22037619
Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft, PMID: 26102611
Suppression of atopic-like dermatitis by treatment with antibody to lymphocyte function-associated antigen-1 in NC/Nga mouse, PMID: 15507227
Inhibition of recall responses through complementary therapies targeting CD8+ T-cell- and alloantibody-dependent allocytotoxicity in sensitized transplant recipients, PMID: 23069206
LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming, PMID: 21466654
Blocking ICAM-1 (CD54) and LFA-1 (CD11a) inhibits experimental allergic conjunctivitis, PMID: 10527686
Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes, PMID: 2423600
Anti-LFA-1 antibody postpones T-cell receptor triggering while preserving generation of regulatory T cells in T-cell receptor anti-HY transgenic mice, PMID: 16861951
Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation, PMID: 24038578
Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1, PMID: 9103242
Differential promotion of hematopoietic chimerism and inhibition of alloreactive T cell proliferation by combinations of anti-CD40Ligand, anti-LFA-1, everolimus, and deoxyspergualin, PMID: 18675355
Contrasting effects of anti-adhesion molecule therapy in experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis, PMID: 10408964
Lymphocyte function-associated antigen (LFA-1) is involved in B cell activation, PMID: 2422269
Prolonged islet allograft survival by adenovirus-mediated transfer of sICAM-1/Ig immunoadhesin gene, PMID: 12215265
Effects of humanized monoclonal antibody to rhesus CD11a in rhesus monkey cardiac allograft recipients, PMID: 10852588
HIV-induced syncytium formation requires the formation of conjugates between virus-infected and uninfected T-cells in vitro, PMID: 1687645
Lymphocyte function-associated antigen-1 is required for maximum elicitation of allergic contact dermatitis, PMID: 7918009
Combined costimulation blockade prevents rejection of allogeneic islets in mice, PMID: 16970681
Mechanisms of tumor cell capture by activated macrophages: evidence for involvement of lymphocyte function-associated (LFA)-1 antigen, PMID: 2422281
Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells, PMID: 1672652
Small molecule LFA-1 antagonists compete with an anti-LFA-1 monoclonal antibody for binding to the CD11a I domain: development of a flow-cytometry-based receptor occupancy assay, PMID: 12799043
Phorbol ester treatment enhances binding of mononuclear leukocytes to autologous and allogeneic gamma-interferon-treated keratinocytes, which are blocked by anti-LFA-1 monoclonal antibody, PMID: 2452208
A randomized multicenter trial comparing leukocyte function-associated antigen-1 monoclonal antibody with rabbit antithymocyte globulin as induction treatment in first kidney transplantations, PMID: 8970608
[Role of calcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice], PMID: 10615777
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice, PMID: 12134096
Cell receptors for the mammalian reovirus. IV. Reovirus-specific cytolytic T cell lines that have idiotypic receptors recognize anti-idiotypic B cell hybridomas, PMID: 2579153
The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex, PMID: 1602816
Mechanisms of binding of Brucella abortus to mononuclear phagocytes from cows naturally resistant or susceptible to brucellosis, PMID: 7941309
Enhancement of lymphokine-activated killer cell activity by fibronectin, PMID: 9087384
Monoclonal cytotoxic T lymphocyte hybridomas capable of specific killing activity, antigenic responsiveness, and inducible interleukin secretion, PMID: 6190926
Rheumatoid synovial fibroblasts are stimulated by the cellular adhesion to T cells through lymphocyte function associated antigen-1/intercellular adhesion molecule-1, PMID: 9058649
Effect of anti-LFA-1 monoclonal antibody on rat small bowel allograft survival and circulating leukocyte populations, PMID: 10834613
Effects of monoclonal antibodies directed at cell surface molecules on murine experimental autoimmune uveoretinitis, PMID: 10502060
Combination of anti-ICAM-1 and anti-LFA-1 monoclonal antibody therapy prolongs allograft survival in rat hind-limb transplants, PMID: 11598825
Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice, PMID: 10861270
Beta 2-integrin, LFA-1-mediated p125FAK activation, PMID: 10863474
Monotherapy with anti-LFA-1 monoclonal antibody promotes long-term survival of rat islet xenografts, PMID: 18819248
Potent and effective prolongation by anti-LFA-1 monoclonal antibody monotherapy of non-primarily vascularized heart allograft survival in mice without T cell depletion, PMID: 8094583
Potent ability of anti-LFA-1 monoclonal antibody to prolong allograft survival, PMID: 6427995
Antigen presentation by murine splenic, but not hepatic, antigen-presenting cells to induce IL-2/IL-4 production from immune T cells is regulated by interactions between LFA-1/ICAM-1, PMID: 1362565
Ligation of CD3 triggers transmembrane proximity between LFA-1 and cortical microfilaments in a cytotoxic T cell clone derived from tumor infiltrating lymphocytes: a quantitative resonance energy transfer microscopy study, PMID: 8138585
Lymphocyte function-associated antigens one (LFA-1) on B and on T lymphocytes bind a monoclonal antibody with different affinities, PMID: 3882242
In vivo effects of monoclonal antibody against ICAM-1 and LFA-1 on antigen-induced nasal symptoms and eosinophilia in sensitized rats, PMID: 8859224
For research use only. Not for human or drug use.
