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Research Grade Itolizumab

Catalog #:   DHD87601 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD87601

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

TP120, CD6, T12, T-cell differentiation antigen CD6

Concentration

5.85 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P30203

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

T1h, CAS: 1116433-11-4

Clone ID

Itolizumab

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
  • SDS-PAGE
    SDS PAGE for Itolizumab
  • Bioactivity
    Detects CD6 in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab., PMID:28672038

A Real-World Study to Assess the Effectiveness of Itolizumab in Patients with Chronic Plaque Psoriasis., PMID:28761839

Itolizumab in Psoriasis., PMID:28794555

Itolizumab in the Management of Psoriasis with Metabolic Syndrome., PMID:28893023

The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial., PMID:28963724

Itolizumab - A New Biologic for Management of Psoriasis and Psoriatic Arthritis., PMID:29033818

Commentary: CD6 As a Potential Target for Treating Multiple Sclerosis., PMID:29033937

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis., PMID:29271481

Correction: T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab., PMID:29381749

Clinical and experimental evidence for targeting CD6 in immune-based disorders., PMID:29526637

CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action., PMID:29772075

Comparative efficacy and safety of thirteen biologic therapies for patients with moderate or severe psoriasis: A network meta-analysis., PMID:30922656

New Targeted Therapies for Uncontrolled Asthma., PMID:31076057

Spotlight on itolizumab in the treatment of psoriasis - current perspectives from India., PMID:31119094

A retrospective case series of 12 patients with chronic reactive arthritis with emphasis on treatment outcome with biologics., PMID:31293276

Anti-CD6 mAbs for the treatment of psoriasis., PMID:32466689

Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications., PMID:32700604

Are We Jumping the Gun with Itolizumab in India? A Situational Analysis from the Pre-COVID Era., PMID:33015549

Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour?, PMID:33048300

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review., PMID:33068263

Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19., PMID:33105142

Scientists criticize use of unproven COVID drugs in India., PMID:33169025

An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients., PMID:33292350

Treatment of COVID-19 patients with the anti-CD6 antibody itolizumab., PMID:33304584

Possible treatment and strategies for COVID-19: review and assessment., PMID:33336780

Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis., PMID:33378357

Pulmonary Thrombosis in COVID-19 Treated by Thrombolysis: A Small Case Series Using Streptokinase., PMID:33378782

An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases., PMID:33397150

Antibodies to watch in 2021., PMID:33459118

Itolizumab Treatment for Cytokine Release Syndrome in Moderate to Severe Acute Respiratory Distress Syndrome Due to COVID-19: Clinical Outcomes, A Retrospective Study., PMID:33527804

A two-arm, randomized, controlled, multi-centric, open-label phase-2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID-19., PMID:33835886

Monoclonal Antibodies vs COVID-19: Eduardo Ojito-Magaz MS General Director, Molecular Immunology Center., PMID:33974610

Off-label Use of Itolizumab in Patients with COVID-19 ARDS: Our Clinical Experience in a Dedicated COVID Center., PMID:34045817

Second-degree Heart Block Caused by Itolizumab-induced Infusion Reaction in COVID-19., PMID:34045820

Potential effects of itolizumab treatment on plasma interleukin-6 levels in patients with severe COVID-19., PMID:34169913

Cytokine Storm and Immunomodulation in COVID-19., PMID:34866828

Pharmacological treatment of COVID-19: an opinion paper., PMID:34894208

An Exploratory Study of Itolizumab on the Preservation of Beta Cell Function in Adults with Recent-Onset Type 1 Diabetes., PMID:35407396

Phenotypic and functional characterization of the CD6-ALCAM T-cell co-stimulatory pathway after allogeneic cell transplantation., PMID:35484649

COVID-19 mortality and its predictors in the elderly: A systematic review., PMID:35620541

Severe bronchospasm following itolizumab infusion in a COVID-19 patient., PMID:36060191

Adverse drug reactions of itolizumab in COVID-19 patient: A case report., PMID:36537408

Anti CD-6 Monoclonal Antibodies in the Management of Generalised Pustular Psoriasis., PMID:36865872

REcovery and SURvival of patients with moderate to severe acute REspiratory distress syndrome (ARDS) due to COVID-19: a multicenter, single-arm, Phase IV itolizumab Trial: RESURRECT., PMID:37073744

Role of Itolizumab in the Treatment of COVID-19 Patients, Admitted to ICU at a Tertiary Care Hospital., PMID:37355865

Comparative evaluation of tocilizumab and itolizumab for treatment of severe COVID-19 in India: a retrospective cohort study., PMID:38556909

Long-term therapy with itolizumab is safe and effective for patients with moderate to severe psoriasis: Results from an expanded-access program., PMID:38759368

Contemporary Updates in the Prevention and Treatment of Graft-Versus-Host Disease., PMID:39520614

Corrigendum to: Comparative evaluation of tocilizumab and itolizumab for treatment of severe COVID-19 in India: a retrospective cohort study., PMID:39622603

Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines., PMID:40391211

Pulmonary Thrombosis in COVID-19 Treated by Thrombolysis: A Small Case Series Using Streptokinase, PMID: 33378782

An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases, PMID: 33397150

Which are the antibodies to watch in 2013?, PMID: 23254906

Biologics use in Indian psoriasis patients, PMID: 27990383

CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action, PMID: 29772075

Antibodies to watch in 2013: Mid-year update, PMID: 23727858

Clinical and experimental evidence for targeting CD6 in immune-based disorders, PMID: 29526637

Scientists criticize use of unproven COVID drugs in India, PMID: 33169025

A two-arm, randomized, controlled, multi-centric, open-label phase-2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID-19, PMID: 33835886

Long-term efficacy and safety of itolizumab in patients with moderate-to-severe chronic plaque psoriasis: A double-blind, randomized-withdrawal, placebo-controlled study, PMID: 26183983

Second-degree Heart Block Caused by Itolizumab-induced Infusion Reaction in COVID-19, PMID: 34045820

Potential effects of itolizumab treatment on plasma interleukin-6 levels in patients with severe COVID-19, PMID: 34169913

Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab, PMID: 24594862

Anti-CD6 mAbs for the treatment of psoriasis, PMID: 32466689

Erratum: Itolizumab - a humanized anti-CD6 monoclonal antibody with better side effects profile for the treatment of psoriasis [Corrigendum], PMID: 26082656

Correction: T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab, PMID: 29381749

Severe recalcitrant psoriasis treated with itolizumab, a novel anti-CD6 monoclonal antibody, PMID: 27279321

A clinical exploratory study with itolizumab, an anti-CD6 monoclonal antibody, in patients with rheumatoid arthritis, PMID: 24371585

Rationale for treating primary Sjögren's syndrome patients with an anti-CD6 monoclonal antibody (Itolizumab), PMID: 23576060

Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, phase-III study, PMID: 24703722

Tailored treatment options for patients with psoriatic arthritis and psoriasis: review of established and new biologic and small molecule therapies, PMID: 26892034

Safety and Efficacy of Itolizumab in the Treatment of Psoriasis: A Case Series of 20 Patients, PMID: 28050487

Off-label Use of Itolizumab in Patients with COVID-19 ARDS: Our Clinical Experience in a Dedicated COVID Center, PMID: 34045817

Clinical Outcome of a Novel Anti-CD6 Biologic Itolizumab in Patients of Psoriasis with Comorbid Conditions, PMID: 27885324

T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab, PMID: 28672038

Itolizumab provides sustained remission in plaque psoriasis: a 5-year follow-up experience, PMID: 25495868

A Real-World Study to Assess the Effectiveness of Itolizumab in Patients with Chronic Plaque Psoriasis, PMID: 28761839

Immunological evaluation of rheumatoid arthritis patients treated with itolizumab, PMID: 26466969

The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial, PMID: 28963724

Itolizumab Treatment for Cytokine Release Syndrome in Moderate to Severe Acute Respiratory Distress Syndrome Due to COVID-19: Clinical Outcomes, A Retrospective Study, PMID: 33527804

Itolizumab - A New Biologic for Management of Psoriasis and Psoriatic Arthritis, PMID: 29033818

Itolizumab in combination with methotrexate modulates active rheumatoid arthritis: safety and efficacy from a phase 2, randomized, open-label, parallel-group, dose-ranging study, PMID: 26050104

Itolizumab in the Management of Psoriasis with Metabolic Syndrome, PMID: 28893023

An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients, PMID: 33292350

New Targeted Therapies for Uncontrolled Asthma, PMID: 31076057

Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab, PMID: 26844560

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis, PMID: 29271481

Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19, PMID: 33105142

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review, PMID: 33068263

Itolizumab - a humanized anti-CD6 monoclonal antibody with a better side effects profile for the treatment of psoriasis, PMID: 25945063

Are We Jumping the Gun with Itolizumab in India? A Situational Analysis from the Pre-COVID Era, PMID: 33015549

Treatment of COVID-19 patients with the anti-CD6 antibody itolizumab, PMID: 33304584

Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour?, PMID: 33048300

Itolizumab, a novel anti-CD6 monoclonal antibody: a safe and efficacious biologic agent for management of psoriasis, PMID: 28064543

Antibodies to watch in 2021, PMID: 33459118

Spotlight on itolizumab in the treatment of psoriasis - current perspectives from India, PMID: 31119094

Itolizumab in Psoriasis, PMID: 28794555

Possible treatment and strategies for COVID-19: review and assessment, PMID: 33336780

Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis, PMID: 33378357

Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications, PMID: 32700604

Datasheet

Document Download

Research Grade Itolizumab.pdf

 

$ 530
Product specifications
1 mg 530 5 mg 1590 25 mg 4130

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Research Grade Itolizumab [DHD87601]
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