Catalog No.
DHB95905
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Chimeric
Isotype
IgG4-lambda
Clonality
Monoclonal
Target
T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01730
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CE9, 4PE, IDEC-151, CAS: 182912-58-9
Clone ID
Clenoliximab
Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4, PMID: 10734150
A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis, PMID: 10511060
Antibody-mediated stripping of CD4 from lymphocyte cell surface in patients with rheumatoid arthritis, PMID: 12509613
Gateways to clinical trials, PMID: 14571286
Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4, PMID: 10657642
Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a nondepleting CD4 antibody, PMID: 10384148
CD4 mAb induced apoptosis of peripheral T cells: multiparameter subpopulation analysis by flow cytometry using Attractors, PMID: 11687240
Pharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins, PMID: 16187939
Inhibition of contact sensitivity in human CD4+ transgenic mice by human CD4-specific monoclonal antibodies: CD4+ T-cell depletion is not required, PMID: 10692049
Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees, PMID: 11161972
For research use only. Not for human or drug use.
