Catalog No.
FMK25210
Species reactivity
Mouse
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD16, CD32, Low affinity immunoglobulin gamma Fc region receptor III, IgG Fc receptor III, Fc-gamma RIII, FcRIII, CD16, Fcgr3, Low affinity immunoglobulin gamma Fc region receptor II, Fc gamma receptor IIB, Fc-gamma RII, Fc-gamma-RIIB, FcRII, IgG Fc receptor II beta, Lymphocyte antigen 17, Ly-17, CD32, Fcgr2, Fcgr2b, Ly-17, Fc Block
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
Fc Blocking, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
2.4G2
Suppression of Pathological Allergen-Specific B Cells by Protein-Engineered Molecules in a Mouse Model of Chronic House Dust Mite Allergy., PMID:39769423
Pre-Existing Humoral Immunity Enhances Epicutaneously-Administered Allergen Capture by Skin DC and Their Migration to Local Lymph Nodes., PMID:33868229
Anti-FcγRIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of FcγRIII., PMID:28624610
Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells., PMID:27868337
A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects., PMID:25752470
Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis., PMID:24139828
Development and characterisation of monoclonal antibodies specific for the murine inhibitory FcγRIIB (CD32B)., PMID:22760702
Exacerbation of collagen induced arthritis by Fcγ receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production., PMID:22532778
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes., PMID:20039297
Modulation of immune response by combined targeting of complement receptors and low-affinity Fcgamma receptors., PMID:20005256
CD16/32-specific biotinylated 2.4G2 single-chain Fv complexed with avidin-FITC enhances FITC-specific humoral immune response in vivo in a CD16-dependent manner., PMID:19951957
Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development., PMID:17013985
Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages., PMID:15316030
Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis through Fcgamma receptors., PMID:12419285
Expression of FcgammaRIII is required for development of collagen-induced arthritis., PMID:12355445
Antibody modulation of antigen presentation: positive and negative effects on presentation of the tetanus toxin antigen via the murine B cell isoform of FcgammaRII., PMID:11828370
Simultaneous blockade of Fc gamma receptors and indirect labeling of mouse lymphocytes by the selective detection of allotype-restricted epitopes on the kappa chain of rat monoclonal antibodies., PMID:11813200
Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia., PMID:11493456
Functional association of CD9 with the Fc gamma receptors in macrophages., PMID:11207280
Increased in vivo mitogenicity of anti-TCR/CD3 monoclonal antibody through reduced interaction with Fcgamma receptors., PMID:11137141
CD95 (Fas) ligand-expressing vesicles display antibody-mediated, FcR-dependent enhancement of cytotoxicity., PMID:11067901
The role of the DAP12 signal in mouse myeloid differentiation., PMID:11034384
Atopic asthma is dominant in elderly onset asthmatics: possibility for an alteration of mast cell function by aging through Fc receptor expression., PMID:10529610
Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice., PMID:10397735
Close localization of mouse CD14 and CD32/16 in the cell surface of monocytic cell lines., PMID:10023137
Alpha-2-macroglobulin receptor is differently expressed in peritoneal macrophages from C3H and C57/B16 mice and up-regulated during Trypanosoma cruzi infection., PMID:9787474
A regulatory role for Fcgamma receptors CD16 and CD32 in the development of murine B cells., PMID:9763567
Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries., PMID:9661816
Independent mechanisms for macrophage binding and macrophage phagocytosis of damaged erythrocytes. Evidence of receptor cooperativity., PMID:9437191
Fc gammaRII (CD32) is linked to apoptotic pathways in murine granulocyte precursors and mature eosinophils., PMID:9242561
Measles virus nucleocapsid protein binds to FcgammaRII and inhibits human B cell antibody production., PMID:9221756
Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62., PMID:9221755
Synthetic peptides from mouse Fc receptor (MoFc gamma RII) that alter the binding of IgG to MoFc gamma RII., PMID:9020795
IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells., PMID:8905407
A spontaneously immortalized mouse microglial cell line expressing CD4., PMID:8873987
Fc receptor off-signal in the B cell involves apoptosis., PMID:8683155
Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin., PMID:7664779
Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: a histological analysis using soluble immunoglobulin G-immune complexes and a monoclonal antibody (2.4G2)., PMID:7541388
Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects., PMID:7614975
Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus., PMID:7768529
Murine KIT+ lineage- bone marrow progenitors express Fc gamma-RII but do not express Fc epsilon-RI until mast cell granule formation., PMID:7527815
An alternative Fc gamma-receptor ligand: potential role in T-cell development., PMID:7809135
Immunophenotyping of murine peritoneal macrophages and lymphocytes by flow cytometry., PMID:8083515
Modulation of the Fc gamma RII and Fc gamma RIII induced by GM-CSF, IFN-gamma and IL-4 on murine eosinophils., PMID:7529744
Biological activities of murine low-affinity Fc receptors for IgG., PMID:8069527
Fc gamma R-mediated endocytosis and expression of cell surface Fc gamma RIIb1 and Fc gamma RIIb2 by mouse bone marrow culture-derived progenitor mast cells., PMID:8283054
Molecular mimicry between Fc receptors and viral antigens., PMID:7503651
An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4G2) decreases acute Trypanosoma cruzi infection in mice., PMID:8406898
Association constants of anti-hapten monoclonal IgG1 with mouse Fc gamma RII in the presence and absence of hapten., PMID:8224167
Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcR gamma II-mediated immune-complex trapping., PMID:8244461