Measles Virus (MeV)
2026-09-17 86

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Measles Virus (MeV)

Viral Structure, Key Antigen Targets and Research Applications

Measles virus structure (Viruses. 2016 Oct 22;8(10):294)

Overview

Measles virus (MeV) is an enveloped, negative-sense single-stranded RNA virus belonging to the genus Morbillivirus within the family Paramyxoviridae. It is the causative agent of measles, a highly contagious infectious disease. MeV research focuses on viral entry, replication, antigen recognition, immune responses, and antibody-mediated neutralization.

The viral surface glycoproteins Hemagglutinin (H) and Fusion protein (F) are key determinants of receptor binding and membrane fusion, making them important targets for studies of viral infection mechanisms and neutralizing antibodies.

The MeV genome is approximately 15.9 kb and encodes six major structural proteins: N (Nucleoprotein), P (Phosphoprotein), M (Matrix protein), F (Fusion protein), H (Hemagglutinin protein), and L (Large polymerase protein). These proteins coordinate viral attachment, entry, RNA replication, assembly, and release.

Measles Virus Structure

Measles virus is an enveloped, pleomorphic virus containing a non-segmented, negative-sense RNA genome. The viral envelope contains two major surface glycoproteins: H protein, responsible for receptor recognition, and F protein, which mediates membrane fusion.

Key Research Targets

H and F Glycoproteins Key Target

The Hemagglutinin (H) protein mediates recognition of host receptors, including CD150/SLAMF1 and nectin-4, initiating viral attachment. The Fusion (F) protein promotes membrane fusion between the virus and host cell after receptor engagement, enabling viral genome delivery. Due to their surface exposure and essential roles in infection, H and F proteins are widely studied in antibody recognition, neutralization assays, vaccine antigen evaluation, and viral entry studies.

Applications: Antibody recognition · Neutralization assays · Vaccine antigen evaluation · Viral entry studies

Antibody Neutralization Vaccine Entry

N, P, and L Proteins Replication

The Nucleoprotein (N) encapsulates the viral RNA genome and forms the ribonucleoprotein complex required for transcription and replication. The Phosphoprotein (P) and Large polymerase protein (L) form the viral RNA-dependent RNA polymerase complex responsible for viral RNA synthesis. These proteins are important targets for viral replication studies, antigen detection, and molecular virology research.

Applications: Viral replication studies · Antigen detection · Molecular virology research

Replication Antigen detection Virology

Matrix Protein (M) Assembly

The Matrix protein (M) connects viral nucleocapsids with envelope components and contributes to viral assembly and budding. M protein studies provide insights into virion formation, viral morphogenesis, and virus assembly mechanisms.

Applications: Virion formation · Viral morphogenesis · Virus assembly mechanisms

Virion formation Assembly

Key Research Targets of Measles Virus

Target	Major Function	Research Applications
H	Receptor binding and attachment	Antibody studies, neutralization, vaccine research
F	Membrane fusion and viral entry	Fusion mechanism, antibody research
N	RNA genome encapsulation	Antigen detection, replication studies
P/L	Viral RNA polymerase complex	Viral replication and antiviral research
M	Viral assembly and budding	Virion formation studies

Note: H and F glycoproteins are the primary targets for neutralizing antibodies and vaccine development, while N, P, and L are essential for viral replication and molecular virology research.

AntibodySystem Measles Virus Research Products

AntibodySystem provides research reagents targeting key Measles virus proteins for studies of viral antigenicity, antibody recognition, and assay development.

Measles Virus Antigens

Cat. No.	Product Name
EVV33901	Recombinant MeV H/Hemagglutinin glycoprotein Protein, C-His
YVV33901	Recombinant MeV H/Hemagglutinin glycoprotein Protein, N-His
YVV34501	Recombinant MeV F1/Fusion glycoprotein F1 Protein, N-His
YVV34601	Recombinant MeV N/Nucleoprotein Protein, N-His
YVV34701	Recombinant MeV M/Matrix protein Protein, N-His
YVV34801	Recombinant MeV P/Phosphoprotein Protein, N-His
YVV34901	Recombinant MeV V/Non-structural protein V Protein, N-His
YVV35001	Recombinant MeV C/Protein C Protein, N-His

Measles Virus Antibodies

Cat. No.	Product Name
VVV34502	Anti-MeV F/Fusion glycoprotein F0 Antibody (m1Y76)
VVV34501	Anti-MeV F/Fusion glycoprotein F0 Antibody (m1Y75)
VVV33902	Anti-MeV H/Hemagglutinin glycoprotein Antibody (m1Y74)
VVV33901	Anti-MeV H/Hemagglutinin glycoprotein Antibody (m1Y73)
PVV34901	Anti-MeV V/Non-structural protein V Polyclonal Antibody
PVV34601	Anti-MeV N/Nucleoprotein Polyclonal Antibody

AntibodySystem — Reliable Reagents for Measles Virus Research

AntibodySystem offers high-quality recombinant proteins and antibodies to support Measles virus antigen characterization, antibody screening, vaccine studies, and diagnostic assay development.

Measles Products →

Measles Virus · Research Resource

Measles Virus (MeV) 2026-09-17 86