Monkeypox Virus, MPXV
Viral Structure, Key Antigen Targets and Research Applications
MPXV structure
Overview of MPXV
MPXV formerly known as monkeypox virus, is an enveloped double-stranded DNA virus belonging to the genus Orthopoxvirus within the family Poxviridae.
MPXV is the causative agent of mpox, a zoonotic disease characterized by fever, lymphadenopathy, skin lesions, and systemic symptoms. In recent years, global outbreaks of mpox have increased scientific interest in viral transmission mechanisms, host-virus interactions, immune responses, antiviral strategies, and vaccine development.
Unlike many DNA viruses, orthopoxviruses replicate entirely within the cytoplasm of infected cells. MPXV contains a large double-stranded DNA genome encoding more than 200 viral proteins involved in viral entry, replication, assembly, immune modulation, and host adaptation.
Among these viral proteins, A35R, A29L, M1R, B6R, E8L, and F3L are important research targets widely investigated for antigen characterization, antibody development, vaccine studies, and immunological analysis.
MPXV Structure
MPXV is a large and complex enveloped virus with a characteristic brick-shaped or oval morphology.
The viral particle consists of:
- Outer lipid envelope
- Viral membrane proteins
- Protein capsid structure
- Core containing viral DNA genome
- Viral proteins involved in replication and immune regulation
The MPXV genome is a linear double-stranded DNA molecule of approximately 197 kb and encodes a large number of proteins involved in viral replication, host immune evasion, and viral particle formation.
Key MPXV Research Targets
- Due to its immunogenicity and role in viral infection, A35R is widely studied in vaccine development and antibody response analysis.
- Because of its role during early infection stages, A29L is an important target for studying viral entry mechanisms and antibody responses.
- Studies targeting M1R contribute to understanding MPXV particle formation and immune recognition mechanisms.
- B6R-specific antibodies are widely used in studies investigating MPXV antigenicity, immune responses, and vaccine-induced protection.
- Research targeting E8L provides insights into MPXV infection mechanisms and antibody-mediated recognition.
- Studies of F3L contribute to understanding MPXV replication mechanisms and antiviral research.
Key MPXV Research Targets
| Target | Biological Function | Research Applications |
|---|---|---|
| A35R Protein | Membrane-associated antigen involved in immune recognition | Vaccine research, antibody development, antigen characterization |
| A29L Protein | Conserved protein involved in viral attachment and entry | Viral entry studies, antibody evaluation |
| M1R Protein | Structural protein involved in viral assembly | Viral structure studies, vaccine research |
| B6R Protein | Immunogenic protein recognized by host immunity | Immune response analysis, antibody studies |
| E8L Protein | Conserved protein involved in viral attachment | Infection mechanism studies, antibody development |
| F3L Protein | Viral protein involved in replication and host interaction | Antiviral research, replication studies |
Citations
AntibodySystem MPXV related products have been cited in peer-reviewed publications, supporting MPXV antigen research, antibody evaluation, vaccine studies, and immunological analysis.
| DOI / PMID | Cat. No. | Product Name |
|---|---|---|
| PMID: 36947428 |
Mouse Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285); Mouse Anti-Monkeypox virus/MPXV A35R Antibody (SAA0287); Mouse Anti-Monkeypox virus/MPXV M1R Antibody (SAA0283) |
|
| PMID: 37128898 | KAV13401 | Human Anti-Monkeypox Virus (MPXV) IgG ELISA Kit (A29L) |
| PMCID: PMC11184329 |
Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody; Anti-Monkeypox virus/MPXV A35R Polyclonal Antibody; Anti-Monkeypox virus/MPXV A29L Polyclonal Antibody; Anti-Monkeypox virus/MPXV M1R Polyclonal Antibody |
|
| PMCID: PMC11680392 |
Mouse Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285); Mouse Anti-Monkeypox virus/MPXV M1R Antibody (SAA0283); Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody |
|
| PMID: 39861905 |
Recombinant Monkeypox virus/MPXV A35R Protein C-His; Mouse Anti-Monkeypox virus/MPXV A35R Antibody |
|
| PMID: 40333228 |
Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody; Mouse Anti-Monkeypox virus/MPXV M1R Antibody (SAA0283) |
|
| PMID: 40498864 | PVV13501 | Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody |
| PMID: 40651557 |
Anti-Monkeypox virus/MPXV F3L Polyclonal Antibody; Mouse Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285) |
|
| PMID: 40783493 | PVV13101 | Anti-Monkeypox virus/MPXV A35R Polyclonal Antibody |
| PMID: 41144710 |
Anti-Monkeypox virus/MPXV F3L Polyclonal Antibody; Anti-Monkeypox virus/MPXV E8L Polyclonal Antibody |
|
| PMID: 41181874 |
Anti-Monkeypox virus/MPXV F3L Polyclonal Antibody; Mouse Anti-Monkeypox virus/MPXV E8L Antibody (SAA0285) |
|
| PMID: 41583908 |
Recombinant Monkeypox virus/MPXV A35R Protein C-His; Recombinant Monkeypox virus/MPXV M1R Protein C-His |
AntibodySystem MPXV Products
AntibodySystem provides recombinant antigens, antibodies, and ELISA kits targeting key MPXV proteins to support viral research, antigen characterization, antibody development, vaccine studies, and immunological analysis.
MPXV Antigens
| Cat. No. | Product Name |
|---|---|
| EVV13101 | Recombinant Monkeypox virus/MPXV A35R Protein C-His |
| EVV13301 | Recombinant Monkeypox virus/MPXV M1R Protein C-His |
MPXV Antibodies
| Cat. No. | Product Name |
|---|---|
| PVV13501 | Anti-Monkeypox virus/MPXV B6R/SL-159 Polyclonal Antibody |
| PVV13101 | Anti-Monkeypox virus/MPXV A35R Polyclonal Antibody |
| PVV13401 | Anti-Monkeypox virus/MPXV A29L Polyclonal Antibody |
| PVV13301 | Anti-Monkeypox virus/MPXV M1R Polyclonal Antibody |
| PVV14801 | Anti-Monkeypox virus/MPXV F3L Polyclonal Antibody |
| RVV13201 | Anti-Monkeypox virus/MPXV E8L Polyclonal Antibody |
MPXV ELISA Kits
| Cat. No. | Product Name |
|---|---|
| KAV13401 | Human Anti-Monkeypox Virus (MPXV) IgG ELISA Kit (A29L) |
AntibodySystem supporting MPXV Research
AntibodySystem is committed to providing high-quality antigens, antibodies, and immunoassay reagents to support MPXV research, including viral antigen characterization, antibody screening, vaccine-related studies, immune response analysis, and assay development.
AntibodySystem — Reliable Reagents for Viral Research
