DNA & RNA Research Antibodies
DNA and RNA are more than genetic information carriers. Beyond their canonical forms, nucleic acids can adopt diverse structures, including DNA-RNA hybrids, G-quadruplexes (G4), Z-DNA/Z-RNA, and dsRNA, which play important roles in gene regulation, genome stability, and viral infection. However, many of these structures are dynamic and difficult to detect using conventional methods.
AntibodySystem DNA/RNA Research Antibodies provide structure-specific tools for studying R-loops, G4 structures, Z-DNA/Z-RNA, and RNA biology.
AntibodySystem DNA/RNA Research Antibodies provide structure-specific tools for studying R-loops, G4 structures, Z-DNA/Z-RNA, and RNA biology.
S9.6 Antibody Classic R-loop Tool
R-loops are three-stranded structures (DNA-RNA hybrid + displaced ssDNA) involved in transcription and chromatin organization. Abnormal R-loops cause genome instability and are linked to cancer and neurological disorders. Anti-DNA-RNA Hybrid Antibody (S9.6) specifically recognizes DNA-RNA hybrids and is widely used in DRIP-seq, ChIP-seq, IF/FISH, and more.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK60001 | Anti-DNA-RNA Hybrid Antibody (S9.6) | ChIP, ChIP-seq, DRIP, EMSA, FISH, ICC, IF, IP, SPR |
Customer Publication
1. Anti-DNA-RNA Hybrid Antibody (S9.6) [RGK60001] PMID: 40919700
2. Anti-DNA-RNA Hybrid Antibody (S9.6) [RGK60001] PMID: 41360772
BG4 Antibody G-quadruplex (G4) Detection
G-quadruplexes are four-stranded structures formed by guanine-rich sequences, found in telomeres, oncogene promoters, and regulatory regions. They influence replication, transcription, and are emerging cancer targets. Anti-DNA/RNA G-quadruplex Structures Antibody (BG4) specifically recognizes DNA/RNA G4 structures.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK60301 | Anti-DNA/RNA G-quadruplex Structures Antibody (BG4) | ELISA, EMSA, IF, ChIP-seq, WB |
| RGK60307 | Anti-DNA/RNA G-quadruplex Structures Antibody (BG4) | ELISA, EMSA, ICC, IF, ChIP (ChIP-seq), WB |
| RGK60305 | Anti-G-quadruplex DNA Antibody (4E11#) | DB, ELISA, IF |
| RGK60306 | Anti-G-quadruplex DNA Antibody (1H6) | DB, ELISA, IF |
| RGK60308 | Anti-G-quadruplex DNA Nanobody (SAb2479) | ELISA |
Customer Publication
1. Anti-DNA/RNA G-quadruplex Structures Antibody (BG4) [RGK60301] PMID: 41689056
2. Anti-DNA/RNA G-quadruplex Structures Antibody (BG4) [RGK60301] PMID: 36640595
Z-DNA/Z-RNA Antibody Alternative Conformations
Z-DNA and Z-RNA are left-handed helical structures that form under certain sequence and cellular conditions. They are associated with transcription, metabolism, and immune responses. Anti-Z-DNA/Z-RNA Antibody (Z22) enables detection of these non-canonical conformations.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK24302 | Anti-Z-DNA/Z-RNA Antibody (Z22) | DB, ELISA, EMSA, FCM, FuncS, IF, IHC, SPR |
Customer Publication
1. Anti-Z-DNA/Z-RNA Antibody (Z22) [RGK24302] PMID: 40769147
dsRNA Antibodies Viral Immunity & RNA Structure
Double-stranded RNA (dsRNA) is a key intermediate in RNA virus replication and a potent innate immune signal. AntibodySystem offers a panel of anti-dsRNA antibodies (clones J2, K1, K2, 1D3, etc.) and a dsRNA ELISA Kit for studying viral infection, RNA metabolism, and immune signaling.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK24901 | Anti-dsRNA Antibody (1D3) | DB, ELISA, IF |
| RGK24902 | Anti-dsRNA Antibody (10G1) | DB, ELISA, IF |
| RGK24903 | Anti-dsRNA Antibody (9D5) | DB, ELISA, IF |
| RGK24904 | Anti-dsRNA Antibody (6G9) | DB, ELISA, IF |
| RGK24905 | Anti-dsRNA Antibody (10B2) | ELISA |
| RGK24910 | Anti-dsRNA Antibody (SAb2564) | DB, ELISA, IF |
| RGK24906 | Anti-dsRNA Antibody (J2) | DB, ELISA (Cap), IF |
| RGK24907 | Anti-dsRNA Antibody (K1) | ELISA (Dec), IF |
| RGK24908 | Anti-dsRNA Antibody (K2) | ELISA, IF |
| KGK24901 | dsRNA ELISA Kit | — |
Customer Publication
1. Anti-dsRNA Antibody (1D3) [RGK24901] PMID: 39591170
dsDNA Antibodies Double-stranded DNA Research
dsDNA is the primary form of genomic DNA. dsDNA antibodies are used for DNA detection, nuclear staining, autoimmune research, and DNA-related studies. AntibodySystem offers several dsDNA antibodies and ELISA kits.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK24020 | Anti-dsDNA Antibody (3E10#) | DB, ELISA, IF |
| RGK24021 | Anti-dsDNA hIgG Antibody (3E10#) | IB, ELISA, SPR |
| RGK23954 | Anti-B-DNA Antibody (Fs0492) | ELISA, IF, FCM |
| KAK24001 | Anti-dsDNA Mouse IgG ELISA Kit | — |
| KGK24001 | dsDNA ELISA Kit | — |
Customer Publication
1. Anti-dsDNA Antibody (3E10#) [RGK24020] DOI: 10.1002/adfm.202422817
2. Anti-dsDNA Antibody (3E10#) [RGK24020] PMID: 41687841
ssDNA / ssRNA Antibodies Single-stranded Dynamics
ssDNA and ssRNA are transient intermediates in replication, repair, transcription, and viral replication. AntibodySystem provides specific antibodies to monitor single-stranded nucleic acid dynamics.
| Catalog No. | Product Name | Applications |
|---|---|---|
| RGK24118 | Anti-ssDNA Antibody (S1-15) | ELISA |
| RGK25001 | Anti-ssRNA Antibody (JEL103) | DB, ELISA |
| RGK25002 | Anti-ssRNA Antibody (BRG) | DB, ELISA, IF |
| RGK25003 | Anti-ssRNA Antibody (cAbBC1rib3) | DB, ELISA, IF |
| RGK25004 | Anti-ssRNA Antibody (cAbBC1rib90) | DB, ELISA, IF |
| RGK25005 | Anti-ssRNA Antibody (cAbBC1rib20) | DB, ELISA, IF |
DNA Antibodies General DNA Research
General anti-DNA antibodies are used for DNA localization, chromatin studies, and DNA-protein interaction assays. Available clones include BKV29, BKV39, B8801, and clone 50.
RNA Antibodies RNA Biology & Regulation
RNA antibodies enable detection and analysis of RNA molecules in cells, supporting studies of gene regulation, RNA processing, viral replication, and immune recognition.
From Sequence to Structure: A New Perspective on DNA and RNA Biology
Genetic information is not only encoded in DNA sequences. Increasing evidence shows that nucleic acid structures themselves play important roles in regulating cellular states and disease development. From R-loops and G-quadruplexes to Z-DNA/Z-RNA and dsRNA, these previously difficult-to-detect structures are becoming important windows for understanding genome regulation, RNA biology, and disease mechanisms.
The AntibodySystem DNA/RNA Research Antibodies portfolio provides researchers with structure-specific nucleic acid detection tools to investigate genome stability, RNA regulation, and the molecular mechanisms underlying human disease.
The AntibodySystem DNA/RNA Research Antibodies portfolio provides researchers with structure-specific nucleic acid detection tools to investigate genome stability, RNA regulation, and the molecular mechanisms underlying human disease.
