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Research Grade Anti-HIV gp120SU (VRC01) (DVV07801)

Host species:Human
Isotype:IgG1
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DVV07801

Expression system

Mammalian Cells

Species reactivity

Human immunodeficiency virus 1

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

gp120SU

Concentration

2.57 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q75760, Q2N0S6, C6ZIG9

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

VRC01

Data Image
  • SDS-PAGE
    SDS PAGE for HIV gp120/SU (VRC01) Antibody
References

The GP120 molecule of HIV-1 and its interaction with T cells. PMID: 20088758

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. PMID: 9641677

HIV-1 gp120 and immune network. PMID: 15370273

HIV-1 gp120: a novel viral B cell superantigen. PMID: 9186784

HIV gp120: double lock strategy foils host defences. PMID: 9739096

Immune responses to HIV Gp120 that facilitate viral escape. PMID: 17266556

Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury. PMID: 22124968

Entry inhibitors directed towards glycoprotein gp120: an overview on a promising target for HIV-1 therapy. PMID: 23278399

Glycosylation of HIV-1 gp120 V3 loop: towards the rational design of a synthetic carbohydrate vaccine. PMID: 18220757

HIV gp120 induced gene expression signatures in vaginal epithelial cells. PMID: 23867815

HIV-1 proteins gp120 and tat induce the epithelial-mesenchymal transition in oral and genital mucosal epithelial cells. PMID: 31869348

Mechanisms of Blood-Retinal Barrier Disruption by HIV-1. PMID: 30873925

Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements. PMID: 34246921

HIV gp120 interactions with coreceptors: insights from studies with CCR5-based peptides. PMID: 17933721

Interactions of HIV gp120 with the CD4 molecule on lymphocytes and in the nervous system. PMID: 2198840

Gp120 substitutions at positions associated with resistance to fostemsavir in treatment-naive HIV-1-positive individuals. PMID: 32191306

The role of the V3 loop of gp120 in HIV infection. PMID: 1845049

The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection. PMID: 33288704

Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice. PMID: 23252824

HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells. PMID: 22954308

HIV-1 gp120 dimers decrease the overall affinity of gp120 preparations for CD4-induced ligands. PMID: 25712564

HIV vaccine candidates. PMID: 15645007

Multiple binding modes of an N-terminal CCR5-peptide in complex with HIV-1 gp120. PMID: 34921512

Computational design, synthesis and evaluation of new sulphonamide derivatives targeting HIV-1 gp120. PMID: 31792886

NMR observation of HIV-1 gp120 conformational flexibility resulting from V3 truncation. PMID: 24819826

Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity. PMID: 23297802

High level stable expression of recombinant HIV gp120 in glutamine synthetase gene deficient HEK293T cells. PMID: 33529763

HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. PMID: 23011758

CD4-binding obstacles in conformational transitions and allosteric communications of HIV gp120. PMID: 32061646

Substance abuse and HIV-gp120: are opiates protective? PMID: 10202562

Identification of Novel Potential gp120 of HIV-1 Antagonist Using Per-Residue Energy Contribution-Based Pharmacophore modelling. PMID: 27165479

V3: HIV's switch-hitter. PMID: 15725757

Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region. PMID: 29346393

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. PMID: 22451932

Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues. PMID: 25453804

Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice. PMID: 25652249

HIV gp120 receptors on human dendritic cells. PMID: 11588046

HIV-1 gp120 envelope protein modulates proliferation of human glomerular epithelial cells. PMID: 10581001

Allosteric induction of the CD4-bound conformation of HIV-1 Gp120. PMID: 24304511

Tubular cell HIV-1 gp120 expression induces caspase 8 activation and apoptosis. PMID: 19462280

Comparative glycoprofiling of HIV gp120 immunogens by capillary electrophoresis and MALDI mass spectrometry. PMID: 25809283

Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus. PMID: 24120859

The antigenic structure of the HIV gp120 envelope glycoprotein. PMID: 9641684

gp120 sequences from HIV type 1 subtype C early seroconverters in India. PMID: 15320993

HIV unbound. PMID: 15812519

Opening dynamics of HIV-1 gp120 upon receptor binding is dictated by a key hydrophobic core. PMID: 31764922

HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection. PMID: 19698075

Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564. PMID: 15207637

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay. PMID: 24158809

Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120. PMID: 21600706

The influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop. PMID: 24303005

Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors. PMID: 23487463

Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor. PMID: 34372601

An antibody-recruiting small molecule that targets HIV gp120. PMID: 19839582

A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4. PMID: 28429756

Molecular recognition of CXCR4 by a dual tropic HIV-1 gp120 V3 loop. PMID: 24048002

Structural Analysis of the Glycosylated Intact HIV-1 gp120-b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting. PMID: 28102671

HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug. PMID: 22615295

HIV-gp120 can block CD4-class II MHC-mediated adhesion. PMID: 1967269

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120. PMID: 22230366

Molecular architecture of native HIV-1 gp120 trimers. PMID: 18668044

A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4. PMID: 8663408

Structural plasticity and conformational transitions of HIV envelope glycoprotein gp120. PMID: 23300605

Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. PMID: 25797607

Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120. PMID: 12665517

Targeting of HIV gp120 by oligonucleotide-photosensitizer conjugates. Light-induced damages. PMID: 10622747

The HIV-1 gp120 major variable regions modulate cold inactivation. PMID: 23345516

Isobaric tagging-based quantification by mass spectrometry of differentially regulated proteins in synaptosomes of HIV/gp120 transgenic mice: implications for HIV-associated neurodegeneration. PMID: 22575597

Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication. PMID: 16227233

Solution structure, conformational dynamics, and CD4-induced activation in full-length, glycosylated, monomeric HIV gp120. PMID: 22674993

Receptor binding domain based HIV vaccines. PMID: 25667925

HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium. PMID: 11445868

HIV N-linked glycosylation site analyzer and its further usage in anchored alignment. PMID: 23748959

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120. PMID: 29463753

Inhibition of V3-specific cleavage of recombinant HIV-1 gp120 produced in Chinese hamster ovary cells. PMID: 18406166

Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding. PMID: 21488663

Role of the HIV gp120 conserved domain 5 in processing and viral entry. PMID: 18597484

The characteristic structure of anti-HIV actinohivin in complex with three HMTG D1 chains of HIV-gp120. PMID: 25403811

Role of the HIV gp120 conserved domain 1 in processing and viral entry. PMID: 18815131

Theoretical studies on the interactions and interferences of HIV-1 glycoprotein gp120 and its coreceptor CCR5. PMID: 21284403

Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments. PMID: 22117536

Probing the HIV gp120 envelope glycoprotein conformation by NMR. PMID: 21592971

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Anti-HIV gp120SU (VRC01) [DVV07801]
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