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Research Grade Visilizumab

Catalog #:   DHC27704 Specific References (99) DATASHEET
Host species: Humanized
Isotype: IgG2-nd
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC27704

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-nd

Clonality

Monoclonal

Applications

Research Grade Biosimilar

Target

T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07766

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

HuM291, CAS: 219716-33-3

Clone ID

Visilizumab

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
  • SDS-PAGE
    SDS PAGE for Visilizumab
References

A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease., PMID:15931635

Update in medical therapy of ulcerative colitis: newer concepts and therapies., PMID:16000921

Gateways to clinical trials., PMID:16082427

Advances in medical therapy of inflammatory bowel disease., PMID:16213789

Can super-antibody drugs be tamed?, PMID:16612349

Digestive Disease Week 2006. Therapies for Crohn's disease and ulcerative colitis. 21-15 May 2006, Los Angeles, CA, USA., PMID:16821150

Management of acute severe colitis., PMID:16847166

Novel biological therapies for inflammatory bowel disease., PMID:16901384

Review article: saving the colon in severe colitis - the case for medical therapy., PMID:16961749

Advances in biologic therapy for ulcerative colitis and Crohn's disease., PMID:17105690

General principles and pharmacology of biologics in inflammatory bowel disease., PMID:17129812

Biological agents for ulcerative colitis: hypes and hopes., PMID:17464967

Inflammatory bowel disease: clinical aspects and established and evolving therapies., PMID:17499606

A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis., PMID:17920064

[The role of translational research in inflammatory bowel disease]., PMID:17966376

Assessing the risk of epstein-barr virus-related lymphoproliferative disorders before administration of visilizumab., PMID:18325408

Visilizumab in severe ulcerative colitis: good vision but blurry results., PMID:18383522

Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways., PMID:18424236

[The role of extracellular domain of human 4-1BBL in regulating activities of human peripheral blood lymphocytes in vitro]., PMID:18466693

Therapy of ulcerative colitis: state of the art., PMID:18622161

DNA repair after DNA fragmentation in mouse small intestinal epithelial cells., PMID:19015882

Therapeutic options in acute severe ulcerative colitis., PMID:19072385

Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease., PMID:19240707

[Biotherapy of auto-immune diseases : past, present and future perspectives]., PMID:19303737

Anti-CD3 mAbs for treatment of type 1 diabetes., PMID:19319985

Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis., PMID:19714757

Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes., PMID:19759100

[Pyoderma gangrenosum treated successfully with visilizumab in patients with ulcerative colitis]., PMID:20071320

In vitro analyses of the immunosuppressive properties of neural stem/progenitor cells using anti-CD3/CD28-activated T cells., PMID:20941615

Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis., PMID:20947884

Pyoderma gangraenosum., PMID:21037478

Gateways to clinical trials., PMID:21069103

IBD: Visilizumab not useful for intravenous steroid-refractory ulcerative colitis., PMID:21265059

IBD in 2010: optimizing treatment and minimizing adverse events., PMID:21293506

Oral anti-CD3 monoclonal antibody delays diabetes in non-obese diabetic (NOD) mice: effects on pregnancy and offspring--a preliminary report., PMID:21484981

Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?, PMID:21785616

Immunotherapy in inflammatory bowel disease., PMID:22703854

The use of monoclonal antibodies in immune-mediated hematologic disorders., PMID:22703857

Combination therapies in the context of anti-CD3 antibodies for the treatment of autoimmune diseases., PMID:23254986

Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells., PMID:23750800

Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice., PMID:24403315

Fine tuning effector and regulatory T-cell dynamics: a novel tool for plaque regression?, PMID:24556952

Systematic review of the effectiveness of biological therapy for active moderate to severe ulcerative colitis., PMID:24955447

Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation., PMID:25646305

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside., PMID:27161438

Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors., PMID:27991896

Emerging treatments for ulcerative colitis: a systematic review., PMID:28503977

Targeting T cells in inflammatory bowel disease., PMID:32585338

Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8+ T cells in early clinical stages of chronic lymphocytic leukemia., PMID:32710227

Tissue repair and ulcer/wound healing - Institut Pasteur Euroconference: molecular mechanisms, therapeutic targets and future directions, PMID: 15883915

[Biotherapy of auto-immune diseases : past, present and future perspectives], PMID: 19303737

[The role of translational research in inflammatory bowel disease], PMID: 17966376

Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice, PMID: 24403315

In vitro analyses of the immunosuppressive properties of neural stem/progenitor cells using anti-CD3/CD28-activated T cells, PMID: 20941615

Can super-antibody drugs be tamed?, PMID: 16612349

Review article: saving the colon in severe colitis - the case for medical therapy, PMID: 16961749

Medical therapy for ulcerative colitis: the state of the art and beyond, PMID: 15527679

Gateways to clinical trials, PMID: 12224444

Blockade of PD-1 and TIM-3 immune checkpoints fails to restore the function of exhausted CD8 + T cells in early clinical stages of chronic lymphocytic leukemia, PMID: 32710227

Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?, PMID: 21785616

Gateways to clinical trials, PMID: 12949633

Gateways to clinical trials, PMID: 16082427

General principles and pharmacology of biologics in inflammatory bowel disease, PMID: 17129812

Gateways to clinical trials, PMID: 21069103

Systematic review of the effectiveness of biological therapy for active moderate to severe ulcerative colitis, PMID: 24955447

Novel therapeutics for the treatment of graft-versus-host disease, PMID: 12225248

Biological agents for ulcerative colitis: hypes and hopes, PMID: 17464967

Update in medical therapy of ulcerative colitis: newer concepts and therapies, PMID: 16000921

IBD in 2010: optimizing treatment and minimizing adverse events, PMID: 21293506

The use of monoclonal antibodies in immune-mediated hematologic disorders, PMID: 22703857

Steroid-refractory graft-vs.-host disease: past, present and future, PMID: 12603689

Therapeutic options in acute severe ulcerative colitis, PMID: 19072385

Combination therapies in the context of anti-CD3 antibodies for the treatment of autoimmune diseases, PMID: 23254986

Monoclonal antibodies for the prevention and treatment of graft-versus-host disease, PMID: 12939720

Therapy of ulcerative colitis: state of the art, PMID: 18622161

Advances in biologic therapy for ulcerative colitis and Crohn's disease, PMID: 17105690

Advances in medical therapy of inflammatory bowel disease, PMID: 16213789

Anti-CD3 mAbs for treatment of type 1 diabetes, PMID: 19319985

Management of acute severe colitis, PMID: 16847166

Immunotherapy in inflammatory bowel disease, PMID: 22703854

Visilizumab in severe ulcerative colitis: good vision but blurry results, PMID: 18383522

Emerging treatments for ulcerative colitis: a systematic review, PMID: 28503977

Pyoderma gangraenosum, PMID: 21037478

Assessing the risk of epstein-barr virus-related lymphoproliferative disorders before administration of visilizumab, PMID: 18325408

Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease, PMID: 19240707

A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease, PMID: 15931635

Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis, PMID: 19714757

A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis, PMID: 17920064

IBD: Visilizumab not useful for intravenous steroid-refractory ulcerative colitis, PMID: 21265059

[Pyoderma gangrenosum treated successfully with visilizumab in patients with ulcerative colitis], PMID: 20071320

A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease, PMID: 11929757

Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes, PMID: 19759100

Inflammatory bowel disease: clinical aspects and established and evolving therapies, PMID: 17499606

Visilizumab with tacrolimus and methotrexate for GvHD prevention after allogeneic hematopoietic cell transplantation from mismatched unrelated donors, PMID: 27991896

Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis, PMID: 20947884

Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways, PMID: 18424236

Targeting T cells in inflammatory bowel disease, PMID: 32585338

99m Tc-Labeled succinimidyl-6-hydrazinonicotinate hydrochloride (SHNH)-conjugated visilizumab, PMID: 20641817

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside, PMID: 27161438

Datasheet

Document Download

Research Grade Visilizumab.pdf

 

$ 530
Product specifications
1 mg 530 5 mg 1590 25 mg 4130

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