Catalog No.
PHA62601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SPINT2 (Ala28-Lys197).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SPINT2,Placental bikunin,Hepatocyte growth factor activator inhibitor type 2,Kunitz-type protease inhibitor 2,HAI-2,HAI2,KOP
Purification
Purified by antigen affinity column.
Accession
O43291
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Single-cell RNA sequencing analysis of T helper cell differentiation and heterogeneity., PMID:35779629
Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma., PMID:31737572
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin., PMID:29438412
Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2., PMID:28125689
Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation., PMID:27043831
N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin., PMID:26171609
Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells., PMID:25786220
Novel host genetic variations associated with spontaneous clearance of a single-source outbreak of HCV1b infections., PMID:26462265
Loss of the matriptase inhibitor HAI-2 during prostate cancer progression., PMID:20687215
Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis., PMID:16574935
Plasma bikunin as a favorable prognostic factor in ovarian cancer., PMID:15735122
Urinary excretion of N-acetyl-beta-D-glucosaminidase and alpha1-microglobulin in children with proliferative blood diseases., PMID:15315013
Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease., PMID:14749682
The hepatocyte growth factor regulatory factors in human breast cancer., PMID:14734471
Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis., PMID:12964125
Urinary proteins in multiple myeloma: correlation with clinical parameters and diagnostic implications., PMID:12838370
Transforming growth factor-beta1 produced by ovarian cancer cell line HRA stimulates attachment and invasion through an up-regulation of plasminogen activator inhibitor type-1 in human peritoneal mesothelial cells., PMID:12743121
Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis., PMID:12553733
Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis., PMID:12522575
Classification of renal proteinuria: a simple algorithm., PMID:12521234
Evaluation of renal glomerular and tubular functional and structural integrity in neonates., PMID:12449447
Link protein as an enhancer of cumulus cell-oocyte complex expansion., PMID:12203832
Renal effects of cardiopulmonary bypass in the elderly., PMID:12017389
Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells., PMID:11777908
Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes., PMID:11606055
Expression of inter-alpha inhibitor related proteins in kidneys and urine of hyperoxaluric rats., PMID:11342956
Changes of urinary alpha1-microglobulin in the assessment of prognosis in renal transplant recipients., PMID:11063333
Carbohydrate groups of alpha1-microglobulin are important for secretion and tissue localization but not for immunological properties., PMID:10988251
Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia., PMID:10741912
Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound., PMID:10631976
Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue., PMID:10567446
Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity., PMID:10490808
Bikunin, a serine protease inhibitor, is present on the cell boundary of epidermis., PMID:10469301
Alpha-1-microglobulin: inhibitory effect on calcium oxalate crystallization in vitro and decreased urinary concentration in calcium oxalate stone formers., PMID:10460893
Immunohistochemical demonstration of inter-alpha-trypsin inhibitor light chain (bikunin) in human mast cells., PMID:10398892
Role of inter-alpha-inhibitor and its related proteins in urolithiasis. Purification of an inter-alpha-inhibitor related protein from the bovine kidney., PMID:10092154
Alpha1-microglobulin is found both in blood and in most tissues., PMID:9671439
Differential expression of urinary inter-alpha-trypsin inhibitor trimers and dimers in normal compared to active calcium oxalate stone forming men., PMID:9554330
Strong crossreaction of human anti-aprotinin antibodies from heart transplant patient with [Arg15]aprotinin., PMID:9043935
Identification of uronic-acid-rich protein as urinary bikunin, the light chain of inter-alpha-inhibitor., PMID:8665922
Inter-alpha-inhibitor: a protein family involved in the inhibition of calcium oxalate crystallization., PMID:9813621
Expression of rat alpha 1-microglobulin-bikunin in baculovirus-transformed insect cells., PMID:8527928
Human leucocyte elastase (HLE) preferentially cleaves the heavy chain H2 of inter-alpha-trypsin inhibitor (ITI)., PMID:7505589
Electrophoretic pattern of the inter-alpha-inhibitor family proteins in human serum, characterized by chain-specific antibodies., PMID:1384549
Biosynthesis of bikunin (urinary trypsin inhibitor) in rat hepatocytes., PMID:1586149
For research use only. Not for human or drug use.
