Catalog No.
RGK11202
Description
Chimeric P3 antibody specifically reacted with GM3(NeuGc) and GM2(NeuGc) gangliosides, and not with their acetylated variants.The chimeric antibody chP3 selectively recognizes a broad variety of NeuGc gangliosides, showing no cross-reactivity to the highly similar N-acetylated (NeuAc) gangliosidesWe have further investigated the interaction of chP3 with its anti-idiotypic antibody, 1E10 (also known as Racotumomab), currently in clinical trials as a cancer vaccine.
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
NeuGcGM3, Ganglioside N-glycolyl GM3, N-glycolylneuraminic acid -NeuGc, NGNA-GM3 ganglioside, NeuGcGM3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
ChEBI ID： 84118
Applications
ELISA, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
chP3
Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody. PMID: 19748674
Monoclonal antibody specific to alpha-2-->3-linked deaminated neuraminyl beta-galactosyl sequence. PMID: 8448384
Generation and characterization of an anti-idiotype monoclonal antibody related to GM3(NeuGc) ganglioside. PMID: 14678648
Cancer vaccines: an update with special focus on ganglioside antigens. PMID: 11836591
Chimeric anti-N-glycolyl-ganglioside and its anti-idiotypic MAbs: immunodominance of their variable regions. PMID: 14511569
Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody. PMID: 21306777
Gangliosides, Ab1 and Ab2 antibodies I. Towards a molecular dissection of an idiotype-anti-idiotype system. PMID: 16581129
Anti-GM3-lactam monoclonal antibodies of the IgG type recognize natural GM3-ganglioside lactone but not GM3-ganglioside. PMID: 1305422
Syngeneic anti-idiotypic monoclonal antibodies to an anti-NeuGc-containing ganglioside monoclonal antibody. PMID: 9890708
Insights into the immunogenetic basis of two ganglioside-associated idiotypic networks. PMID: 17270710
Generation of anti-Neu-glycolyl-ganglioside antibodies by immunization with an anti-idiotype monoclonal antibody: A self versus non-self-matter. PMID: 16076030
Delineation of the epitope recognized by an antibody specific for N-glycolylneuraminic acid-containing gangliosides. PMID: 9621110
Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody PMID: 19748674
For research use only. Not for human or drug use.
