Catalog No.
FHG71210
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14126
Applications
Blocking, ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
3D3
Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy., PMID:39763850
Prevalence and Correlates of Anti-DSG2 Antibodies in Arrhythmogenic Right Ventricular Cardiomyopathy and Myocarditis: Immunological Insights from a Multicenter Study., PMID:39597880
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus., PMID:38677661
Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion., PMID:37450050
IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism., PMID:37401875
SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection., PMID:37095599
Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade., PMID:36268721
Properties of Adenovirus Vectors with Increased Affinity to DSG2 and the Potential Benefits of Oncolytic Approaches and Gene Therapy., PMID:36016457
Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris., PMID:35844545
High frequency of anti-DSG 2 antibodies in post COVID-19 serum samples., PMID:35764120
Translational development of a tumor junction opening technology., PMID:35562182
TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways., PMID:35392784
A Novel Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Biomarker-Anti-DSG2-Is Absent in Athletes With Right Ventricular Enlargement., PMID:34993452
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection., PMID:34910784
Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion., PMID:34168237
Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer., PMID:33431674
DSG2 expression is low in colon cancer and correlates with poor survival., PMID:33407183
Dsg2 Upregulation as a Rescue Mechanism in Pemphigus., PMID:33193387
Selective elimination of human pluripotent stem cells by Anti-Dsg2 antibody-doxorubicin conjugates., PMID:32827795
Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles., PMID:32581096
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy., PMID:32529556
A Targeted Mass Spectrometry Strategy for Developing Proteomic Biomarkers: A Case Study of Epithelial Ovarian Cancer., PMID:31289117
Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion., PMID:31178865
KC21 Peptide Inhibits Angiogenesis and Attenuates Hypoxia-Induced Retinopathy., PMID:30790141
Broadly neutralizing monoclonal antibodies against human adenovirus types 55, 14p, 7, and 11 generated with recombinant type 11 fiber knob., PMID:30531794
An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis., PMID:30239670
DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells., PMID:29910125
Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion., PMID:29753032
Junction opener protein increases nanoparticle accumulation in solid tumors., PMID:29305923
Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy., PMID:28764973
Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase., PMID:28740231
Adherens junctions and desmosomes are damaged by Entamoeba histolytica: Participation of EhCPADH complex and EhCP112 protease., PMID:28656597
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion., PMID:28289018
Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy., PMID:28183531
Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells., PMID:28154962
Human Adenovirus Serotype 3 Vector Packaged by a Rare Serotype 14 Hexon., PMID:27328032
The CpAL system regulates changes of the trans-epithelial resistance of human enterocytes during Clostridium perfringens type C infection., PMID:27063897
Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages., PMID:26294113
Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1., PMID:26168049
Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin., PMID:26029716
Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus., PMID:24776707
Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts., PMID:24086444
Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus., PMID:23489520
Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion., PMID:23326495
Overcoming physical barriers in cancer therapy., PMID:24665377
IgG autoantibody response against keratinocyte cadherins in endemic pemphigus foliaceus (fogo selvagem)., PMID:22810308
Coadministration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs., PMID:22535153
Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display., PMID:22277944
Epitope spreading is rarely found in pemphigus vulgaris by large-scale longitudinal study using desmoglein 2-based swapped molecules., PMID:22277941
Five Japanese cases of antidesmoglein 1 antibody-positive and antidesmoglein 3 antibody-negative pemphigus with oral lesions., PMID:22242828
For research use only. Not for human or drug use.
