Anti-TMPRSS2 Polyclonal Antibody

Catalog No.

PHA51501

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TMPRSS2 (Ser284-Gly492).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Serine protease 10,PRSS10,TMPRSS2,Transmembrane protease serine 2

Purification

Purified by antigen affinity column.

Accession

O15393

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission., PMID:40475451

Immune evasion, infectivity, and membrane fusion of the SARS-CoV-2 JN.1 variant., PMID:40413500

The underlying mechanism behind the different outcomes of COVID-19 in children and adults., PMID:40370452

Advances in COVID-19 Therapeutics: Exploring the role of lectins and protease inhibitors., PMID:40349995

Entry Efficiency, Protease Dependence, and Antibody-Mediated Neutralization of SARS-CoV-2 Sublineages KP.3.1.1 and XEC., PMID:40333265

Structural insights into the receptor-binding domain of bat coronavirus ZXC21., PMID:40306273

Lower Expression of SARS-CoV-2 Host Cell Entry Genes in the Intestinal Mucosa of IBD Patients With Quiescent or Mildly Active Disease., PMID:40279370

Capture of fusion-intermediate conformations of SARS-CoV-2 spike requires receptor binding and cleavage at either the S1/S2 or S2' site., PMID:40198676

A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity., PMID:40020261

Transmembrane protease serine 2 (TMPRSS2) inhibitors screened from an Fv-antibody library for preventing SARS-CoV-2 infection., PMID:39990164

Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus HKU1 in Southern France With Emergence of Viruses Harboring Spike H512R Substitution., PMID:39949218

Cross-sectional and longitudinal genotype to phenotype surveillance of SARS-CoV-2 variants over the first four years of the COVID-19 pandemic., PMID:39549677

ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization., PMID:39536058

Improved efficacy of SARS-CoV-2 isolation from COVID-19 clinical specimens using VeroE6 cells overexpressing TMPRSS2 and human ACE2., PMID:39438626

Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in mice., PMID:39353281

Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site., PMID:39290379

SARS-CoV-2 infectivity and antigenic evasion: spotlight on isolated Omicron sub-lineages., PMID:39267969

Mechanistic insights into bismuth(iii) inhibition of SARS-CoV-2 helicase., PMID:38966375

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor., PMID:38964328

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus., PMID:38964326

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants., PMID:38791489

Combination of spironolactone and DPP-4 inhibitors for treatment of SARS-CoV-2 infection: a literature review., PMID:38753071

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning., PMID:38744813

Characterizing fitness and immune escape of SARS-CoV-2 EG.5 sublineage using elderly serum and nasal organoid., PMID:38660398

A novel approach to designing viral precision vaccines applied to SARS-CoV-2., PMID:38628551

Lipid Nanoparticle-Based Inhibitors for SARS-CoV-2 Host Cell Infection., PMID:38562613

Establishment of replication-competent vesicular stomatitis virus recapitulating SADS-CoV entry., PMID:38557247

Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals., PMID:38548023

Quantitative and Standardized Pseudovirus Neutralization Assay for COVID-19., PMID:38526789

Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry., PMID:38501663

Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2., PMID:38396898

Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes., PMID:38307396

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor., PMID:38260518

SARS-CoV-2 BA.2.86 enters lung cells and evades neutralizing antibodies with high efficiency., PMID:38194966

Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2+ Cells., PMID:38194699

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning., PMID:38076875

Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant., PMID:38057313

Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening., PMID:38033116

Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization., PMID:38026181

Viral Entry Inhibitors Protect against SARS-CoV-2-Induced Neurite Shortening in Differentiated SH-SY5Y Cells., PMID:37896797

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues., PMID:37892063

TMPRSS2 is a functional receptor for human coronavirus HKU1., PMID:37879362

Removal of Soluble ACE2 in VeroE6 Cells by 17β-Estradiol Reduces SARS-CoV-2 Infectivity., PMID:37866890

Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses., PMID:37794073

Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies., PMID:37632039

PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding., PMID:37562608

SARS-CoV-2 Spike Protein Is Capable of Inducing Cell-Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin Inhibitors or a Subset of Monoclonal Antibodies., PMID:37515187

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors., PMID:37503261

Verifying AXL and putative proteins as SARS-CoV-2 receptors by DnaE intein-based rapid cell-cell fusion assay., PMID:37461287

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection., PMID:37438530

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