Catalog No.
YHC02501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr2-Ser183
Predicted molecular weight
22.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P02794
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FTH, FTH1, FTHL6, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, Ferritin heavy chain
Nrf2 Alleviates Colistin-Induced Nephrotoxicity by Suppressing Ferroptosis via GPX4-Mediated Lipid Peroxidation and Mitochondrial Protection., PMID:40474460
[Fucoidan sulfate regulates Hmox1-mediated ferroptosis to ameliorate myocardial injury in diabetic cardiomyopathy]., PMID:40461202
Discovery of novel genipin derivatives as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer., PMID:40446585
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy., PMID:40441459
Immunohistochemical Detection of Iron-Related Proteins in Sertoli Cell-Only Patterns in Canine Testicular Lesions., PMID:40427255
Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression., PMID:40416363
Ferroptosis effects and behavioral changes associated with high accumulation and low elimination percentage of silver in brain following a 28-day nasal instillation of silver nanoparticles in mice., PMID:40409664
Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells., PMID:40406482
Therapeutic time window of sodium of Danshensu on cerebral ischemia and its mechanism of inhibiting oxidative stress and ferroptosis through Nrf2 pathway., PMID:40403934
The mechanism of electroacupuncture-mediated improvement in Parkinson's disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway., PMID:40400910
ATF4 participates in perfluorooctane sulfonate-induced neurotoxicity by regulating ferroptosis., PMID:40393319
Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth., PMID:40384984
WTAP targets SOX2 to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia via m6A-dependent ferroptosis regulation., PMID:40383175
IGFBP7: A novel biomarker involved in a positive feedback loop with TGF-β1 in idiopathic pulmonary fibrosis., PMID:40381971
A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics., PMID:40381315
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs., PMID:40369118
The NFE2L2 (NRF2) transcription factor controls genes involved in the oxidative stress response and inflammation in myometrial cells., PMID:40360022
Aerobic exercise alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis., PMID:40349681
NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis., PMID:40349344
SARS-CoV-2 N protein interacts with SLC7A11 to cause ferroptosis in acute lung injury., PMID:40342111
Assessing the potential for in vivo modulation of FTH1 gene expression with small peptides to restore and enhance androgen receptor pathway inhibition in prostate cancer., PMID:40340699
SFTSV induces liver ferroptosis through m6A-related ferritinophagy., PMID:40340535
FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis., PMID:40334546
CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis., PMID:40331957
Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis., PMID:40327971
Tetrandrine Improves Severe Acute Pancreatitis by Inhibiting NCOA4 Glycosylation-Mediated Binding to FTH1 and Inducing Autophagy-Dependent Ferroptosis., PMID:40326888
Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis., PMID:40319933
Transcription factor BACH1 promotes epithelial-mesenchymal transition by repressing iron metabolism-related genes., PMID:40315568
Mechanistic insights into cadmium-induced nephrotoxicity: NRF2-Driven HO-1 activation promotes ferroptosis via iron overload and oxidative stress in vitro., PMID:40311785
Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia., PMID:40309008
Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies., PMID:40308274
Vertebral Osteoporosis in Systemic Lupus Erythematosus: A Possible Involvement of Inflammation-Related Osteoblast Ferroptosis., PMID:40303004
[Catalpol reduces liver toxicity of triptolide in mice by inhibiting hepatocyte ferroptosis through the SLC7A11/GPX4 pathway: testing the Fuzheng Zhidu theory for detoxification]., PMID:40294931
Euphorbia humifusa Willd. ex Schltdl. Mitigates Liver Injury via KEAP1-NFE2L2-Mediated Ferroptosis Regulation: Network Pharmacology and Experimental Validation., PMID:40284852
Mouse hindlimb unloading, as a model of simulated microgravity, leads to dysregulated iron homeostasis in liver and skeletal muscle cells., PMID:40280644
4, 9-dihydroxy-α-lapachone as a potent antiproliferation agent for triple-negative breast cancer via ferroptosis., PMID:40280251
9-Hexadecenoic acid inhibits the aggressiveness of gastric cancer via targeting PTPN1/FTH1 signaling., PMID:40279138
Prepubertal Exposure to Tris(2-chloroethyl) Phosphate Disrupts Blood-Testis Barrier Integrity via Ferritinophagy-Mediated Ferroptosis., PMID:40278601
Transcription factor FOS promotes ferroptosis and inflammation in S. aureus- infected osteomyelitis via EIF5A., PMID:40270004
Electroacupuncture Ameliorates Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Nrf2-Mediated Ferroptosis in Hippocampal Neurons., PMID:40257585
Alkbh5 promotes Ythdf1 expression through demethylation thereby facilitating Fth1 translation to inhibit ferroptosis of myocardial infarction., PMID:40251485
APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion., PMID:40245754
Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway., PMID:40215776
Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway., PMID:40206070
[G protein-coupled estrogen receptor alleviates lung injury in mice with exertional heat stroke by inhibiting ferroptosis]., PMID:40201998
Ferritinophagy: a possible new iron-related metabolic target in canine osteoblastic osteosarcoma., PMID:40196812
MiR214-3p Ameliorates Diabetic Cardiomyopathy by Inhibiting Ferroptosis., PMID:40193015
Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro., PMID:40191047
Investigation of Ferroptosis Mechanisms in Ischemic Stroke Treated with Electroacupuncture: Focusing on the NCOA4-FTH1 Signaling Pathway., PMID:40189641
ETS1 modulates ferroptosis to affect the process of myocardial ischemia-reperfusion injury via PIM3., PMID:40189183
For research use only. Not for human or drug use.
