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Research Grade Tezepelumab (DHJ36101)

Host species:Human
Isotype:IgG2-lambda
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHJ36101

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2-lambda

Clonality

Monoclonal

Target

TSLP, Thymic stromal lymphopoietin

Concentration

3.2 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q969D9

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG 157, AMG-157, MEDI-9929, MEDI9929, anti-TSLP-Receptor (TSLP-R, Crl2), CAS: 1572943-04-4

Clone ID

Tezepelumab

Data Image
  • SDS-PAGE
    SDS PAGE for Tezepelumab
  • Bioactivity
    Detects TSLP in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

[Alarmins and anti-alarmin biologics in asthma], PMID: 30246661

A Phase 1, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Subcutaneous Tezepelumab in Healthy Japanese Men, PMID: 31960624

Antibodies to watch in 2021, PMID: 33459118

Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses, PMID: 31974038

Biological therapies for atopic dermatitis: An update, PMID: 30679974

Biologics for the Treatments of Allergic Conditions: Severe Asthma, PMID: 33012319

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma, PMID: 33050900

DESTINATION: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe, uncontrolled asthma, PMID: 33087119

Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial, PMID: 34256031

Efficacy of biologics in atopic dermatitis, PMID: 32003247

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma and Perennial Allergy, PMID: 34358701

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with and without Nasal Polyposis: A Post Hoc Analysis of the Phase 2b PATHWAY Study, PMID: 33568920

Emerging Treatment Options in Atopic Dermatitis: Systemic Therapies, PMID: 29320765

Functionality and Performance of an Accessorized Pre-Filled Syringe and an Autoinjector for At-Home Administration of Tezepelumab in Patients with Severe, Uncontrolled Asthma, PMID: 33907423

Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria, PMID: 31690400

Molecular Targets for Biological Therapies of Severe Asthma: Focus on Benralizumab and Tezepelumab, PMID: 34440488

Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis, PMID: 31395084

NAVIGATOR: a phase 3 multicentre, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of tezepelumab in adults and adolescents with severe, uncontrolled asthma, PMID: 33050934

New Anti-Eosinophil Drugs for Asthma and COPD: Targeting the Trait!, PMID: 28583618

New perspectives of childhood asthma treatment with biologics, PMID: 30444939

New Targeted Therapies for Uncontrolled Asthma, PMID: 31076057

Novel Therapeutic Approaches and Targets for the Treatment of Atopic Dermatitis, PMID: 32525769

Pharmacokinetic and Pharmacodynamic Modeling of Tezepelumab to Guide Phase 3 Dose Selection for Patients With Severe Asthma, PMID: 33368307

Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects, PMID: 30779339

Review and analysis of biologic therapies currently in phase II and phase III clinical trials for atopic dermatitis, PMID: 32507066

Revisiting Therapies for Atopic Dermatitis that Failed Clinical Trials, PMID: 32172523

Severe asthma: what is new in the new millennium, PMID: 32004177

SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma, PMID: 33050928

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma, PMID: 28368013

Targeted Molecular Therapies in Allergy and Rhinology, PMID: 33138725

T-cell inhibitors for atopic dermatitis, PMID: 29248519

Tezepelumab as an Emerging Therapeutic Option for the Treatment of Severe Asthma: Evidence to Date, PMID: 33536746

Tezepelumab improves patient-reported outcomes in patients with severe, uncontrolled asthma in PATHWAY, PMID: 33169672

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma, PMID: 33979488

Tezepelumab in Adults with Uncontrolled Asthma, PMID: 28877011

Tezepelumab in Adults with Uncontrolled Asthma, PMID: 31034183

Tezepelumab normalizes serum interleukin-5 and -13 levels in patients with severe, uncontrolled asthma, PMID: 34403803

Tezepelumab Pharmacokinetics, Safety, and Tolerability After Administration via Vial-and-syringe, Accessorized Prefilled Syringe, or Autoinjector: A Randomized Trial in Healthy Volunteers, PMID: 33380362

Tezepelumab prepares to enter the asthma antibody fray, PMID: 33441998

Tezepelumab Reduces Exacerbations Across All Seasons in Patients with Severe, Uncontrolled Asthma: A Post Hoc Analysis of the PATHWAY Phase 2b Study, PMID: 33469316

Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial, PMID: 30550828

Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma, PMID: 31549891

Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma, PMID: 33922072

The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM), PMID: 34049943

The effect of tezepelumab on hospitalizations and emergency department visits in patients with severe asthma, PMID: 32474159

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer, PMID: 30057581

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma, PMID: 32567399

TSLP Inhibitors for Asthma: Current Status and Future Prospects, PMID: 32078149

Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option?, PMID: 33059715

What's New in Atopic Dermatitis, PMID: 30850043

Datasheet

Document Download

Research Grade Tezepelumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Tezepelumab [DHJ36101]
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