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Research Grade Anti-Influenza A virus HA/Hemagglutinin Broad-Neutralizing Antibody (CR9114)

Catalog #:   DVV03807 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DVV03807

Expression system

Mammalian Cells

Species reactivity

Influenza A virus (A/Brisbane/59/2007(H1N1)), Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Influenza A virus (strain A/Hong Kong/1/1968 H3N2), Influenza A virus (A/Netherlands/219/2003(H7N7))

Host species

Human

Isotype

IgG1

Clonality

Monoclonal

Target

HA, Hemagglutinin

Concentration

0.94 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

D5F1Q8, Q6DQ33, Q91MA7, Q6VMK1

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

CR9114

Data Image
References

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface., PMID:40391889

An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses., PMID:40301359

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies., PMID:40267182

A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses., PMID:40193611

Identification and characterization of a broadly neutralizing and protective nanobody against the HA1 domain of H5 avian influenza virus hemagglutinin., PMID:40192291

Cross-Reactive Fc-Mediated Antibody Responses to Influenza HA Stem Region in Human Sera Following Seasonal Vaccination., PMID:40006687

Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes., PMID:39894881

Computational design and improvement of a broad influenza virus HA stem targeting antibody., PMID:39884272

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection., PMID:39788944

Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem., PMID:39580804

A Broad Influenza Vaccine Based on a Heat-Activated, Tissue-Restricted Replication-Competent Herpesvirus., PMID:39066341

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase., PMID:38899870

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus., PMID:38782954

Preparation and characterization of mouse-derived monoclonal antibodies against the hemagglutinin of the H1N1 influenza virus., PMID:38772446

Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses., PMID:38670113

Influenza antibody breadth and effector functions are immune correlates from acquisition of pandemic infection of children., PMID:38615070

mRNA vaccines encoding computationally optimized hemagglutinin elicit protective antibodies against future antigenically drifted H1N1 and H3N2 influenza viruses isolated between 2018-2020., PMID:38533508

Antigenic commonality and divergence of hemagglutinin-esterase-fusion protein among influenza D virus lineages revealed using epitope mapping., PMID:38345383

Combinatorial immune refocusing within the influenza hemagglutinin RBD improves cross-neutralizing antibody responses., PMID:38096052

Sequential vaccinations with divergent H1N1 influenza virus strains induce multi-H1 clade neutralizing antibodies in swine., PMID:38008801

Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody., PMID:37515226

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD., PMID:37394992

Highly Cross-Reactive and Protective Influenza A Virus H3N2 Hemagglutinin- and Neuraminidase-Specific Human Monoclonal Antibodies., PMID:37318331

Neutralizing and protective murine monoclonal antibodies to the hemagglutinin of influenza H5 clades 2.3.2.1 and 2.3.4.4., PMID:37246149

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine., PMID:37185989

Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies., PMID:37068231

Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence., PMID:37067355

Development of a broadly active influenza intranasal vaccine adjuvanted with self-assembled particles composed of mastoparan-7 and CpG., PMID:37033992

Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice., PMID:37003306

Analysis of the conserved protective epitopes of hemagglutinin on influenza A viruses., PMID:36875062

Multi-Influenza HA Subtype Protection of Ferrets Vaccinated with an N1 COBRA-Based Neuraminidase., PMID:36680224

Identification of Unique and Conserved Neutralizing Epitopes of Vestigial Esterase Domain in HA Protein of the H9N2 Subtype of Avian Influenza Virus., PMID:36560743

Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses., PMID:36517323

Reverse genetics based H5N2 vaccine provides clinical protection against H5N1, H5N8 and H9N2 avian influenza infection in chickens., PMID:36374710

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses., PMID:36356572

A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases., PMID:36329075

Heterosubtypic immune pressure accelerates emergence of influenza A virus escape phenotypes in mice., PMID:36302472

Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses., PMID:36056024

Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication., PMID:36037479

Novel H7N9 influenza immunogen design enhances mobilization of seasonal influenza T cell memory in H3N2 pre-immune mice., PMID:35704783

Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates., PMID:35680500

A broadly neutralizing human monoclonal antibody against the hemagglutinin of avian influenza virus H7N9., PMID:35671181

Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus., PMID:35501328

Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite., PMID:35489332

Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs., PMID:35458460

Supplementation of H7N9 Virus-Like Particle Vaccine With Recombinant Epitope Antigen Confers Full Protection Against Antigenically Divergent H7N9 Virus in Chickens., PMID:35265069

[Characterization of a monoclonal antibody against the hemagglutinin stem of H7N9 subtype avian influenza virus]., PMID:35142127

A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination., PMID:35115707

Vaccine-Associated Enhanced Respiratory Disease following Influenza Virus Infection in Ferrets Recapitulates the Model in Pigs., PMID:34985999

A Host-Restricted Self-Attenuated Influenza Virus Provides Broad Pan-Influenza A Protection in a Mouse Model., PMID:34925355

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

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For research use only. Not for human or drug use.

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Research Grade Anti-Influenza A virus HA/Hemagglutinin Broad-Neutralizing Antibody (CR9114) [DVV03807]
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