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Anti-Human TYRP1 Antibody (TA99)

Catalog #:   RHD25201 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: IF, WB
Accession: P17643
Overview

Catalog No.

RHD25201

Species reactivity

Human, Mouse, Rat

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

5,6-dihydroxyindole-2-carboxylic acid oxidase, Glycoprotein 75, CAS2, TYRP1, TRP-1, TYRRP, TRP1, Catalase B, TYRP, Melanoma antigen gp75, TRP, DHICA oxidase, Tyrosinase-related protein 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P17643

Applications

IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

TA99

Data Image
References

TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models., PMID:39308793

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure., PMID:38577337

Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG., PMID:37593202

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma., PMID:37208128

Evaluating the Application Potential of a Recombinant Ganoderma Protein as Bioactive Ingredients in Cosmetics., PMID:37050035

Preclinical InVivo Data Integrated in a Modeling Network Informs a Refined Clinical Strategy for a CD3 T-Cell Bispecific in Combination with Anti-PD-L1., PMID:36207642

GIF-2209, an Oxindole Derivative, Accelerates Melanogenesis and Melanosome Secretion via the Modification of Lysosomes in B16F10 Mouse Melanoma Cells., PMID:35011407

Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo., PMID:34854998

Comparison of tyrosinase antibody, tyrosinase-related protein-1 and -2 antibodies, melanin-concentrating hormone receptor antibody levels with autologous serum skin test and autologous plasma skin test results in patients with vitiligo., PMID:34377130

Characterization of Immune Infiltration and Construction of a Prediction Model for Overall Survival in Melanoma Patients., PMID:33869027

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma., PMID:33520112

Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice., PMID:33084421

Therapeutic efficacy of PD1/PDL1 blockade in B16 melanoma is greatly enhanced by immunization with dendritic cell-targeting lentiviral vector and protein vaccine., PMID:32088020

Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients., PMID:30786924

Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin., PMID:30543899

High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy., PMID:30397036

Antigen-specificity of antiretinal antibodies in patients with noninfectious uveitis., PMID:28985805

Spontaneous generation of a novel foetal human retinal pigment epithelium (RPE) cell line available for investigation on phagocytosis and morphogenesis., PMID:28924976

An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma., PMID:27797971

CRISPR/Cas9 Targets Chicken Embryonic Somatic Cells In Vitro and In Vivo and generates Phenotypic Abnormalities., PMID:27694906

Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection., PMID:27193292

A large insertion in intron 2 of the TYRP1 gene associated with American Palomino phenotype in American mink., PMID:26886941

An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen., PMID:25875653

Hyperosmotic stress reduces melanin production by altering melanosome formation., PMID:25170965

Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology., PMID:24880201

Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice., PMID:24613852

Aire deficiency promotes TRP-1-specific immune rejection of melanoma., PMID:23370329

Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma., PMID:21324755

GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1., PMID:20668223

Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice., PMID:19414747

Immune rejection of mouse tumors expressing mutated self., PMID:19351857

The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas., PMID:19287070

CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection., PMID:19276379

Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma., PMID:19047169

Enhanced suppression of melanoma tumor growth and metastasis by combined therapy with anti-VEGF receptor and anti-TYRP-1/gp75 monoclonal antibodies., PMID:19035294

Generation and characterization of a therapeutic human antibody to melanoma antigen TYRP1., PMID:18334748

RHEB expression in fibroadenomas of the breast., PMID:18324915

Tumor endothelial marker 8 enhances tumor immunity in conjunction with immunization against differentiation Ag., PMID:18236207

Dependency of intraocular pressure elevation and glaucomatous changes in DBA/2J and DBA/2J-Rj mice., PMID:18235006

Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage., PMID:18055784

The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers., PMID:16682408

Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes., PMID:16040064

Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment., PMID:15096515

Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1., PMID:14623273

Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination: unexpected reactivity to a protein paralogue., PMID:12747753

Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo., PMID:12121667

The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase., PMID:12028586

Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase., PMID:11775059

The role of phosphoinositide 3-kinase in the sorting and transport of newly synthesized tyrosinase-related protein-1 (TRP-1)., PMID:11764278

Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA., PMID:11564171

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-Human TYRP1 Antibody (TA99) [RHD25201]
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