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Anti-TNFRSF11B Polyclonal Antibody

Catalog #:   PHA08601 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: O00300
Overview

Catalog No.

PHA08601

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TNFRSF11B (Thr76-Lys317).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,OCIF

Purification

Purified by antigen affinity column.

Accession

O00300

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with TNFRSF11B antibody (PHA08601) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 30 kDa
    Observed MW: 30 kDa
References

Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease., PMID:40223037

Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?, PMID:39684440

Genetic Variants in RANK and OPG Could Influence Disease Severity and Bone Remodeling in Patients with Early Arthritis., PMID:39337893

Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease., PMID:38443806

Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage., PMID:38097649

Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment., PMID:36189226

Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis., PMID:35680906

The Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulins., PMID:35502340

Rhizomelia and Impaired Linear Growth in a Girl with Juvenile Paget Disease: The Natural History of the Condition., PMID:34261073

RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp., PMID:33633362

Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174

Iron Overload-Induced Osteocyte Apoptosis Stimulates Osteoclast Differentiation Through Increasing Osteocytic RANKL Production In Vitro., PMID:32995951

Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice., PMID:32854340

TNF Receptor: Fc Fusion Protein Downregulates RANKL/OPG Ratio by Inhibiting CXCL16/CXCR6 in Active Ankylosing Spondylitis., PMID:32116188

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity., PMID:31932605

Beneficial effects of anti-RANKL antibody in depression-like phenotype, inflammatory bone markers, and bone mineral density in male susceptible mice after chronic social defeat stress., PMID:31790783

Increased frequency of regulatory T cells in pediatric inflammatory bowel disease at diagnosis: a compensative role?, PMID:31715619

Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration., PMID:31425530

Correlation between Osteoprotegerin Levels and Antiphospholipid Syndrome Parameters., PMID:31414130

Combination of G-CSF and AMD3100 Improves the Anti-inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages Through NF-κB-IL1RA Signaling Pathway., PMID:31191315

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass., PMID:31120440

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration., PMID:31101043

The induction of RANKL molecule clustering could stimulate early osteoblast differentiation., PMID:30594398

Regulation of osteoblast differentiation by osteocytes cultured on sclerostin antibody conjugated TiO2 nanotube array., PMID:30590327

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden., PMID:30496606

Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke., PMID:30496210

Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies., PMID:30460589

Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer., PMID:30425091

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy., PMID:29699580

The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats., PMID:29649498

Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function., PMID:28854965

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy., PMID:28580511

Low-level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical-size defects and increases TGF-β, FGF-2, OPG/RANK and osteocalcin expression., PMID:28556971

Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts., PMID:28543818

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study., PMID:28534161

Denosumab for the treatment of adult multisystem Langerhans cell histiocytosis., PMID:28285639

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis., PMID:27621061

Interleukin-4 released from human gingival fibroblasts reduces osteoclastogenesis., PMID:27608363

[Effect of tumour necrosis factor α blockade on bone metabolism in chronic inflammatory joint diseases]., PMID:27209224

Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer., PMID:27145458

[Value of serum osteoprotegerin in noninvasive diagnosis of nonalcoholic steatohepatitis]., PMID:26983475

Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand., PMID:26894505

Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-α., PMID:26856585

RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion., PMID:26398902

Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy., PMID:26364678

Osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as prognostic factors in rheumatoid arthritis: results from the ESPOIR cohort., PMID:26220665

Characterisation of osteoprotegerin autoantibodies in coeliac disease., PMID:26092508

Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion., PMID:25978399

Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts., PMID:25956608

[Correlation of RANKL/OPG, dickkopf-1 and bone marrow edema in rheumatoid arthritis with the complaint of knee pain]., PMID:25924445

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-TNFRSF11B Polyclonal Antibody [PHA08601]
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