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Anti-TNFRSF11B Polyclonal Antibody

Catalog #:   PHA08601 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: O00300
Overview

Catalog No.

PHA08601

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TNFRSF11B (Thr76-Lys317).

Applications

ELISA, IHC, WB

Recommended Dilution

Application Dilution
ELISA 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,OCIF

Purification

Purified by antigen affinity column.

Accession

O00300

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Note

For research use only.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with TNFRSF11B antibody (PHA08601) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 30 kDa
    Observed MW: 30 kDa
References

[Correlation of RANKL/OPG, dickkopf-1 and bone marrow edema in rheumatoid arthritis with the complaint of knee pain]., PMID:25924445

Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts., PMID:25956608

Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion., PMID:25978399

Characterisation of osteoprotegerin autoantibodies in coeliac disease., PMID:26092508

Osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as prognostic factors in rheumatoid arthritis: results from the ESPOIR cohort., PMID:26220665

Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy., PMID:26364678

RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion., PMID:26398902

Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-α., PMID:26856585

Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand., PMID:26894505

[Value of serum osteoprotegerin in noninvasive diagnosis of nonalcoholic steatohepatitis]., PMID:26983475

Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer., PMID:27145458

[Effect of tumour necrosis factor α blockade on bone metabolism in chronic inflammatory joint diseases]., PMID:27209224

Interleukin-4 released from human gingival fibroblasts reduces osteoclastogenesis., PMID:27608363

β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis., PMID:27621061

Denosumab for the treatment of adult multisystem Langerhans cell histiocytosis., PMID:28285639

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study., PMID:28534161

Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts., PMID:28543818

Low-level laser therapy (780 nm) combined with collagen sponge scaffold promotes repair of rat cranial critical-size defects and increases TGF-β, FGF-2, OPG/RANK and osteocalcin expression., PMID:28556971

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy., PMID:28580511

Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function., PMID:28854965

The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats., PMID:29649498

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy., PMID:29699580

Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer., PMID:30425091

Dynamics of Bone Cell Interactions and Differential Responses to PTH and Antibody-Based Therapies., PMID:30460589

Alterations in bone turnover markers in patients with noncardio-embolic ischemic stroke., PMID:30496210

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden., PMID:30496606

Regulation of osteoblast differentiation by osteocytes cultured on sclerostin antibody conjugated TiO2 nanotube array., PMID:30590327

The induction of RANKL molecule clustering could stimulate early osteoblast differentiation., PMID:30594398

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration., PMID:31101043

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass., PMID:31120440

Combination of G-CSF and AMD3100 Improves the Anti-inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages Through NF-κB-IL1RA Signaling Pathway., PMID:31191315

Correlation between Osteoprotegerin Levels and Antiphospholipid Syndrome Parameters., PMID:31414130

Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration., PMID:31425530

Increased frequency of regulatory T cells in pediatric inflammatory bowel disease at diagnosis: a compensative role?, PMID:31715619

Beneficial effects of anti-RANKL antibody in depression-like phenotype, inflammatory bone markers, and bone mineral density in male susceptible mice after chronic social defeat stress., PMID:31790783

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity., PMID:31932605

TNF Receptor: Fc Fusion Protein Downregulates RANKL/OPG Ratio by Inhibiting CXCL16/CXCR6 in Active Ankylosing Spondylitis., PMID:32116188

Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice., PMID:32854340

Iron Overload-Induced Osteocyte Apoptosis Stimulates Osteoclast Differentiation Through Increasing Osteocytic RANKL Production In Vitro., PMID:32995951

Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174

RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp., PMID:33633362

Rhizomelia and Impaired Linear Growth in a Girl with Juvenile Paget Disease: The Natural History of the Condition., PMID:34261073

The Effect of Flowable Composite Resins on Periodontal Health, Cytokine Levels, and Immunoglobulins., PMID:35502340

Osteoprotegerin and MTHFR gene variations in rheumatoid arthritis: association with disease susceptibility and markers of subclinical atherosclerosis., PMID:35680906

Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment., PMID:36189226

Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage., PMID:38097649

Osteopontin, osteoprotegerin and musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis: potential markers of preclinical disease., PMID:38443806

Genetic Variants in RANK and OPG Could Influence Disease Severity and Bone Remodeling in Patients with Early Arthritis., PMID:39337893

Are the Soluble Receptors sRAGE, sRANKL, and Osteoprotegerin Associated with Anemia in Rheumatoid Arthritis?, PMID:39684440

Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease., PMID:40223037

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-TNFRSF11B Polyclonal Antibody [PHA08601]
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