Catalog No.
PHA03501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SNAP23 (Met1-Ser211).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Synaptosomal-associated protein 23,SNAP-23,Vesicle-membrane fusion protein SNAP-23,SNAP23
Purification
Purified by antigen affinity column.
Accession
O00161
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME., PMID:39491031
Annexin A6 modulates the secretion of pro-inflammatory cytokines and exosomes via interaction with SNAP23 in triple negative breast cancer cells., PMID:39484394
Generation and Characterization of a TRIM21 Overexpressing Mouse Line., PMID:39487578
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation., PMID:38563147
Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B+ vesicle pathway in liver cancer., PMID:36044553
Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells., PMID:35579416
VAMPs sensitive to tetanus toxin are required for cortical granule exocytosis in mouse oocytes., PMID:34023392
Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties., PMID:30036609
Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages., PMID:29771640
Proximity Ligation Assay to Study the GLUT4 Membrane Trafficking Machinery., PMID:29218528
Crossreactivity of an Antiserum Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae with the SNARE-Complex Protein Snap23 Correlates to Impaired Exocytosis in SH-SY5Y Cells., PMID:28462458
Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases., PMID:27694038
Different activation signals induce distinct mast cell degranulation strategies., PMID:27643442
VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins., PMID:27616736
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria., PMID:26733245
Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells., PMID:26099315
IκB kinase 2 is essential for IgE-induced mast cell de novo cytokine production but not for degranulation., PMID:25176657
Calpain-1 contributes to IgE-mediated mast cell activation., PMID:24760147
SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line., PMID:24373201
Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells., PMID:24146186
Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC., PMID:22713544
The suppression of IgE-mediated histamine release from mast cells following exocytic exclusion of biodegradable polymeric nanoparticles., PMID:21993238
SNAP-23 and syntaxin-3 are required for chemokine release by mature human mast cells., PMID:21981832
Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress., PMID:21768361
Glucose-dependent changes in SNARE protein levels in pancreatic β-cells., PMID:21285315
Differential expression of SNAP-25 family proteins in the mouse brain., PMID:21280044
PKC-dependent inhibition of CA2+-dependent exocytosis from astrocytes., PMID:20967886
SNARE-mediated membrane traffic is required for focal adhesion kinase signaling and Src-regulated focal adhesion turnover., PMID:20888376
Engineering botulinum neurotoxin to extend therapeutic intervention., PMID:19487672
Allergen-sensitization increases mast-cell expression of the exocytotic proteins SNAP-23 and syntaxin 4, which are involved in histamine secretion., PMID:18973100
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4., PMID:18713833
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation., PMID:18692471
Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue., PMID:18457912
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells., PMID:18253931
VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways., PMID:18203950
Thiosulfinates modulate platelet activation by reaction with surface free sulfhydryls and internal thiol-containing proteins., PMID:17852771
Physical and functional interactions of SNAP-23 with annexin A2., PMID:17575076
Identification of SNAREs that mediate zymogen granule exocytosis., PMID:17544372
Dysfunction of Golgi tethers, SNAREs, and SNAPs in monocrotaline-induced pulmonary hypertension., PMID:17337506
Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis., PMID:16984405
A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils., PMID:16677249
Effect of cholesterol depletion on exocytosis of alveolar type II cells., PMID:16439800
Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate., PMID:16405496
Identification of soluble N-ethylmaleimide-sensitive factor attachment protein receptor exocytotic machinery in human plasma cells: SNAP-23 is essential for antibody secretion., PMID:16272324
Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)., PMID:15102850
Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion., PMID:15035620
Roles of Munc18-3 in amylase release from rat parotid acinar cells., PMID:14759605
CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex., PMID:12209004
Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells., PMID:12186952
Subcellular distribution of 3 functional platelet SNARE proteins: human cellubrevin, SNAP-23, and syntaxin 2., PMID:12010801
For research use only. Not for human or drug use.
