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Ocaratuzumab ELISA Kit

Catalog #:   KDC90707 Specific References (50) DATASHEET
Sample type: Plasma, Serum
Sensitivity: 0.156 μg/ml
Range: 0.31-5 μg/mL
Overview

Catalog No.

KDC90707

Detection method

Colorimetric

Sample type

Plasma, Serum

Assay type

Quantitative

Range

0.31-5 μg/mL

Sensitivity

0.156 μg/ml

Precision

CV<20%

Recovery

80-120%

Shipping

2-8 ℃

Stability and Storage

The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.

Alternative Names

AME-133v, LY2469298, CAS: 1169956-08-4

Background

Ocaratuzumab, previously known as AME-133v, is a humanized IgG1 type monoclonal antibody targeted at CD20 antigen, which is expressed on B-lymphocytes. Ocaratuzumab is a novel Fc-engineered monoclonal antibody designed by Applied Molecular Evolution in an attempt to induce effective antibody-dependent cell-mediated cytotoxicity (ADCC) at very low concentrations that may facilitate sub-cutaneous dosing. Libraries of antibody Fab fragment regions were generated with codon substituted variations of the antibody complementarity determining regions (CDRs) inserted into human antibody light and heavy chain germline frameworks. Then, the researchers expressed and selected mutants based on increased affinity for CD20. A variable region with increased binding activity for CD20 was selected and developed as ocaratuzumab. This drug is currently being developed by Mentrik Biotech and has been investigated in the trial for the treatment of cancer and autoimmune disorders. The pre-clinical trials of ocaratuzumab in follicular lymphoma was conducted in the United States (US) and Japan in phase I/II, and a Phase I trial was conducted in US rheumatoid arthritis patients. In addition, a phase III trial in relapsed follicular lymphoma patients is underway. Compared to rituximab, ocaratuzumab was shown to ocaratuzumab was shown to have 13 to 20 fold greater affinity for CD20 and 6 fold more potent ADCC in pre-clinical studies. The use of ocaratuzumab in other oncology and rheumatology indications has also been developed.

Data Image
References

Bird-window collisions: A comprehensive dataset for the Neotropical region., PMID:40509845

Can a Portable Flash Visual Evoked Potential (VEP) Device Identify Chiasmal Decussation Anomalies in Albinism?, PMID:40506967

Donor-recipient sex mismatch does not affect graft survivorship after knee osteochondral allograft transplantation., PMID:40505424

Improving occlusal caries detection using optical clearing agent for optical coherence tomography., PMID:40500425

Effects of hyaluronic acid with different molecular weights and concentrations on skin optical clearing and collagen fibril structural characteristics., PMID:40494477

Emerging role of peroxisome proliferator-activated receptor agonists in the treatment of cholestatic liver disease., PMID:40470994

Contrasting clonal and population genetic structure in two endangered Costa Rican Vanilla species of commercial interest., PMID:40456827

Large-seeded plants dispersed by tent-roosting bats along an altitudinal gradient in Costa Rica., PMID:40447913

First records of Amblyomma geayi and Amblyomma varium (Ixodida: Ixodidae) parasitizing sloths in Nicaragua., PMID:40434476

Protective Effect of Obeticholic Acid on Sepsis-Induced Liver Dysfunction via Regulating Bile Acid Homeostasis., PMID:40430579

Changes in occlusal function after surgical and nonsurgical treatment of anterior crossbite: A 2-year follow-up., PMID:40423605

Osteochondral Allograft Transplantation for Large Osteochondral Lesions of the Femoral Head in Young Patients., PMID:40421974

Editorial Commentary: Osteochondral Allograft Outcomes Are Durable at Longer Follow-Up., PMID:40419171

Typical presentation of autosomal recessive oculocutaneous albinism in two siblings., PMID:40416789

Impact of albuminuria screening in primary care on the detection and management of chronic kidney disease: findings from the ONDAAS study., PMID:40416393

Long-term maxillary stability after fixation with two or four plates: a 3-D prospective quasi-experimental evaluation., PMID:40399181

LEADS - a comprehensive human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing., PMID:40391591

Enhancing genetic transformation efficiency of melon (Cucumis melo L.) through an extended sucrose-removal co-culture., PMID:40387942

Antibacterial and preservation properties of eugenol/diatomite modified superamphiphobic polyurethane films with secondary slow-release microstructures., PMID:40382907

Developing Snack Products Based on Oca (Oxalis tuberosa) and Sorghum (Sorghum spp.) Flour: Correlation Between Antioxidant and Physicochemical Properties., PMID:40377760

New Species of Oochoristica Lühe, 1898 (Cestoda: Linstowiinae) from Sceloporus ochoterenae (Reptilia: Sauria: Phrynosomatidae) in Central Mexico: Approach to the Phylogenetic Relationships of the Genus with Molecular Evidence : Oochoristica Maccoyi N. Sp. (Cestoda: Linstowiidae) from Anolis gingivinus (Sauria: Polychrotidae) Collected in Anguilla, Lesser Antilles., PMID:40377750

[Analysis of TYR gene variant in a patient with Oculocutaneous albinism]., PMID:40372228

Targeting farnesoid X receptor as aging intervention therapy., PMID:40370561

Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation., PMID:40364837

Clinico-pathologic profile of skin cancers in oculocutaneous albinism at Universitas Academic Hospital., PMID:40357250

Sex-Based Differences in Clinically Significant Outcome Achievement Following Primary Osteochondral Allograft Transplantation of the Knee at a Minimum 5-Year Follow-up., PMID:40356231

Osteochondral Allograft Chondrocyte Viability Is Affected During Harvest by Irrigation Temperature and Reamer Speed., PMID:40353510

Molecular Characterization of Oculocutaneous Albinism in Consanguineous Pakistani Families: Unraveling Disease-Causing Pathogenic Variants in OCA2 and TYR Genes for Precision Diagnosis., PMID:40343539

FXR protects against neonatal sepsis by enhancing the immunosuppressive function of MDSCs., PMID:40335739

Platelet secretion defects and increased CD63 expression in Hermansky-Pudlak syndrome" a case report., PMID:40333031

Magnetic and MRI Contrast Properties of HumAfFt-SPIONs: Investigating Superparamagnetic Behavior and Enhanced T2-Weighted Imaging Performance., PMID:40331980

Variation of optical properties of mouse brain using an optical clearing agent: experimental and simulation approaches., PMID:40321998

Digital Occlusal Contact Area Indicates Masticatory Performance for Normal Occlusion, but Not for Malocclusion., PMID:40320642

Ultrasound-driven ROS-scavenging nanobubbles for synergistic NASH treatment via FXR activation., PMID:40318601

Quality Measures to Enhance the Management and Treatment of Primary Biliary Cholangitis: A Delphi Consensus Study., PMID:40318123

Re: Dijkmans AL, Laane CLE, Fernandez Dell'Oca A, Jupiter JB, Garg R, Bhashyam AR, Binary Soong grading as a predictor for flexor pollicis longus tendon rupture after distal radial fracture fixation: a retrospective study., PMID:40314200

Case Report: Genetic analysis of oculocutaneous albinism type 2 caused by a new mutation in the OCA2., PMID:40313672

Progress With Shortcomings: An Examination of Demographic Representation in Integrated Plastic Surgery Residencies., PMID:40310000

Lateral Meniscus Allograft Transplant With Capsulodesis and an Osteochondral Allograft to the Lateral Femoral Condyle., PMID:40309488

Treatment of Medial Patellar Instability With Bipolar Patellofemoral Cartilage Lesions: Staged De-rotational Distal Femoral Osteotomy Followed by Bipolar Osteochondral Allograft Transplantation and Tibial-Tubercle Osteotomy., PMID:40309054

Osteochondral Allograft Transplantation: A Technical Note., PMID:40309046

There and back again: historical biogeography of neotropical magnolias based on high-throughput sequencing., PMID:40301707

OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination., PMID:40299553

Nonlinear optical properties of stable Cs-doped FAPbBr3 core@shell layered perovskite nanocrystals: superior temperature sensing and flexible fiber-based pure green LEDs., PMID:40296749

Emotional cartography of urban fear: Methodological approach to analyse the relationship between built environment and fear of crime., PMID:40292186

Individual and mixture effect of selected high-hazard pharmaceuticals on aquatic primary producers., PMID:40287884

Scale of Subtle Prejudices Towards Disability at the University: Validation in Mexican Population., PMID:40277868

Comparative transcriptomic analysis reveals a differential acid response mechanism between estuarine oyster (Crassostrea ariakensis) and Pacific oyster (Crassostrea gigas)., PMID:40273612

Farnesoid X receptor agonist accelerates ammonium metabolism of mesenchymal stem cell-derived hepatocyte-like cells., PMID:40268456

Automatic joint segmentation and classification of breast ultrasound images via multi-task learning with object contextual attention., PMID:40265029

Datasheet

Document Download

Ocaratuzumab ELISA Kit.pdf

 

$ 1128
Product specifications
96 T 1128

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Ocaratuzumab ELISA Kit [KDC90707]
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