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Research Grade Tanezumab (DHB91701)

Host species:Humanized
Isotype:IgG2-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHB91701

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

Beta-nerve growth factor, NGFB, Beta-NGF, NGF

Concentration

1.54 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01138

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

PF-04383119, RN624, CAS: 880266-57-9

Clone ID

Tanezumab

Data Image
  • Bioactivity
    Detects Human NGF in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Tanezumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

[Update Osteoarthritis], PMID: 32167252

A multiple-dose toxicity study of tanezumab in cynomolgus monkeys, PMID: 21130822

Antibodies to watch in 2019, PMID: 30516432

Antibodies to watch in 2020, PMID: 31847708

Antibodies to watch in 2021, PMID: 33459118

Bioanalytical assays in support of tanezumab developmental and reproductive toxicity studies: challenges and learnings, PMID: 31204868

Clinical Outcomes of Tanezumab With Different Dosages for Patient With Osteoarthritis: Network Meta-Analysis, PMID: 34177562

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial, PMID: 31265100

Effects of tanezumab on satellite glial cells in the cervicothoracic ganglion of cynomolgus monkeys: A 26-week toxicity study followed by an 8-week recovery period, PMID: 30890348

Efficacy and safety of intravenous tanezumab for the symptomatic treatment of osteoarthritis: 2 randomized controlled trials versus naproxen, PMID: 25274899

Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial, PMID: 23852695

Efficacy and safety of tanezumab administered as a fixed dosing regimen in patients with knee or hip osteoarthritis: a meta-analysis of randomized controlled phase III trials, PMID: 33159281

Efficacy and safety of tanezumab in the treatment of chronic low back pain, PMID: 21696889

Efficacy and safety of tanezumab in the treatment of pain from bone metastases, PMID: 25919474

Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain, PMID: 24625625

Efficacy and Safety of Tanezumab on Osteoarthritis Knee and Hip Pains: A Meta-Analysis of Randomized Controlled Trials, PMID: 28034979

Efficacy and safety of tanezumab versus naproxen in the treatment of chronic low back pain, PMID: 23628600

Erratum: Pooled Analysis of Tanezumab Efficacy and Safety with Subgroup Analyses of Phase III Clinical Trials in Patients with Osteoarthritis Pain of the Knee or Hip [Corrigendum], PMID: 32982389

Exploring the role of tanezumab as a novel treatment for the relief of neuropathic pain, PMID: 25594611

First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain, PMID: 29922745

From the Cover: Evaluation of the Effects of Tanezumab, a Monoclonal Antibody Against Nerve Growth Factor, on the Sympathetic Nervous System in Adult Cynomolgus Monkeys (Macaca fascicularis): A Stereologic, Histomorphologic, and Cardiofunctional Assessment, PMID: 28525647

Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain, PMID: 24937440

Long-Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial, PMID: 33538113

Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment, PMID: 25073573

NGF/TrkA Signaling as a Therapeutic Target for Pain, PMID: 26452158

Onset and maintenance of efficacy of subcutaneous tanezumab in patients with moderate to severe osteoarthritis of the knee or hip: A 16-week dose-titration study, PMID: 32252976

Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic, PMID: 31026504

Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip, PMID: 30936738

Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis, PMID: 21420111

Relative efficacy and tolerability of 2.5, 5, and 10 mg tanezumab for the treatment of osteoarthritis: A Bayesian network meta-analysis of randomized controlled trials based on patient withdrawal, PMID: 33141017

Response to: "Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis", PMID: 30774242

Response to: 'Use of tanezumab for patients with hip and knee osteoarthritis with reference to a randomised clinical trial by Berenbaum and colleagues' by Riddle and Perera, PMID: 32424029

Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis, PMID: 29386912

Safety of Low-Dose Tanezumab in the Treatment of Hip or Knee Osteoarthritis: A Systemic Review and Meta-analysis of Randomized Phase III Clinical Trials, PMID: 33141224

Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period, PMID: 32234715

Subcutaneous tanezumab for osteoarthritis: Is the early improvement in pain and function meaningful and sustained?, PMID: 33728717

Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety, PMID: 32453139

Tanezumab for Painful Osteoarthritis, PMID: 31265081

Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis, PMID: 27294371

Tanezumab for the treatment of pain from osteoarthritis of the knee, PMID: 20942668

Tanezumab improves difficult-to-treat OA, PMID: 32367021

Tanezumab in the treatment of chronic musculoskeletal conditions, PMID: 27936977

Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial, PMID: 23553790

Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial, PMID: 22784777

Tanezumab Reduces Pain in Women with Interstitial Cystitis/Bladder Pain Syndrome and Patients with Nonurological Associated Somatic Syndromes, PMID: 26576710

Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain, PMID: 20140821

Tanezumab: a selective humanized mAb for chronic lower back pain, PMID: 29503555

Tanezumab: Finally a Monoclonal Antibody for Pain Relief, PMID: 30111960

Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis, PMID: 29643634

Use of tanezumab for patients with hip and knee osteoarthritis with reference to a randomised clinical trial by Berenbaum and colleagues, PMID: 32321719

Datasheet

Document Download

Research Grade Tanezumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Tanezumab [DHB91701]
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