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Research Grade Naglazyme/Galsulfase

Catalog #:   DHD13229 Specific References (98) DATASHEET
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Accession: P15848
Overview

Catalog No.

DHD13229

Expression system

Mammalian Cells

Species reactivity

Human

Applications

Research Grade Biosimilar

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Ion Exchange Chromatography.

Accession

P15848

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

G4S, ASB, N-acetylgalactosamine-4-sulfatase, ARSB, Arylsulfatase B

Clone ID

Naglazyme

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
References

Enzyme replacement therapy attenuates disease progression in two Japanese siblings with mucopolysaccharidosis type VI., PMID:21930407

Abnormal granulation of blood granulocytes in mucopolysaccharidosis VI-a case report., PMID:22056033

Design, baseline characteristics, and early findings of the MPS VI (mucopolysaccharidosis VI) Clinical Surveillance Program (CSP)., PMID:22127392

Therapy for the mucopolysaccharidoses., PMID:22210671

Enzyme replacement therapy for mucopolysaccharidosis VI: long-term cardiac effects of galsulfase (Naglazyme®) therapy., PMID:22669363

Successful desensitization in a type VI mucopolysaccharidosis patient with probable IgE-mediated allergy to galsulfase [Naglazyme]., PMID:23244660

Enzyme replacement therapy with galsulfase in 34 children younger than five years of age with MPS VI., PMID:23535281

Mucopolysaccharidosis type VI phenotypes-genotypes and antibody response to galsulfase., PMID:23557332

Effect of rapid cessation of enzyme replacement therapy: a report of 5 more cases., PMID:24060239

Galsulfase (Naglazyme®) therapy in infants with mucopolysaccharidosis VI., PMID:24108527

Early initiation of enzyme replacement therapy for the mucopolysaccharidoses., PMID:24388732

Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome)--10-year follow-up of patients who previously participated in an MPS VI Survey Study., PMID:24764221

[Mucopolysaccharidosis type VI: clinical aspects, diagnosis and treatment with enzyme replacement therapy]., PMID:24862809

Growth Charts for Individuals with Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome)., PMID:25518809

Enzymes approved for human therapy: indications, mechanisms and adverse effects., PMID:25648140

Mucopolysaccharidosis type VI on enzyme replacement therapy since infancy: Six years follow-up of four children., PMID:28649537

[Management of mucopolysaccharidosis type VI in adults]., PMID:26502669

Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6months of therapy in cats using different IV infusion durations., PMID:26776148

Clinical Evolution After Enzyme Replacement Therapy in Twins with the Severe Form of Maroteaux-Lamy Syndrome., PMID:26920906

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI., PMID:26943923

Rapid Desensitization for Immediate Hypersensitivity to Galsulfase Therapy in Patients with MPS VI., PMID:26951141

Long-term galsulfase enzyme replacement therapy in Taiwanese mucopolysaccharidosis VI patients: A case series., PMID:27134829

A Desensitization Method to Maintain Enzyme Replacement Therapy in Mucopolysaccharidosis Type VI., PMID:27164636

Is premedication a necessity before galsulfase replacement therapy?, PMID:27346567

The effect of galsulfase enzyme replacement therapy on the growth of patients with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)., PMID:28457718

Enzyme replacement therapy attenuates disease progression in two Japanese siblings with mucopolysaccharidosis type VI: 10-Year follow up., PMID:28983456

Lysosomal storage diseases., PMID:29152458

Family study of a novel mutation of mucopolysaccharidosis type VI with a severe phenotype and good response to enzymatic replacement therapy: Case report., PMID:30335002

Clinical effectiveness of enzyme replacement therapy with galsulfase in mucopolysaccharidosis type VI treatment: Systematic review., PMID:30740728

Enzyme replacement therapy outcomes across the disease spectrum: Findings from the mucopolysaccharidosis VI Clinical Surveillance Program., PMID:30834539

Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance., PMID:31142378

Enzyme replacement therapy initiated in adulthood: Findings from the mucopolysaccharidosis VI Clinical Surveillance Program., PMID:31324526

[Cardiovascular findings and effects of enzyme replacement therapy in patients with mucopolysaccharidosis type VI]., PMID:31582674

Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations., PMID:32340185

Enzyme Replacement Therapy may Affect Blood Immunosuppressant Monitoring., PMID:32379593

Home treatment of type VI mucopolysaccharidosis (Maroteaux-Lamy syndrome) an alternative at this time of COVID-19 pandemic: A case in Peru., PMID:33363956

Long-term impact of early initiation of enzyme replacement therapy in 34 MPS VI patients: A resurvey study., PMID:33678523

Long-term outcomes of patients with mucopolysaccharidosis VI treated with galsulfase enzyme replacement therapy since infancy., PMID:33775523

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI., PMID:34533215

Clinical and event-based outcomes of patients with mucopolysaccharidosis VI receiving enzyme replacement therapy in Turkey: a case series., PMID:34666789

Effectiveness of drug postmarketing all-case surveillance as a safety measure in Japan., PMID:34987750

Fifteen years of enzyme replacement therapy for mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): a case report., PMID:35078524

Novel chorioretinal findings in two siblings with mucopolysaccharidosis type VI., PMID:35658818

Real-world pharmacovigilance analysis of galsulfase: a study based on the FDA adverse event reporting system (FAERS) database., PMID:39161895

Histopathological and Clinical-Genetic Analysis of Corneal Specimens in Maroteaux-Lamy Syndrome., PMID:40079783

Efficacy of different treatment strategies in patients with mucopolysaccharidosis: a systematic review and network meta-analysis of randomized controlled trials., PMID:40317013

Long-term enzyme replacement therapy: Findings from the mucopolysaccharidosis VI clinical surveillance program after 15 years follow-up., PMID:40381595

Carpal Tunnel Syndrome Attributed to Medication Use: A Pharmacovigilance Study., PMID:40510111

[Overview of enzyme replacement therapy in mucopolysaccharidosis], PMID: 17546776

Joint contractures in the absence of inflammation may indicate mucopolysaccharidosis, PMID: 19852785

Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome) with a predominantly cardiac phenotype, PMID: 21917494

Long-term impact of early initiation of enzyme replacement therapy in 34 MPS VI patients: A resurvey study, PMID: 33678523

[Cardiovascular findings and effects of enzyme replacement therapy in patients with mucopolysaccharidosis type VI], PMID: 31582674

[Mucopolysaccharidosis type VI: clinical aspects, diagnosis and treatment with enzyme replacement therapy], PMID: 24862809

[Management of mucopolysaccharidosis type VI in adults], PMID: 26502669

Home treatment of type VI mucopolysaccharidosis (Maroteaux-Lamy syndrome) an alternative at this time of COVID-19 pandemic: A case in Peru, PMID: 33363956

Current enzyme replacement therapy for the treatment of lysosomal storage diseases, PMID: 19725195

Thrombocytopenia associated with galsulfase treatment, PMID: 20670992

Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6months of therapy in cats using different IV infusion durations, PMID: 26776148

Early initiation of enzyme replacement therapy for the mucopolysaccharidoses, PMID: 24388732

[Enzyme replacement therapy of lysosomal storage diseases], PMID: 21211680

Long-term outcomes of patients with mucopolysaccharidosis VI treated with galsulfase enzyme replacement therapy since infancy, PMID: 33775523

Enzyme replacement therapy for the management of the mucopolysaccharidoses, PMID: 20040314

Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI): a single dose of galsulfase further reduces urine glycosaminoglycans after hematopoietic stem cell transplantation, PMID: 20800524

Enzymes approved for human therapy: indications, mechanisms and adverse effects, PMID: 25648140

Natural history and galsulfase treatment in mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome)--10-year follow-up of patients who previously participated in an MPS VI Survey Study, PMID: 24764221

A systematic review of new advances in the management of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): focus on galsulfase, PMID: 19851471

Growth Charts for Individuals with Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome), PMID: 25518809

Recent Advances in Treatment Approaches of Mucopolysaccharidosis VI, PMID: 21506914

Lysosomal storage diseases, PMID: 18720909

Home treatment with Elaprase and Naglazyme is safe in patients with mucopolysaccharidoses types II and VI, respectively, PMID: 18923918

Therapy for the mucopolysaccharidoses, PMID: 22210671

Enzyme replacement therapy outcomes across the disease spectrum: Findings from the mucopolysaccharidosis VI Clinical Surveillance Program, PMID: 30834539

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis VI: clinical facts and figures, PMID: 21434527

The effect of galsulfase enzyme replacement therapy on the growth of patients with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), PMID: 28457718

Enzyme replacement therapy initiated in adulthood: Findings from the mucopolysaccharidosis VI Clinical Surveillance Program, PMID: 31324526

Enzyme Replacement Therapy may Affect Blood Immunosuppressant Monitoring, PMID: 32379593

Successful management of difficult infusion-associated reactions in a young patient with mucopolysaccharidosis type VI receiving recombinant human arylsulfatase B (galsulfase [Naglazyme]), PMID: 18250117

Enzyme replacement therapy with galsulfase in 34 children younger than five years of age with MPS VI, PMID: 23535281

Clinical effectiveness of enzyme replacement therapy with galsulfase in mucopolysaccharidosis type VI treatment: Systematic review, PMID: 30740728

Successful desensitization in a type VI mucopolysaccharidosis patient with probable IgE-mediated allergy to galsulfase [Naglazyme], PMID: 23244660

Is premedication a necessity before galsulfase replacement therapy?, PMID: 27346567

Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme) therapy, PMID: 18418554

Mucopolysaccharidosis type VI phenotypes-genotypes and antibody response to galsulfase, PMID: 23557332

Long-term galsulfase enzyme replacement therapy in Taiwanese mucopolysaccharidosis VI patients: A case series, PMID: 27134829

Recommendations for the management of MPS VI: systematic evidence- and consensus-based guidance, PMID: 31142378

Development, validation, and clinical implementation of an assay to measure total antibody response to naglazyme (galsulfase), PMID: 18607760

Rapid Desensitization for Immediate Hypersensitivity to Galsulfase Therapy in Patients with MPS VI, PMID: 26951141

Comparison of neutralizing antibody assays for receptor binding and enzyme activity of the enzyme replacement therapeutic Naglazyme (galsulfase), PMID: 18709516

Mucopolysaccharidosis VI, PMID: 20385007

Enzyme replacement therapy for mucopolysaccharidosis VI: long-term cardiac effects of galsulfase (Naglazyme®) therapy, PMID: 22669363

Galsulfase: arylsulfatase B, BM 102, recombinant human arylsulfatase B, recombinant human N-acetylgalactosamine-4-sulfatase, rhASB, PMID: 16128602

Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI, PMID: 26943923

Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations, PMID: 32340185

Galsulfase, PMID: 16521329

Galsulfase (Naglazyme®) therapy in infants with mucopolysaccharidosis VI, PMID: 24108527

Lysosomal storage diseases, PMID: 29152458

Galsulfase (Naglazyme) [Internet], PMID: 28121110

Datasheet
$ 420
Product specifications
100 μg 420 1 mg 1680 5 mg 5040

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For research use only. Not for human or drug use.

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Research Grade Naglazyme/Galsulfase [DHD13229]
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