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Research Grade Aflibercept (DHD12629)

Host species:Human
Isotype:IgG1-Fc
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHD12629

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-Fc

Clonality

Monoclonal

Target

Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A

Concentration

2.37 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15692

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAS: 862111-32-8

Clone ID

Aflibercept

Data Image
  • Bioactivity
    Detects Human VEGFA in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Aflibercept
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration, PMID: 23084240

Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema: Two-Year Results from a Comparative Effectiveness Randomized Clinical Trial, PMID: 26935357

Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema: recent clinically relevant findings from DRCR.net Protocol T, PMID: 28837425

Intravitreal Ziv-Aflibercept: A Comprehensive Review, PMID: 31314638

Aflibercept for neovascular age-related macular degeneration, PMID: 26857947

SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB, PMID: 28106709

Brolucizumab Versus Aflibercept in Participants with Neovascular Age-Related Macular Degeneration: A Randomized Trial, PMID: 28551167

Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema With Vision Impairment: A Secondary Analysis of a Randomized Clinical Trial, PMID: 29392288

Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab): Case Series and Nephrological Considerations, PMID: 32664269

Ranibizumab or Aflibercept for Diabetic Macular Edema: Comparison of 1-Year Outcomes from the Fight Retinal Blindness! Registry, PMID: 31932092

Aflibercept, PMID: 23444216

The cost-effectiveness of bevacizumab, ranibizumab and aflibercept for the treatment of age-related macular degeneration-A cost-effectiveness analysis from a societal perspective, PMID: 29772018

Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen, PMID: 22949147

HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration, PMID: 30986442

Aflibercept, PMID: 22460118

Aflibercept: A review of its effect on the treatment of exudative age-related macular degeneration, PMID: 30813810

Intravitreal aflibercept and ranibizumab for pachychoroid neovasculopathy, PMID: 30765771

Change in Diabetic Retinopathy Through 2 Years: Secondary Analysis of a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab, PMID: 28448655

Aflibercept: A Review in Metastatic Colorectal Cancer, PMID: 26220913

Real-World Effectiveness and Real-World Cost-Effectiveness of Intravitreal Aflibercept and Intravitreal Ranibizumab in Neovascular Age-Related Macular Degeneration: Systematic Review and Meta-Analysis of Real-World Studies, PMID: 31728825

A Randomized, Double-Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Patients with Visual Impairment due to Diabetic Macular Edema (KITE), PMID: 32131127

Intravitreal Ziv-Aflibercept: Clinical Effects and Economic Impact, PMID: 28971631

Aflibercept: A Review of Its Use in the Management of Diabetic Eye Complications, PMID: 27166390

Potential of subconjunctival aflibercept in treating choroidal neovascularization, PMID: 32795527

Aflibercept (VEGF-TRAP): the next anti-VEGF drug, PMID: 21999177

Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD, PMID: 25001321

Aflibercept: A Review in Macular Oedema Secondary to Branch Retinal Vein Occlusion, PMID: 28365905

Ziv-aflibercept (Zaltrap) for the treatment of metastatic colorectal cancer, PMID: 24259608

Aflibercept: A Review of Its Use in Diabetic Macular Oedema, PMID: 26056030

Intravitreal Aflibercept in Diabetic Macular Edema: Long-Term Outcomes, PMID: 28427067

Aflibercept in the Treatment of Diabetic Macular Edema: A Review and Consensus Paper, PMID: 29077188

Transport and fate of aflibercept in VEGF-A 165-challenged retinal endothelial cells, PMID: 32712182

Aflibercept in age-related macular degeneration: evaluating its role as a primary therapeutic option, PMID: 28548650

Aflibercept for the treatment of diabetic macular edema, PMID: 26907516

Influence of aflibercept on platelet activation profile, PMID: 29908884

A preclinical and clinical review of aflibercept for the management of cancer, PMID: 22264850

Aflibercept for age-related macular degeneration: a game-changer or quiet addition?, PMID: 22813448

Switching between ranibizumab and aflibercept for the treatment of neovascular age-related macular degeneration, PMID: 29476754

Intravitreal aflibercept injection in Indian eyes with retinopathy of prematurity, PMID: 31124509

Aflibercept for intravitreal injection: in neovascular age-related macular degeneration, PMID: 23038609

Ziv-aflibercept: a novel angiogenesis inhibitor for the treatment of metastatic colorectal cancer, PMID: 24128964

Aflibercept a new target therapy in cancer treatment: a review, PMID: 26224565

Evaluation of aflibercept in the treatment of metastatic colorectal cancer, PMID: 25152076

INTRAVITREAL AFLIBERCEPT AND RANIBIZUMAB INJECTIONS FOR TYPE 3 NEOVASCULARIZATION, PMID: 28984737

HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration, PMID: 32574761

Ranibizumab and aflibercept for the treatment of wet age-related macular degeneration, PMID: 26076760

Aflibercept regulates retinal inflammation elicited by high glucose via the PlGF/ERK pathway, PMID: 31351870

PHARMACOKINETIC STUDY OF INTRAVITREAL AFLIBERCEPT IN HUMANS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION, PMID: 31145389

Aflibercept (eylea) for age-related macular degeneration, PMID: 22354219

Aflibercept: an update on recent milestones achieved, PMID: 25588083

Datasheet

Document Download

Research Grade Aflibercept.pdf

 

$ 426
Product specifications
100 μg 426 1 mg 1704

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Research Grade Aflibercept [DHD12629]
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