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Recombinant Human DSG3 Protein

Catalog #:   AID00301 Specific References (50) DATASHEET
Applications: As a diagnostic tool for Pemphigus vulgaris (PV).
Expression system: Confidential
Accession: P32926
Protein length: Confidential
Overview

Catalog No.

AID00301

Description

Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.

Expression system

Confidential

Species

Homo sapiens (Human)

Protein length

Confidential

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Accession

P32926

Applications

As a diagnostic tool for Pemphigus vulgaris (PV).

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Cadherin family member 6, DSG3, Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, CDHF6

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human DSG3
References

Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study., PMID:40481453

Factors associated with persistent anti-desmoglein positivity after remission in pemphigus vulgaris: a prospective registry-based cohort study., PMID:40433384

Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion., PMID:40299565

Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy., PMID:40295683

[CAR-T cells in Dermatology: Mechanisms of action and applications in autoimmune diseases]., PMID:40279442

Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor., PMID:40120680

Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus., PMID:40059466

Molecular Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients., PMID:40018925

Prevalence and pathogenic activity of anti-desmocollin-3 antibodies in patients with pemphigus vulgaris and pemphigus foliaceus., PMID:39989391

Optimizing Pemphigus Management With Rituximab and Short-Term Relapse Predictors., PMID:39908046

The impact of signaling pathways on the desmosome ultrastructure in pemphigus., PMID:39882246

Case report: A rollercoaster journey of pemphigus vegetans., PMID:39872528

Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence., PMID:39460496

Quality-controlled characterization of a monoclonal antibody specific to an EC5-domain of human desmoglein 3 for pemphigus research., PMID:39450179

IgG reactivity to different desmoglein-3 ectodomains in pemphigus vulgaris: novel panels for assessing disease severity., PMID:39416775

Human dental mesenchymal stem cells restorate immune response in sera of pemphigus vulgaris patients., PMID:39352524

Effect of opioid receptor antagonist on mitigating tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced apoptolysis in pemphigus pathogenesis., PMID:39276627

Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus., PMID:39271654

Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris-A retrospective study., PMID:39246287

Standardized Production of Anti-Desmoglein 3 Antibody AK23 for Translational Pemphigus Vulgaris Research., PMID:39169810

Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus., PMID:39152677

Direct immunofluorescence on plucked hair outer root sheath can predict relapse in pemphigus vulgaris., PMID:39086016

Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris., PMID:39037929

Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3., PMID:38900156

Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus., PMID:38851894

The emergence of circulating activated autoreactive desmoglein 3-specific follicular regulatory T cells is associated with long-term efficacy of rituximab in patients with pemphigus vulgaris., PMID:38848544

Absence of Epidermal Antibodies in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Patients but Beware of Single Positive Results., PMID:38803350

A case of bullous pemphigoid complicated by mucosal lesions due to mucosal-dominant pemphigus vulgaris: analyzing the pathogenicity of anti-desmoglein 3 antibodies using a bead aggregation assay., PMID:38741281

Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus., PMID:38677661

EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis., PMID:38642796

Clinical and immunological predictors of post-rituximab paradoxical pemphigus flare: A prospective cohort study., PMID:38595008

Differences among Indian and European pemphigus patients based on demographics, clinical parameters and propensity for relapse: results of a prospective bicontinental cohort study., PMID:38465545

Rituximab in the Management of Autoimmune Bullous Diseases: A Treatment-Resistant Case Series from a Single Central European Referral Center., PMID:38399557

ERK/MEK Pathway Regulates Th17 Cell Differentiation in Patients with Pemphigus Vulgaris., PMID:38371571

Aspirin-exacerbated respiratory disease is associated with variants in filaggrin, epithelial integrity, and cellular interactions., PMID:38317805

Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial., PMID:38265821

JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes., PMID:38227055

Novel nanoparticle AuNCs conjugated with Desmoglein-3 antibody for FL/CT dual-mode targeted imaging and precise treatment of lung squamous cell carcinoma., PMID:38224630

A case of anti-laminin γ1 (p200) pemphigoid developed after dipeptidyl peptidase-4 inhibitor administration., PMID:38214494

Pemphigus vulgaris relapsed with serological shift from single-positive desmoglein-3 antibodies to single-positive desmoglein-1 antibodies., PMID:38212901

A case of paraneoplastic pemphigus associated with follicular lymphoma positive only for anti-desmoglein 3 antibody., PMID:38111329

Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple-negative breast cancer., PMID:38090381

Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells., PMID:38067138

Ferroptosis-related genes prognostic signature for pancreatic cancer and immune infiltration: potential biomarkers for predicting overall survival., PMID:38007403

Treatment with a red-laser-based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing., PMID:37957888

Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation., PMID:37940861

Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa., PMID:37850634

Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88., PMID:37719363

Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris., PMID:37717934

Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays., PMID:37524667

Datasheet
$ 480
Product specifications
100 μg 480 1 mg 2880

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Recombinant Human DSG3 Protein [AID00301]
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