Catalog No.
AID00201
Description
Desmoglein 1 (DSG1), the Pemphigus Foliaceus (PF) antigen, is produced as a precursor (preDSG1) and is transported to the cell surface as the mature form (matDSG1). Pemphigus foliaceus (PF) is an organ-specific autoimmune cutaneous disease characterized clinically by the development of superficial blisters and erosions of skin, histologically by loss of cell adhesion of keratinocytes in the upper part of epidermis, and immunologically by in vivo bound and circulating IgG autoantibodies directed against desmoglein 1 (Dsg1), a transmembrane desmosomal glycoprotein to the cadherin family.
Expression system
Confidential
Species
Homo sapiens (Human)
Protein length
Confidential
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02413
Applications
As a diagnostic tool for Pemphigus Foliaceus (PF).
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DGI, Cadherin family member 4, Desmoglein-1, DG1, Pemphigus foliaceus antigen, CDHF4, DSG1, Desmosomal glycoprotein 1
Gene expression study in the siRNA based aniridia cell model and in primary aniridia limbal epithelial cells following duloxetine and ritanserin treatment., PMID:40493651
Factors associated with persistent anti-desmoglein positivity after remission in pemphigus vulgaris: a prospective registry-based cohort study., PMID:40433384
Discovery of new protein partners of anterior gradient 2 (AGR2) from cell-cell adhesion pathway using genetically-encoded photo-crosslinker DiZPK., PMID:40367911
Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of Prinsepia utilis Royle Polysaccharides and Nonapeptide Co-Application., PMID:40367144
Loss-of-function variants in DUSP1 encoding dual specificity phosphatase 1 cause palmoplantar keratoderma., PMID:40359362
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324
Effect of isolated keratin 3 knockdown on gene expression of primary limbal epithelial cells without and with inflammatory stimuli., PMID:40334825
Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion., PMID:40299565
The Overlap of Allergic Disorders and Upper Gastrointestinal Symptoms: Beyond Eosinophilic Esophagitis., PMID:40284218
OsBSK3 and OsBSK2 regulate grain size and leaf angle via MAPK signaling pathway in rice., PMID:40254664
Clinical Responses and Transcriptomic Analysis of Spesolimab in a Girl With Severe Dermatitis, Multiple Allergies and Metabolic Wasting Syndrome., PMID:40207438
Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor., PMID:40120680
Decreased PAX6 and DSG1 Protein Expression in Corneal Epithelium of Patients with Epithelial Basal Membrane Dystrophy, Salzmann Nodular Degeneration, and Pterygium., PMID:40094891
Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus., PMID:40059466
Prevalence and pathogenic activity of anti-desmocollin-3 antibodies in patients with pemphigus vulgaris and pemphigus foliaceus., PMID:39989391
The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling., PMID:39963517
Optimizing Pemphigus Management With Rituximab and Short-Term Relapse Predictors., PMID:39908046
The impact of signaling pathways on the desmosome ultrastructure in pemphigus., PMID:39882246
Pemphigus Foliaceus Mimicking Ichthyosis: A Rare Clinical Presentation., PMID:39734965
G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo., PMID:39650661
SAM Syndrome Presenting With Pulmonary Stenosis: A Case Report and Literature Review., PMID:39644136
Clinical and Genetic Findings in Patients With Palmoplantar Keratoderma., PMID:39630431
The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength., PMID:39504468
Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation., PMID:39503931
Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence., PMID:39460496
Estradiol-mediated enhancement of the human ectocervical epithelial barrier correlates with desmoglein-1 expression in the follicular menstrual phase., PMID:39439565
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Human dental mesenchymal stem cells restorate immune response in sera of pemphigus vulgaris patients., PMID:39352524
Persistent desmoglein-1 downregulation and periostin accumulation in histologic remission of eosinophilic esophagitis., PMID:39343172
Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro., PMID:39306593
Effect of opioid receptor antagonist on mitigating tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-induced apoptolysis in pemphigus pathogenesis., PMID:39276627
Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris-A retrospective study., PMID:39246287
shRNA-Targeting Caspase-3 Inhibits Cell Detachment Induced by Pemphigus Vulgaris Autoantibodies in HaCaT Cells., PMID:39201550
Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus., PMID:39152677
Biomarkers in Pemphigus Vulgaris: A Systematic Review., PMID:39075718
Immunohistopathological analyses of a case of pemphigus vegetans with antibodies against desmoglein 1 and desmocollins 1-3., PMID:39073162
Effect of benralizumab on histopathology and inflammatory signatures in a clinical cohort of eosinophilic esophagitis., PMID:38986036
Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus., PMID:38851894
S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway., PMID:38842658
The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength., PMID:38712246
Experimental interventions attenuate a conjunctival epidermal metaplasia model., PMID:38679224
EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis., PMID:38642796
Clinical and immunological predictors of post-rituximab paradoxical pemphigus flare: A prospective cohort study., PMID:38595008
Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology., PMID:38542083
Rituximab in the Management of Autoimmune Bullous Diseases: A Treatment-Resistant Case Series from a Single Central European Referral Center., PMID:38399557
Necrotic activity of ExhC from Mammaliicoccus sciuri is mediated by specific amino acid residues., PMID:38287568
Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial., PMID:38265821
Unravelling the mystery: severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome with a novel homozygous mutation in DSG1., PMID:38240109
JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes., PMID:38227055
A case of anti-laminin γ1 (p200) pemphigoid developed after dipeptidyl peptidase-4 inhibitor administration., PMID:38214494
For research use only. Not for human or drug use.
