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Recombinant Human ACE2 Protein, No tag

Catalog #:   EHJ51601 Specific References (100) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: Mammalian Cells
Accession: Q9BYF1
Protein length: Ser19-Ser740
Overview

Catalog No.

EHJ51601

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Ser19-Ser740

Predicted molecular weight

85.2 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>80% as determined by SDS-PAGE.

Accession

Q9BYF1

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Angiotensin-converting enzyme homolog, ACE2, ACEH, Metalloprotease MPROT15, Angiotensin-converting enzyme-related carboxypeptidase, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, SARS-like Coronaviruses

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human ACE2
References

Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease. PMID: 33064147

Cross-species recognition of SARS-CoV-2 to bat ACE2. PMID: 33335073

An update on ACE2 amplification and its therapeutic potential. PMID: 32469114

Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications. PMID: 32901821

Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals. PMID: 32604999

The ACE2/Ang (1-7)/MasR axis as an emerging target for antihypertensive peptides. PMID: 32551837

Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges. PMID: 33296619

ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen. PMID: 33462852

Kidney ACE2 expression: Implications for chronic kidney disease. PMID: 33125431

Cytoplasmic short linear motifs in ACE2 and integrin beta(3) link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy. PMID: 33436498

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon. PMID: 33068560

The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues. PMID: 33008593

ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity. PMID: 33361716

ACE2: The Major Cell Entry Receptor for SARS-CoV-2. PMID: 33170317

ACE2 in the renin-angiotensin system. PMID: 33264412

ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19. PMID: 33231620

ACE2 as therapeutic agent. PMID: 33063820

Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus(1). PMID: 33086021

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. PMID: 33093202

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. PMID: 33389262

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein. PMID: 32249956

ACE2 contributes to the maintenance of mouse epithelial barrier function. PMID: 33097186

ACE2: from protection of liver disease to propagation of COVID-19. PMID: 33284956

ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica. PMID: 32368013

Advances in research on ACE2 as a receptor for 2019-nCoV. PMID: 32780149

Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2). PMID: 32759311

Expression of ACE2 in airways: Implication for COVID-19 risk and disease management in patients with chronic inflammatory respiratory diseases. PMID: 32975865

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells. PMID: 33207245

ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19. PMID: 32901940

ACE2 modulates glucose homeostasis through GABA signaling during metabolic stress. PMID: 32698150

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. PMID: 33206176

The flexibility of ACE2 in the context of SARS-CoV-2 infection. PMID: 33189680

Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. PMID: 33177651

Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of COVID-19. PMID: 32780893

ACE2 activators for the treatment of COVID 19 patients. PMID: 32379346

The role of SARS-CoV-2 target ACE2 in cardiovascular diseases. PMID: 33443816

Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions. PMID: 33196086

GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies. PMID: 33049583

Designed variants of ACE2-Fc that decouple anti-SARS-CoV-2 activities from unwanted cardiovascular effects. PMID: 33080267

ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart. PMID: 33086866

ACE2 and prognosis of COVID-19: Insights from Bartter's and Gitelman's syndromes patients. PMID: 32374416

Pirfenidone: A novel hypothetical treatment for COVID-19. PMID: 32575019

The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. PMID: 32594644

SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae. PMID: 32239522

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM. PMID: 33277323

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor. PMID: 33077916

ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19. PMID: 33305790

ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors. PMID: 32039680

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies. PMID: 32623480

Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2. PMID: 33356169

Potential blocker of SARS-CoV entry and a narrow functionality of its spike protein motifs on Qubevirus platform., PMID:40516871

Recombinant receptor-binding motif of spike COVID-19 vaccine candidate induces SARS-CoV-2 neutralizing antibody response., PMID:40256231

Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct., PMID:40046771

Signaling Transduction Network Elucidation of ACE 2 Regulating Apostichopus japonicus Autolysis by Using Integrative TMT Proteomics and Transcriptomics., PMID:39786724

Amyloidogenesis of SARS-CoV-2 delta plus and omicron variants receptor-binding domain (RBD): impact of SUMO fusion tag., PMID:39182215

TurboID-mediated proximity labeling technologies to identify virus co-receptors., PMID:38994005

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo., PMID:38771062

A cell based assay using virus-like particles to screen AM type mimics for SARS-CoV-2 neutralisation., PMID:38735141

Effective expression and characterization of the receptor binding domains in SARS-CoV-2 Spike proteins from original strain and variants of concern using Bombyx mori nucleopolyhedrovirus in silkworm., PMID:38395208

A Biosensor Assay Based on Coiled-Coil-Mediated Human ACE2 Receptor Capture for the Analysis of Its Interactions with the SARS-CoV-2 Receptor Binding Domain., PMID:38315361

Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens., PMID:38005987

Recombinant rotavirus expressing the glycosylated S1 protein of SARS-CoV-2., PMID:37830788

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo., PMID:37808801

Soluble SARS-CoV-2 RBD and human ACE2 peptidase domain produced in Drosophila S2 cells show functions evoking virus-cell interface., PMID:37405395

Site-Specific Covalent Immobilization of SMA-Stabilized ACE2 for SARS-CoV-2 Recognition and Drug Screening., PMID:37394764

A novel ACE2 decoy for both neutralization of SARS-CoV-2 variants and killing of infected cells., PMID:37383226

Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection., PMID:37338780

Development of an Effective Neutralizing Antibody Assay for SARS-CoV-2 Diagnosis., PMID:37333734

Highly selective and quantitative in situ monitoring of cell surface proteins by SERS immunoassay system., PMID:37148802

SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells., PMID:36889309

Establishment of angiotensin-converting enzyme 2 and cluster of differentiation 147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti severe acute respiratory syndrome coronavirus 2 active components., PMID:36870232

Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein., PMID:36710959

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel®85 Protects K18-hACE2 Mice against Lethal Virus Challenge., PMID:36560529

A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity., PMID:36532082

An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants., PMID:36466631

Utilization of Receptor-Binding Domain of SARS-CoV-2 Spike Protein Expressed in Escherichia coli for the Development of Neutralizing Antibody Assay., PMID:36103078

Utilization of SUMO Tag and Freeze-thawing Method for a High-level Expression and Solubilization of Recombinant Human Angiotensinconverting Enzyme 2 (rhACE2) Protein in E. coli., PMID:35838231

Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics., PMID:35487958

Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding., PMID:35481636

A Multi-Disulfide Receptor-Binding Domain (RBD) of the SARS-CoV-2 Spike Protein Expressed in E. coli Using a SEP-Tag Produces Antisera Interacting with the Mammalian Cell Expressed Spike (S1) Protein., PMID:35163624

SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice., PMID:34815544

Bioengineered angiotensin-converting-enzyme-2: a potential therapeutic option against SARS-CoV-2 infection., PMID:34773078

Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants., PMID:34634927

Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level., PMID:34590603

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates., PMID:34338634

BNT162b2 mRNA SARS-CoV-2 Vaccine Elicits High Avidity and Neutralizing Antibodies in Healthcare Workers., PMID:34207300

A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection., PMID:33758841

Isoelectric point determination by imaged CIEF of commercially available SARS-CoV-2 proteins and the hACE2 receptor., PMID:33533060

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity., PMID:33436573

Design, Expression, Purification, and Characterization of a YFP-Tagged 2019-nCoV Spike Receptor-Binding Domain Construct., PMID:33409271

Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™., PMID:33407110

Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2., PMID:33239166

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2., PMID:33236012

SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination., PMID:33111375

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes., PMID:33091382

Quantitative Proteomic Analysis Reveals the Deregulation of Nicotinamide Adenine Dinucleotide Metabolism and CD38 in Inflammatory Bowel Disease., PMID:31179321

Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites., PMID:28895159

Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast., PMID:27548313

Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients., PMID:27310975

The association between the Angiotensin-Converting Enzyme-2 gene and blood pressure in a cohort study of adolescents., PMID:24191856

Datasheet
$ 480
Product specifications
100 μg 480 1 mg 2880

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For research use only. Not for human or drug use.

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Recombinant Human ACE2 Protein, No tag [EHJ51601]
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