Research Grade Anti-RGMA/RGM Antibody (H116A3)

Catalog No.

DHJ37702

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-Kappa

Clonality

Monoclonal

Target

RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96B86

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

RGMA

Virus-induced RGMa expression drives neurodegeneration in HTLV-1-associated myelopathy., PMID:40305434

Inhibition of repulsive guidance molecule A ameliorates diabetes-induced cognitive decline and hippocampal neurogenesis impairment in mice., PMID:39972167

The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies., PMID:39956860

Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice., PMID:39613526

Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke., PMID:39475454

Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats., PMID:38306928

Comparability of Elezanumab Safety, Tolerability, and Pharmacokinetics in Healthy Japanese, Chinese, and White Participants., PMID:38191982

RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS., PMID:37992159

Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion., PMID:37326791

Phase 1 Evaluation of Elezanumab (Anti-Repulsive Guidance Molecule A Monoclonal Antibody) in Healthy and Multiple Sclerosis Participants., PMID:36093738

Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury., PMID:35810963

Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice., PMID:35784362

Expression and Clinical Correlation Analysis Between Repulsive Guidance Molecule a and Neuromyelitis Optica Spectrum Disorders., PMID:35185873

RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO., PMID:35167145

Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models., PMID:34478849

An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury., PMID:34077429

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates., PMID:33991647

Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease., PMID:33589594

An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure., PMID:33536466

Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats., PMID:32590037

Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury., PMID:31200090

Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome., PMID:30513621

Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis., PMID:30333477

Identification of methylation sites and signature genes with prognostic value for luminal breast cancer., PMID:29642861

Analysis of the miRNA-mRNA-lncRNA network in human estrogen receptor-positive and estrogen receptor-negative breast cancer based on TCGA data., PMID:29518546

Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury., PMID:29315368

Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica., PMID:29311561

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury., PMID:28874746

Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease., PMID:28842419

Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS., PMID:26986456

Quantification of Hepcidin-related Iron Accumulation in the Rat Liver., PMID:26839325

Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke., PMID:25950474

Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis., PMID:25801027

Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation., PMID:25483983

Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis., PMID:25456136

Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells., PMID:24123853

Activated microglia inhibit axonal growth through RGMa., PMID:21957482

RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina., PMID:21887516

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis., PMID:21423182

The repulsive guidance molecule, RGMa, promotes retinal ganglion cell survival in vitro and in vivo., PMID:20457227

Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors., PMID:20161753

RGMA and IL21R show association with experimental inflammation and multiple sclerosis., PMID:20072140

Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse., PMID:19458235

Sustained in vivo inhibition of protein domains using single-chain Fv recombinant antibodies and its application to dissect RGMa activity on axonal outgrowth., PMID:19176821

Intraretinal RGMa is involved in retino-tectal mapping., PMID:18280178

Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury., PMID:17996222

RGMa inhibition promotes axonal growth and recovery after spinal cord injury., PMID:16585268

The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus., PMID:15084667

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