Catalog No.
DHJ37702
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG1-Kappa
Clonality
Monoclonal
Target
RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96B86
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
RGMA
Note
For research use only. Not suitable for clinical or therapeutic use.
The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus., PMID:15084667
RGMa inhibition promotes axonal growth and recovery after spinal cord injury., PMID:16585268
Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury., PMID:17996222
Intraretinal RGMa is involved in retino-tectal mapping., PMID:18280178
Sustained in vivo inhibition of protein domains using single-chain Fv recombinant antibodies and its application to dissect RGMa activity on axonal outgrowth., PMID:19176821
Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse., PMID:19458235
RGMA and IL21R show association with experimental inflammation and multiple sclerosis., PMID:20072140
Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors., PMID:20161753
The repulsive guidance molecule, RGMa, promotes retinal ganglion cell survival in vitro and in vivo., PMID:20457227
RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis., PMID:21423182
RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina., PMID:21887516
Activated microglia inhibit axonal growth through RGMa., PMID:21957482
Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells., PMID:24123853
Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis., PMID:25456136
Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation., PMID:25483983
Targeting repulsive guidance molecule A to promote regeneration and neuroprotection in multiple sclerosis., PMID:25801027
Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke., PMID:25950474
Quantification of Hepcidin-related Iron Accumulation in the Rat Liver., PMID:26839325
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS., PMID:26986456
Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease., PMID:28842419
RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury., PMID:28874746
Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica., PMID:29311561
Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury., PMID:29315368
Analysis of the miRNA-mRNA-lncRNA network in human estrogen receptor-positive and estrogen receptor-negative breast cancer based on TCGA data., PMID:29518546
Identification of methylation sites and signature genes with prognostic value for luminal breast cancer., PMID:29642861
Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis., PMID:30333477
Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome., PMID:30513621
Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury., PMID:31200090
Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats., PMID:32590037
An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure., PMID:33536466
Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease., PMID:33589594
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates., PMID:33991647
An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury., PMID:34077429
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models., PMID:34478849
RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO., PMID:35167145
Expression and Clinical Correlation Analysis Between Repulsive Guidance Molecule a and Neuromyelitis Optica Spectrum Disorders., PMID:35185873
Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice., PMID:35784362
Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury., PMID:35810963
Phase 1 Evaluation of Elezanumab (Anti-Repulsive Guidance Molecule A Monoclonal Antibody) in Healthy and Multiple Sclerosis Participants., PMID:36093738
Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion., PMID:37326791
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS., PMID:37992159
Comparability of Elezanumab Safety, Tolerability, and Pharmacokinetics in Healthy Japanese, Chinese, and White Participants., PMID:38191982
Inhibition of repulsive guidance molecule-a ameliorates compromised blood-spinal cord barrier integrity associated with neuromyelitis optica in rats., PMID:38306928
Artificial Microglia Nanoplatform Loaded With Anti-RGMa in Acoustic/Magnetic Feld for Recanalization and Neuroprotection in Acute Ischemic Stroke., PMID:39475454
Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice., PMID:39613526
The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies., PMID:39956860
Inhibition of repulsive guidance molecule A ameliorates diabetes-induced cognitive decline and hippocampal neurogenesis impairment in mice., PMID:39972167
Virus-induced RGMa expression drives neurodegeneration in HTLV-1-associated myelopathy., PMID:40305434
For research use only. Not for human or drug use.
