Catalog No.
DHG17604
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG4-Kappa
Clonality
Monoclonal
Target
Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6
Concentration
3.5mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08722
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CD47, IBI-188, CAS: 2283356-07-8
Clone ID
Letaplimab
Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity，DOI ：https://doi.org/10.1007/s00262-020-02679-5
CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus. PMID: 30643501
The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a. PMID: 32345627
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice. PMID: 30892078
A close relationship between Helicobacter pylori infection and the serum level of CD47 in adults. PMID: 32493095
Immune checkpoint CD47 molecule engineered islets mitigate instant blood-mediated inflammatory reaction and show improved engraftment following intraportal transplantation. PMID: 32342638
Hydrogen gas represses the progression of lung cancer via down-regulating CD47. PMID: 32314789
Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling. PMID: 27163531
CD47/SIRPalpha blocking enhances CD19/CD3-bispecific T cell engager antibody-mediated lysis of B cell malignancies. PMID: 30611570
Targeting the Cancer Biomarker CD47: A Review on the Diverse Mechanisms of the CD47 Pathway in Cancer Treatment. PMID: 26446381
Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells. PMID: 32948210
Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine. PMID: 33920030
Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma. PMID: 30741466
CD47 agonist peptide PKHB1 induces immunogenic cell death in T-cell acute lymphoblastic leukemia cells. PMID: 30460757
CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism. PMID: 32158445
CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer. PMID: 30525058
Peptide analogues PKHB1 and 4N1K induce cell death through CD47-independent mechanisms. PMID: 32043743
Localized CD47 blockade enhances immunotherapy for murine melanoma. PMID: 28874561
[CD47 and leukemia stem cells]. PMID: 20723335
CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis. PMID: 30539968
CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation. PMID: 28975767
The role of CD47-SIRPalpha immune checkpoint in tumor immune evasion and innate immunotherapy. PMID: 33662426
Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. PMID: 30814491
Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade. PMID: 31205227
Combination of CD47 and CD68 expression predicts survival in eastern-Asian patients with non-small cell lung cancer. PMID: 33392661
CD47 regulates the TGF-beta signaling pathway in osteoblasts and is distributed in Meckel's cartilage. PMID: 21712621
CD47 limits antibody dependent phagocytosis against non-malignant B cells. PMID: 28208074
CD47 expression in cryopreserved equine cutaneous masses and normal skin. PMID: 27154320
Role of regulatory T cells in CD47/donor-specific transfusion-induced immune tolerance in skin-heart transplantation mice. PMID: 30320937
Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation. PMID: 31628526
Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease. PMID: 24418252
Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPalpha. PMID: 31964705
CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis. PMID: 27283989
Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages. PMID: 31495971
A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions. PMID: 30449617
Tumoral and paratumoral NK cells and CD8(+) T cells of esophageal carcinoma patients express high levels of CD47. PMID: 32811852
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. PMID: 18855617
Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPalpha "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation. PMID: 33299654
CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. PMID: 27931776
MicroRNA-200a Promotes Phagocytosis of Macrophages and Suppresses Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma by Targeting CD47. PMID: 32149101
Dual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells. PMID: 30872703
CD47 augments Fas/CD95-mediated apoptosis. PMID: 15917238
Synthesis and characterization of atherosclerotic target anti-CD47 functionalized by nano-polyelectrolyte complexes between chitosan and hyaluronic acid and in vivo and in vitro targeting experiments. PMID: 33389831
Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation. PMID: 28522599
For research use only. Not for human or drug use.
