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Research Grade Motavizumab

Catalog #:   DVV02803 Specific References (100) DATASHEET
Host species: Humanized
Isotype: IgG1, kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DVV02803

Description

Motavizumab (MEDI-524, NUMAX, NISTmAb) is a second generation monoclonal antibody (mAb) derived from palivizumab (Synagis) using affinity maturation techniques. Motavizumab is currently undergoing US Food and Drug Administration review as a treatment for respiratory syncytial virus (RSV) prophylaxis. It has been evaluated in large-scale clinical studies, and has demonstrated efficacy in reducing the disease burden of RSV in high-risk infant populations.Motavizumab (MEDI-524, NUMAX, NISTmAb) has higher affinity and a longer half-life, was effective in reducing RSV hospitalization in high-risk full-term infants in the US, but was not licensed due to safety concerns (allergic reactions) .

Expression system

Mammalian Cells

Species reactivity

HRSV-A

Host species

Humanized

Isotype

IgG1, kappa

Clonality

Monoclonal

Applications

Research Grade Biosimilar

Target

F, Fusion glycoprotein F0, Fusion glycoprotein F2, p27, Intervening segment, Pep27, Peptide 27, Fusion glycoprotein F1

Concentration

3.49 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03420

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

MEDI-524,NUMAX, NISTmAb, CR9503, CAS: 677010-34-3

Clone ID

Motavizumab

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
  • SDS-PAGE
    SDS PAGE for Motavizumab
  • Bioactivity
    Detects F/Fusion glycoprotein F0 in indirect ELISAs.
  • Bioactivity
    Detects HRSV-A2 Pre-F/Fusion glycoprotein F0 Protein in indirect ELISA.
  • Bioactivity
    Detects HRSV Post-F/Fusion glycoprotein F0 Protein in indirect ELISA.
  • Bioactivity
    Detects HRSV F/Fusion glycoprotein F0 Protein in indirect ELISA.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers., PMID:21586636

Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes., PMID:21613394

A review of palivizumab and emerging therapies for respiratory syncytial virus., PMID:21831008

Epidemiology of respiratory syncytial virus infection in preterm infants., PMID:22262986

Prophylaxis and treatment of respiratory syncytial virus in adult immunocompromised patients., PMID:22395247

Characterization of neutralizing affinity-matured human respiratory syncytial virus F binding antibodies in the sub-picomolar affinity range., PMID:22407977

Testing superiority at interim analyses in a non-inferiority trial., PMID:22438208

[Anti RS virus drugs]., PMID:22568137

Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children., PMID:23633336

A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults., PMID:24080653

Motavizumab treatment of infants hospitalized with respiratory syncytial virus infection does not decrease viral load or severity of illness., PMID:24356256

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein., PMID:24725940

Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection., PMID:25070304

An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization., PMID:25269094

In silico approach towards designing virtual oligopeptides for HRSV., PMID:25525622

An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold., PMID:26434555

Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial., PMID:26511956

Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus., PMID:27070145

Motavizumab, RSV, and subsequent wheezing., PMID:27301921

Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein., PMID:27791117

Motavizumab, RSV, and subsequent wheezing - Authors' reply., PMID:27998592

Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection., PMID:28605249

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein., PMID:28894111

The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion., PMID:29212939

Two-Pore Minimum Physiologically-based Pharmacokinetic Model to Describe the Disposition of Therapeutic Monoclonal IgG Antibody in Humans., PMID:29411151

Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children., PMID:29470837

Computational redesign of human respiratory syncytial virus epitope as therapeutic peptide vaccines against pediatric pneumonia., PMID:29500665

A Minimal Physiologically Based Pharmacokinetic Model with a Nested Endosome Compartment for Novel Engineered Antibodies., PMID:29541870

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo., PMID:29553863

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen., PMID:30789898

The long road to protect infants against severe RSV lower respiratory tract illness., PMID:31105933

Immunoglobulin treatment for hospitalised infants and young children with respiratory syncytial virus infection., PMID:31446622

A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics., PMID:32697437

Pharmacological management of human respiratory syncytial virus infection., PMID:32808830

An epitope-specific chemically defined nanoparticle vaccine for respiratory syncytial virus., PMID:34145291

Adeno-Associated Virus Vector-Mediated Expression of Antirespiratory Syncytial Virus Antibody Prevents Infection in Mouse Airways., PMID:34415793

Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein., PMID:35678603

Backbone and side-chain resonance assignments of the NISTmAb-scFv and antigen-binding study., PMID:36083574

Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus in Infants and Children: A Systematic Review and Network Meta-analysis., PMID:36800182

Immunoinformatics aided approach for predicting potent cytotoxic T cell epitopes of respiratory syncytial virus., PMID:36935101

Immunoglobulin treatment for hospitalised infants and young children with respiratory syncytial virus infection., PMID:37870128

Inhaled "Muco-Trapping" Monoclonal Antibody Effectively Treats Established Respiratory Syncytial Virus (RSV) Infections., PMID:38225749

Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice., PMID:38234330

Effectiveness of nirsevimab introduction against respiratory syncytial virus in the Valencian Community: A preliminary assessment., PMID:38834430

Cost-effectiveness of RSVpreF vaccine and nirsevimab for the prevention of respiratory syncytial virus disease in Canadian infants., PMID:39079810

Systematic Review of the Efficacy and Safety of RSV-Specific Monoclonal Antibodies and Antivirals in Development., PMID:39209729

[Nirsevimab effectiveness against hospital admission for respiratory syncytial virus bronchiolitis in infants]., PMID:39308353

Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged <8 Months - United States, April 2024., PMID:39325675

The Cumulative Variations of Respiratory Syncytial Virus Fusion Protein (F) in Ten Consecutive Years in China., PMID:39452166

Impact of RSV Prevention in Infancy on Prevalence of Asthma Among 9-14-Year-old Native American Children in the Southwest United States., PMID:40208934

Respiratory syncytial virus: diagnosis, treatment and prevention, PMID: 23055894

Characterization of neutralizing affinity-matured human respiratory syncytial virus F binding antibodies in the sub-picomolar affinity range, PMID: 22407977

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein, PMID: 28894111

An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold, PMID: 26434555

A Minimal Physiologically Based Pharmacokinetic Model with a Nested Endosome Compartment for Novel Engineered Antibodies, PMID: 29541870

Adeno-Associated Virus Vector-Mediated Expression of Antirespiratory Syncytial Virus Antibody Prevents Infection in Mouse Airways, PMID: 34415793

Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children, PMID: 29470837

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen, PMID: 30789898

Monoclonal antibody for reducing the risk of respiratory syncytial virus infection in children, PMID: 23633336

Prophylaxis and treatment of respiratory syncytial virus in adult immunocompromised patients, PMID: 22395247

New strategies for control of respiratory syncytial virus infection, PMID: 18978532

Respiratory syncytial virus (RSV) prevention and treatment: past, present, and future, PMID: 19689261

Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection, PMID: 19562644

Evolution of prophylaxis: MoAb, siRNA, vaccine, and small molecules, PMID: 19651397

An epitope-specific chemically defined nanoparticle vaccine for respiratory syncytial virus, PMID: 34145291

Letter from the editor, PMID: 20065631

Respiratory syncytial virus disease: update on treatment and prevention, PMID: 21171875

Cost effectiveness of respiratory syncytial virus prophylaxis: a critical and systematic review, PMID: 20131925

In silico approach towards designing virtual oligopeptides for HRSV, PMID: 25525622

A review of palivizumab and emerging therapies for respiratory syncytial virus, PMID: 21831008

The long road to protect infants against severe RSV lower respiratory tract illness, PMID: 31105933

[Anti RS virus drugs], PMID: 22568137

Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes, PMID: 21613394

Pharmacological management of human respiratory syncytial virus infection, PMID: 32808830

Evaluation of a synthetic peptide as a replacement for the recombinant fusion protein of respiratory syncytial virus in a potency ELISA, PMID: 20943340

Computational redesign of human respiratory syncytial virus epitope as therapeutic peptide vaccines against pediatric pneumonia, PMID: 29500665

Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab, PMID: 21208913

Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection, PMID: 25070304

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract, PMID: 17362988

Safety and antiviral activity of motavizumab, a respiratory syncytial virus (RSV)-specific humanized monoclonal antibody, when administered to RSV-infected children, PMID: 19636278

A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season, PMID: 20525274

Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus, PMID: 21549714

Structural basis of respiratory syncytial virus neutralization by motavizumab, PMID: 20098425

Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection, PMID: 28605249

Safety, tolerability, pharmacokinetics, and immunogenicity of motavizumab, a humanized, enhanced-potency monoclonal antibody for the prevention of respiratory syncytial virus infection in at-risk children, PMID: 19258920

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn), PMID: 16793771

A randomized controlled trial of motavizumab versus palivizumab for the prophylaxis of serious respiratory syncytial virus disease in children with hemodynamically significant congenital heart disease, PMID: 21522037

A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults, PMID: 24080653

Respiratory syncytial virus-neutralizing monoclonal antibodies motavizumab and palivizumab inhibit fusion, PMID: 20519399

Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial, PMID: 26511956

Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab, PMID: 17990791

Motavizumab, a neutralizing anti-Respiratory Syncytial Virus (Rsv) monoclonal antibody significantly modifies the local and systemic cytokine responses induced by Rsv in the mouse model, PMID: 17961258

Motavizumab, a second-generation humanized mAb for the prevention of respiratory syncytial virus infection in high-risk populations, PMID: 19330726

Motavizumab treatment of infants hospitalized with respiratory syncytial virus infection does not decrease viral load or severity of illness, PMID: 24356256

Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo, PMID: 29553863

Motavizumab for prophylaxis of respiratory syncytial virus in high-risk children: a noninferiority trial, PMID: 20008423

Motavizumab, RSV, and subsequent wheezing - Authors' reply, PMID: 27998592

Motavizumab, RSV, and subsequent wheezing, PMID: 27301921

Motavizumab for the prevention of respiratory syncytial virus infection in infants, PMID: 19764889

Motavizumab, PMID: 20065632

Datasheet

Document Download

Research Grade Motavizumab.pdf

 

$ 530
Product specifications
1 mg 530 5 mg 1590 25 mg 4130

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Research Grade Motavizumab [DVV02803]
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