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Research Grade Dostarlimab

Catalog #:   DHH02205 Specific References (67) DATASHEET
Host species: Humanized
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHH02205

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

Concentration

7.98 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q15116

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

100 mM Pro-Ac, 20 mM Arg, pH 5.0

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

ANB-011, TSR-042, CAS: 2022215-59-2

Clone ID

Dostarlimab

Data Image
  • Bioactivity
    Detects Human CD279/PDCD1/PD1 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Dostarlimab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Clinical Activity and Safety of the Anti-Programmed Death 1 Monoclonal Antibody Dostarlimab for Patients With Recurrent or Advanced Mismatch Repair-Deficient Endometrial Cancer: A Nonrandomized Phase 1 Clinical Trial, PMID: 33001143

Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer, PMID: 33251877

Antibodies to watch in 2020, PMID: 31847708

Dostarlimab-gxly, PMID: 34136921

Dostarlimab: First Approval, PMID: 34106455

A Prospective Phase II Single-arm Study of Niraparib Plus Dostarlimab in Patients With Advanced Non-small-cell Lung Cancer and/or Malignant Pleural Mesothelioma, Positive for PD-L1 Expression and Germline or Somatic Mutations in the DNA Repair Genes: Rationale and Study Design, PMID: 32917522

Dostarlimab, PMID: 34014626

A Review of Immune Checkpoint Blockade Therapy in Endometrial Cancer, PMID: 32213091

An Integrated Analysis of Dostarlimab Immunogenicity, PMID: 34324079

Dostarlimab for the treatment of endometrium cancer and other solid tumors, PMID: 33729216

Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models, PMID: 34313545

[New drug approval: Dostarlimab - second line in advanced MSI endometrial cancer], PMID: 33994164

Clinical activity and safety of the anti-PD-1 monoclonal antibody dostarlimab for patients with recurrent or advanced dMMR endometrial cancer, PMID: 34427115

18 F-FDG PET/CT in Relapsed Endometrial Cancer Treated with Preoperative PD-1 Inhibitor Dostarlimab, PMID: 34441288

Endometrial Carcinoma: Immune Microenvironment and Emerging Treatments in Immuno-Oncology, PMID: 34199461

[MSI testing : What is new? What should be considered? German version], PMID: 34043067

Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design, PMID: 33682447

Erratum to 'Phase 2b, open-label, single-arm, multicenter pilot study of the efficacy, safety, and tolerability of dostarlimab in women with early-stage mismatch repair-deficient endometrioid endometrial adenocarcinoma' [International Journal of Gynecological Cancer Volume 35 Issue 4 (2025) 101644]., PMID:40506308

Cost-effectiveness of chemotherapy in advanced and recurrent endometrial cancer., PMID:40487854

Dostarlimab and niraparib in primary advanced ovarian cancer., PMID:40461381

Interview with the World Class Authorities Frontiers of Cancer Research: An exclusive interview with Professor Luis Diaz., PMID:40385346

An ambispective, real-world multi-center study of DOstarlimab in patients with Recurrent or Advanced DNA mismatch repair deficient/microsatellite instability-high endometrial cancer (GEICO 120-R/DORA study)., PMID:40382973

Phase II Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma., PMID:40377969

[Pembrolizumab or dostarlimab in association to chemotherapy in advanced endometrial cancer]., PMID:40348649

Extended neoadjuvant dostarlimab provides durable benefit in resectable dMMR solid tumours., PMID:40335758

DOMENICA: dostarlimab versus chemotherapy alone in first-line MMR-deficient advanced endometrial cancer patients., PMID:40323277

Rectal stenosis after immunotherapy in a mismatch repair deficient rectal cancer. Case report and review of literature., PMID:40308628

Intratumoral Heterogeneity of Mismatch Repair Status and Outcome of Treatment With Dostarlimab in a Patient With Locally Advanced Rectal Adenocarcinoma., PMID:40294354

Nonoperative Management of Mismatch Repair-Deficient Tumors., PMID:40293177

Immune checkpoint Inhibitor-Induced Autoimmune hemolytic anemia in endometrial cancer., PMID:40292083

Pharmacovigilance study on the reporting frequency of atrial fibrillation with immune checkpoint inhibitors: insights from FDA Adverse Event Reporting System., PMID:40290514

Screening and prevention of gynecologic malignancies in patients with lynch syndrome: following the guidelines., PMID:40144212

A Phase Two, Single-Arm, Open-Label Study With Dostarlimab Monotherapy in Participants With Untreated Stage II/III dMMR/MSI-H Locally Advanced Rectal Cancer (AZUR-1)., PMID:40107952

Molecular Testing and Targeted Therapies in Hepatobiliary Cancers: A Review., PMID:40105823

Releasing the brakes: the role of immune checkpoint inhibitors in laryngeal cancer., PMID:40061133

CITRINO: phase 1 dose escalation study of anti-LAG-3 antibody encelimab alone or in combination with anti-PD-1 dostarlimab in patients with advanced/metastatic solid tumours., PMID:40016550

Phase 2b, open-label, single-arm, multicenter pilot study of the efficacy, safety, and tolerability of dostarlimab in women with early-stage mismatch repair-deficient endometrioid endometrial adenocarcinoma., PMID:39955187

Clinical Use of Dostarlimab in Advanced Stage and Recurrent Endometrial Cancer: Patient Selection and Perspectives., PMID:39881947

Treatment strategies for advanced and recurrent endometrial cancer using immune checkpoint inhibitors., PMID:39812928

Phase II randomized study of dostarlimab alone or with bevacizumab versus non-platinum chemotherapy in recurrent gynecological clear cell carcinoma (DOVE/APGOT-OV7/ENGOT-ov80)., PMID:39710508

Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy., PMID:39690423

If it is a solid tumor target, then it may be a hematologic cancer target: Bridging the great divide., PMID:39689708

The Role of Immunotherapy in MMR-Deficient Endometrial Carcinoma: State of the Art and Future Perspectives., PMID:39685500

Advances in Immunotherapy for Endometrial Cancer: Insights into MMR Status and Tumor Microenvironment., PMID:39682106

Cardiotoxicity associated with immune checkpoint inhibitors: Systematic review and meta-analysis., PMID:39667715

Efficacy and safety of dostarlimab in combination with chemotherapy in patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer in a phase 3, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY)., PMID:39531903

Cost-effectiveness of dostarlimab plus carboplatin-paclitaxel for primary advanced or recurrent endometrial cancer from a US payer perspective., PMID:39520771

Population pharmacokinetics and exposure-response relationships of dostarlimab in primary advanced or recurrent endometrial cancer in part 1 of RUBY., PMID:39520048

Histology Agnostic Drug Development: An Updated Review., PMID:39518080

Immune Checkpoint Inhibitor Myopathy: The Double-Edged Sword of Cancer Immunotherapy., PMID:39514829

Redefining pancreatic cancer management with tumor-agnostic precision medicine., PMID:39514550

[Practice-changing clinical trials in gastrointestinal radiation oncology]., PMID:39426846

Dostarlimab A new hope for endometrial cancer patients in Pakistan., PMID:39407404

Patient-reported outcomes in patients with metastatic non-squamous non-small cell lung cancer from the randomized Phase II PERLA trial comparing first-line chemotherapy plus dostarlimab or pembrolizumab., PMID:39378565

Curative immune checkpoint inhibitors therapy in patients with mismatch repair-deficient locally advanced rectal cancer: a real-world observational study., PMID:39357124

Safety of dostarlimab in combination with chemotherapy in patients with primary advanced or recurrent endometrial cancer in a phase III, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY)., PMID:39346117

Secondary Hemophagocytic Lymphohistiocytosis Following Dostarlimab Treatment in a Patient With Metastatic Endometrial Cancer., PMID:39328329

Patient-reported outcomes in the subpopulation of patients with mismatch repair-deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer treated with dostarlimab plus chemotherapy compared with chemotherapy alone in the ENGOT-EN6-NSGO/GOG3031/RUBY trial., PMID:39322611

Guidelines of Onkopedia: What Is New? Locally Advanced Rectal Cancer., PMID:39288743

Bilateral Panuveitis After Endometrial Cancer Treatment with Dostarlimab: A Case Report., PMID:39284117

Budget impact of dostarlimab plus carboplatin-paclitaxel for primary advanced or recurrent endometrial cancer from a third-party US payer perspective., PMID:39254489

Psoriasis and psoriatic arthritis following use of dostarlimab for endometrial cancer., PMID:39097324

Target-Driven Tissue-Agnostic Drug Approvals-A New Path of Drug Development., PMID:39061168

Dostarlimab: A promising new PD-1 inhibitor for cancer immunotherapy., PMID:39056234

Adverse Events of PD-1, PD-L1, CTLA-4, and LAG-3 Immune Checkpoint Inhibitors: An Analysis of the FDA Adverse Events Database., PMID:39051335

The evolving role of immune checkpoint inhibitors in cervical and endometrial cancer., PMID:39050882

Dostarlimab in the treatment of mismatch repair deficient recurrent or advanced endometrial cancer., PMID:39027143

Datasheet

Document Download

Research Grade Dostarlimab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Dostarlimab [DHH02205]
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