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Research Grade Tafasitamab

Catalog #:   DHD10803 Specific References (71) DATASHEET
Host species: Humanized
Isotype: IgG1-G2-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD10803

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-G2-kappa

Clonality

Monoclonal

Target

CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4

Concentration

6.03 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15391

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CD19, MOR-00208, MOR-208, XENP-5574, XMP-5574, XmAb-5574, Xmab-CD19, CAS: 1422527-84-1

Clone ID

Tafasitamab

Note

For research use only. Not suitable for clinical or therapeutic use.

Data Image
  • SDS-PAGE
    SDS PAGE for Tafasitamab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
  • Flow Cytometry
    Figure 3. Binding specificity and cell-cell linkage induced by biHSNPs. Target cells were incubated with FITC-labeled, antibody-coated HSNPs at 4 ℃ for 30 min, followed by flow cytometry analysis to confirm binding specificity D) Verification of biHSNPs binding to CD3+ cells using PBMCs as the CD3+ cell line. E) Verification of biHSNPs binding to CD19+/CD20+ cells using Raji cells as the target. F)Verification of biHSNPs binding to CD16+ cells using PBMCs as the CD16+ cell line. G) Verification of biHSNPs binding to CD19+/CD20+ cells usingRaji cells as the target. Figure S6. FACS binding results of HSNPαCD3, HSNPαCD19, HSNPαCD20, HSNPαCD3+αCD19 and HSNPαCD3+αCD20 with Jurkat cells as CD3+ cell lines.
    Data sourced from citation (PMID: 40789685)
References

Bispecific Nanosystems Enable Multieffector Immune Cell Retargeting for Hematologic Malignancy Therapy. [DHD10803]

Drug-Resistance Mechanism and New Targeted Drugs and Treatments of Relapse and Refractory DLBCL., PMID:36873252

Efficacy of Salvage Treatments in Relapsed or Refractory Diffuse Large B-Cell Lymphoma Including Chimeric Antigen Receptor T-Cell Therapy: A Systematic Review and Meta-Analysis., PMID:36915243

RE-MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola-BR), CAR-T therapies, and lenalidomide/rituximab (R2) based on real-world data in patients with relapsed/refractory diffuse large B-cell lymphoma., PMID:37171597

SEOM-GOTEL clinical guidelines on diffuse large B cell lymphoma (2022)., PMID:37289353

Novel agents in relapsed/refractory diffuse large B-cell lymphoma., PMID:37294966

Epcoritamab (Epkinly) for diffuse large B-cell lymphoma (DLBCL)., PMID:37339097

Safety and efficacy of tafasitamab with or without lenalidomide added to first-line R-CHOP for DLBCL: the phase 1b First-MIND study., PMID:37369099

Correction to: RE‑MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola‑BR), CAR‑T therapies, and lenalidomide/rituximab (R2) based on real‑world data in patients with relapsed/refractory diffuse large B‑cell lymphoma., PMID:37432417

New treatment options in elderly patients with Diffuse Large B-cell Lymphoma., PMID:37465115

Targeted Treatment of Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL): Tafasitamab in Context., PMID:37492075

In brief: Tafasitamab (Monjuvi) for diffuse large B-cell., PMID:37516901

Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma., PMID:37600821

Cost-effectiveness analysis of transplant-ineligible relapsed or refractory diffuse large B-cell lymphoma treatment options-Experience of the efficiency frontier approach., PMID:37644352

Tafasitamab for patients with relapsed or refractory diffuse large B-cell lymphoma: final 5-year efficacy and safety findings in the phase II L-MIND study., PMID:37646664

Pityriasis lichenoides chronica in a patient on tafasitamab and lenalidomide therapy for diffuse large B-cell lymphoma., PMID:37701883

Tafasitamab and lenalidomide in large B-cell lymphoma: real-world outcomes in a multicenter retrospective study., PMID:37738563

A new frontier for R-CHOP: is two better than one?, PMID:37856095

CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS., PMID:37879074

Preclinical study of CD19 detection methods post tafasitamab treatment., PMID:37928552

Efficacy of CD19 directed therapies in patients with relapsed or refractory large b-cell lymphoma relapsing after CD19 directed chimeric antigen receptor T-cell therapy., PMID:37973893

Developing New Strategies for Relapsed/Refractory Diffuse Large B-Cell Lymphoma., PMID:38068428

Tribulations of trials in aggressive lymphoma., PMID:38153771

Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma: New Approved Options., PMID:38202077

CD19 occupancy may drive CARs further., PMID:38236611

An Expedition on Synthetic Methodology of FDA-approved Anticancer Drugs (2018-2021)., PMID:38288815

Tafasitamab for the treatment of patients with diffuse large B-cell lymphoma., PMID:38299612

Second-line treatment of diffuse large B-cell lymphoma: Evolution of options., PMID:38342663

Flow cytometry interference in patients treated with tafasitamab: Unraveling the diagnostic maze., PMID:38434528

Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts., PMID:38610966

Sequencing of Anti-CD19 Therapies in the Management of Diffuse Large B-Cell Lymphoma., PMID:38661647

Time-dependent cost comparison and health economic impact analysis of second-line interventions for transplant-ineligible patients with relapsed or refractory diffuse large B cell lymphoma., PMID:38853698

Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab., PMID:38934068

Real-world outcomes with novel therapies in relapsed/refractory diffuse large B-cell lymphoma., PMID:39011744

Comparisons of treatment outcomes of epcoritamab versus chemoimmunotherapy, polatuzumab-based regimens, tafasitamab-based regimens, or chimeric antigen receptor T-cell therapy, in third-line or later relapsed/refractory large B-cell lymphoma., PMID:39152509

Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy., PMID:39163620

How I treat older patients with relapsed/refractory diffuse large B-cell lymphoma., PMID:39356892

Sakemura RL, Manriquez Roman C, Horvei P, et al. CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS. Blood. 2024;143(3):258-271., PMID:39361306

A real-world pharmacovigilance study of tafasitamab: data mining of the US food and drug administration adverse event reporting system., PMID:39425497

SOHO State of the Art Updates and Next Questions | Diffuse Large B-Cell Lymphoma in Older Adults: A Comprehensive Review., PMID:39613700

Real-world use of tafasitamab preceding CD19-directed chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma., PMID:39849596

Tafasitamab in refractory diffuse large B-cell lymphoma with neurolymphomatosis., PMID:39934427

Real-World Effectiveness of Chemoimmunotherapy and Novel Therapies for Patients With Relapsed/Refractory Aggressive Large B-Cell Lymphoma., PMID:39966020

Highlights from the 66th ASH Annual Meeting 2024., PMID:39970879

Budget impact of introducing glofitamab for treatment of relapsed or refractory diffuse large B-cell lymphoma after two or more lines of systemic therapy in the United States., PMID:40163049

Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway., PMID:40175588

Clinical benefit of tafasitamab plus lenalidomide in relapsed or refractory diffuse large Bcell lymphoma: real-world data from the EarlyMIND study., PMID:40371897

Heavily Pretreated Refractory Diffuse Large B-Cell Lymphoma Successfully Treated with Epcoritamab: Case Report., PMID:40524964

Single-agent MOR208 salvage and maintenance therapy in a patient with refractory/relapsing diffuse large B-cell lymphoma: a case report, PMID: 27178351

The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients, PMID: 23277329

Incorporating Novel Targeted and Immunotherapeutic Agents in Treatment of B-Cell Lymphomas, PMID: 33770460

Lenalidomide in DLBCL: are we past the cell of origin?, PMID: 33989279

Diffuse large B-cell lymphoma: new targets and novel therapies, PMID: 33820908

Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering, PMID: 33212776

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma, PMID: 34407608

Anti-CD19 CAR T-cell therapy remission despite prior anti-CD19 antibody Tafasitamab in relapsed/refractory DLBCL, PMID: 34354920

Long-term outcomes from the Phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma, PMID: 34196165

RE-MIND: Comparing tafasitamab + lenalidomide (L-MIND) with a real‑world lenalidomide monotherapy cohort in relapsed or refractory diffuse large B-cell lymphoma, PMID: 34433649

A phase 2a, single-arm, open-label study of tafasitamab, a humanized, Fc-modified, anti-CD19 antibody, in patients with relapsed/refractory B-precursor cell acute lymphoblastic leukemia, PMID: 34343354

Diffuse Large B-cell Lymphoma Responds to Tafasitamab plus Lenalidomide, PMID: 34376434

Tafasitamab combined with idelalisib or venetoclax in patients with CLL previously treated with a BTK inhibitor, PMID: 34414843

Tafasitamab for the treatment of relapsed or refractory diffuse large B-cell lymphoma, PMID: 33554668

Phase IIa study of the CD19 antibody MOR208 in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma, PMID: 29444231

The use of tafasitamab in diffuse large B-cell lymphoma, PMID: 34285786

Challenges and Opportunities in the Management of Diffuse Large B-Cell Lymphoma in Older Patients, PMID: 33230948

Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma, PMID: 33202794

Antibodies to watch in 2020, PMID: 31847708

Tafasitamab, PMID: 33355731

Tafasitamab-cxix, PMID: 33016999

Tafasitamab: First Approval, PMID: 32946059

Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study, PMID: 32511983

Datasheet

Document Download

Research Grade Tafasitamab.pdf

 

$ 800
Product specifications
1 mg 800 5 mg 2240 25 mg 5820

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Research Grade Tafasitamab [DHD10803]
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