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Research Grade Bamlanivimab

Catalog #:   DVV00303 Specific References (98) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DVV00303

Expression system

Mammalian Cells

Species reactivity

SARS-CoV-2 (2019-nCoV)

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Spike glycoprotein, S glycoprotein, E2, Peplomer protein, Spike protein S1, Spike protein S2, Spike protein S2', S, 2

Concentration

1.07 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P0DTC2

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

LY-3819253, LY-CoV555, LY3819253, CAS: 2423943-37-5

Clone ID

Bamlanivimab

Data Image
  • SDS-PAGE
    SDS PAGE for Bamlanivimab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial, PMID: 33475701

Bamlanivimab, PMID: 33226744

An EUA for Bamlanivimab-A Monoclonal Antibody for COVID-19, PMID: 33306087

Covid-19: FDA authorises neutralising antibody bamlanivimab for non-admitted patients, PMID: 33177042

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19, PMID: 33113295

Antimicrobial stewardship and bamlanivimab: Opportunities for outpatient preauthorization?, PMID: 33213544

COVID-19 vaccines: The status and perspectives in delivery points of view, PMID: 33359141

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline, PMID: 33319649

Antibodies to watch in 2021, PMID: 33459118

An EUA for bamlanivimab - a monoclonal antibody for COVID-19, PMID: 33443490

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19, PMID: 33356051

Bamlanivimab for Prevention of COVID-19, PMID: 34081075

Bamlanivimab Use in a Military Treatment Facility, PMID: 33993281

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19, PMID: 34260849

Expanded Access Programs, compassionate drug use, and Emergency Use Authorizations during the COVID-19 pandemic, PMID: 33253920

Efficacy of Bamlanivimab in Reducing Hospitalization and Mortality Rates in COVID-19 Patients in a Rural Community, PMID: 34430093

Etesevimab and Bamlanivimab, PMID: 33630482

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial, PMID: 34081073

A Narrative Review of the Clinical Practicalities of Bamlanivimab and Etesevimab Antibody Therapies for SARS-CoV-2, PMID: 34374951

Real-World Experience of Bamlanivimab for COVID-19: A Case-Control Study, PMID: 33846730

Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of Coronavirus Disease 2019 in Children and Adolescents, PMID: 33388760

Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19, PMID: 34411003

An EUA for bamlanivimab and etesevimab for COVID-19, PMID: 33830966

Bamlanivimab as monotherapy in two immunocompromised patients with COVID-19, PMID: 34341781

Impact of Bamlanivimab Monoclonal Antibody Treatment on Hospitalization and Mortality Among Nonhospitalized Adults With Severe Acute Respiratory Syndrome Coronavirus 2 Infection, PMID: 34250192

Bamlanivimab For Mild to Moderate COVID-19 in Kidney Transplant Recipients, PMID: 34222731

Association of Intravenous Bamlanivimab Use with Reduced Hospitalization, Intensive Care Unit Admission, and Mortality in Patients with Mild to Moderate COVID-19, PMID: 34075387

Bamlanivimab infusion experience at one academic emergency department, PMID: 34294501

Bamlanivimab use in mild-to-moderate COVID-19 disease: A matched cohort design, PMID: 34328670

Diffuse C4d staining of peritubular capillaries in renal allograft following bamlanivimab therapy, PMID: 34358400

Etesevimab, PMID: 34283469

First in Human Study of Bamlanivimab in a Randomized Trial of Hospitalized Patients with COVID-19, PMID: 34455583

Initial experience of bamlanivimab monotherapy use in solid organ transplant recipients, PMID: 34081820

Bamlanivimab for treatment of COVID-19 in solid organ transplant recipients: Early single-center experience, PMID: 33595145

Efficacy of Bamlanivimab/Etesevimab and Casirivimab/Imdevimab in Preventing Progression to Severe COVID-19 and Role of Variants of Concern, PMID: 34435337

Emergence of the E484K mutation in SARS-COV-2-infected immunocompromised patients treated with bamlanivimab in Germany, PMID: 34278371

Bamlanivimab treatment leads to rapid selection of immune escape variant carrying E484K mutation in a B.1.1.7 infected and immunosuppressed patient, PMID: 34009286

The Efficacy of Bamlanivimab in Reducing Emergency Department Visits and Hospitalizations in a Real-world Setting, PMID: 34258324

Consequences of rush to emergency use authorization of bamlanivimab, PMID: 34216205

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro, PMID: 33619479

Emergency Use Authorization for Bamlanivimab in Mild to Moderate COVID-19: Implications for CNS Practice, PMID: 33793179

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro, PMID: 34074219

Administration of Bamlanivimab to Skilled Nursing Facility Residents During a COVID-19 Outbreak, January-February 2021, Arizona, PMID: 34000267

Emergency Use Authorization for Bamlanivimab in Mild to Moderate COVID-19: Implications for Clinical Nurse Specialist Practice, PMID: 33793172

Real-World Clinical Outcomes of Bamlanivimab and Casirivimab-Imdevimab among High-Risk Patients with Mild to Moderate Coronavirus Disease 2019, PMID: 34279629

An overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future, PMID: 34304682

Emergence of E484K Mutation Following Bamlanivimab Monotherapy among High-Risk Patients Infected with the Alpha Variant of SARS-CoV-2, PMID: 34452507

Clinical Impact of the Early Use of Monoclonal Antibody LY-CoV555 (Bamlanivimab) on Mortality and Hospitalization Among Elderly Nursing Home Patients: A Multicenter Retrospective Study, PMID: 33981518

Emergence of Q493R mutation in SARS-CoV-2 spike protein during bamlanivimab/etesevimab treatment and resistance to viral clearance, PMID: 34437928

SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination, PMID: 34270919

The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cells., PMID:40434113

Effectiveness of Anti-SARS-CoV-2 monoclonal antibodies in real-life: RNAemia and clinical outcomes in high-risk COVID-19 patients., PMID:40279347

Regional comparison of efficacy and safety for vilobelimab in critically ill, invasively mechanically ventilated COVID-19 patients., PMID:40250846

Monoclonal Antibodies in Prevention and Early Treatment of COVID-19 in Lung Transplant Recipients: A Systematic Review and Perspective on the Role of Monoclonal Antibodies in the Future., PMID:39995815

Innate and SARS-CoV-2 specific adaptive immune response kinetic in neutralizing monoclonal antibody successfully treated COVID-19 patients., PMID:39832460

An evaluation of vilobelimab (anti-C5a) as a cost-effective option to treat severely ill mechanically ventilated patients with COVID-19., PMID:39475087

Comparison of Dual Monoclonal Antibody Therapies for COVID-19 Evolution: A Multicentric Retrospective Study., PMID:39459877

Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection., PMID:39405332

Adverse events associated with SARS-CoV-2 neutralizing monoclonal antibodies using the FDA adverse event reporting system database., PMID:39345748

Identification of antibody-resistant SARS-CoV-2 mutants via N4-Hydroxycytidine mutagenesis., PMID:39293594

Impact analysis of SARS-CoV-2 vaccination in patients treated with monoclonal antibodies: A monocentric experience., PMID:39265354

Impact of SARS-CoV-2 Resistance to Antiviral Monoclonal Antibody Therapy on Neutralizing Antibody Response., PMID:39247686

Monoclonal antibodies against SARS-CoV-2 to prevent COVID-19 worsening in a large multicenter cohort., PMID:39247344

Efficacy and Safety of Low-Dose, Rapidly Infused Bamlanivimab and Etesevimab: Phase 3 BLAZE-1 Trial for Mild-to-Moderate COVID-19., PMID:39230829

Comparison Study of the Bio-Plex and Meso Scale Multiplexed SARS-CoV-2 Serology Assays Reveals Evidence of Diminished Host Antibody Responses to SARS-CoV-2 after Monoclonal Antibody Treatment., PMID:39165724

Monoclonal Antibody Therapies Against SARS-CoV-2: Promises and Realities., PMID:39126484

Effective Treatment of COVID-19 Infection with Repurposed Drugs: Case Reports., PMID:39096169

Longitudinal importance of the soluble receptor for advanced glycation end-products in nonintubated hospitalized patients with COVID-19 pneumonia., PMID:39076084

Clinical outcomes in patients with mild to moderate coronavirus disease 2019 treated with monoclonal antibody therapy versus an untreated control cohort., PMID:39066463

SARS-CoV-2 Monoclonal Antibody Treatment Followed by Vaccination Shifts Human Memory B-Cell Epitope Recognition, Suggesting Antibody Feedback., PMID:39036987

Sotrovimab in the treatment of coronavirus disease-2019 (COVID-19): a systematic review and meta-analysis of randomized clinical trials., PMID:39031183

Safety and Efficacy of SAB-185 for Nonhospitalized Adults With COVID-19: A Randomized Clinical Trial., PMID:39028902

Real-world effectiveness of sotrovimab in preventing hospitalization and mortality in high-risk patients with COVID-19 in the United States: A cohort study from the Mayo Clinic electronic health records., PMID:39012863

Repurposing of therapeutic antibodies against dengue virus envelope protein receptor binding domain., PMID:38900285

Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study., PMID:38815595

Comparison of bamlanivimab with or without etesevimab and casirivimab-imdevimab in clinical outcomes in patients with COVID-19: a systematic review and meta-analysis., PMID:38721976

Viral Kinetics Model of SARS-CoV-2 Infection Informs Drug Discovery, Clinical Dose, and Regimen Selection., PMID:38676291

Efficacy and safety of bamlanivimab in patients with COVID-19: A systematic review and meta-analysis., PMID:38616851

Failure of bamlanivimab with selection of E484K mutation in an allogeneic stem cell transplant recipient with nosocomial SARS-CoV-2 infection., PMID:38353416

Effect of Bamlanivimab as Monotherapy or in Combination with Etesevimab or Sotrovimab on Persistently High Viral Load in Patients with Mild-to-Moderate COVID-19: A Randomized, Phase 2 BLAZE-4 Trial., PMID:38291279

Developing of SARS-CoV-2 fusion protein expressed in E. coli Shuffle T7 for enhanced ELISA detection sensitivity - an integrated experimental and bioinformatic approach., PMID:38234051

The Therapeutic Monoclonal Antibody Bamlanivimab Does Not Enhance SARS-CoV-2 Infection by FcR-Mediated Mechanisms., PMID:38133292

Randomized trial of the safety and efficacy of anti-SARS-CoV-2 mAb in the treatment of patients with nosocomial COVID-19 (CATCO-NOS)., PMID:38058498

SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback., PMID:38045374

Impaired immune responses and prolonged viral replication in lung allograft recipients infected with SARS-CoV-2 in the early phase after transplantation., PMID:37922037

The Efficacy and Safety of Monoclonal Antibody Treatments Against COVID-19: A Systematic Review and Meta-analysis of Randomized Clinical Trials., PMID:37915159

Assessment of neutralization susceptibility of Omicron subvariants XBB.1.5 and BQ.1.1 against broad-spectrum neutralizing antibodies through epitopes mapping., PMID:37828918

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody., PMID:37745410

Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review., PMID:37719798

Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual., PMID:37692895

A Comparison of the Adverse Effects and Utility of Different Monoclonal Antibodies for SARS-CoV-2: A Retrospective Cohort Study., PMID:37680398

Long COVID After Bamlanivimab Treatment., PMID:37650236

Use of Monoclonal Antibodies in Pregnant Women Infected by COVID-19: A Case Series., PMID:37630512

Clinical Features and Risk Stratification of Multiple Myeloma Patients with COVID-19., PMID:37509261

Preliminary Evidence of Good Safety Profile and Outcomes of Early Treatment with Tixagevimab/Cilgavimab Compared to Previously Employed Monoclonal Antibodies for COVID-19 in Immunocompromised Patients., PMID:37371635

Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial., PMID:37329415

Neutralizing anti-spike monoclonal antibodies for COVID-19 in vulnerable populations: lessons learned and future directions., PMID:37318043

Outcomes of Bebtelovimab Therapy in Patients With Solid Organ Transplantation With Mild and Moderate COVID-19., PMID:37313067

Datasheet

Document Download

Research Grade Bamlanivimab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Bamlanivimab [DVV00303]
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