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Research Grade Inebilizumab

Catalog #:   DHD10802 Specific References (98) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD10802

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4

Concentration

1.31 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15391

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CD19, MEDI-551, CAS: 1299440-37-1

Clone ID

Inebilizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Inebilizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Inebilizumab: First Approval, PMID: 32729016

Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial, PMID: 31495497

Inebilizumab-cdon, PMID: 32936251

Antibodies to watch in 2020, PMID: 31847708

Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder, PMID: 33223088

Inebilizumab, a B Cell-Depleting Anti-CD19 Antibody for the Treatment of Autoimmune Neurological Diseases: Insights from Preclinical Studies, PMID: 27886126

New therapies for neuromyelitis optica spectrum disorder, PMID: 33186537

Inebilizumab in AQP4-Ab-positive neuromyelitis optica spectrum disorder, PMID: 34061127

Targeting B cells to modify MS, NMOSD, and MOGAD: Part 2, PMID: 33411674

Recent progress in maintenance treatment of neuromyelitis optica spectrum disorder, PMID: 33011853

Targeting B Cells to Modify MS, NMOSD, and MOGAD: Part 1, PMID: 33406479

Review of approved NMO therapies based on mechanism of action, efficacy and long-term effects, PMID: 33059216

Update on neuromyelitis optica spectrum disorder, PMID: 33009077

Immunotherapy in myasthenia gravis in the era of biologics, PMID: 30573759

Emerging drugs for the treatment of neuromyelitis optica, PMID: 32731771

ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52), PMID: 29447988

Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody, PMID: 30575890

A multicenter phase I study of inebilizumab, a humanized anti-CD19 monoclonal antibody, in Japanese patients with relapsed or refractory B-cell lymphoma and multiple myeloma, PMID: 30915717

Novel insights into pathophysiology and therapeutic possibilities reveal further differences between AQP4-IgG- and MOG-IgG-associated diseases, PMID: 32304439

Safety and tolerability of inebilizumab (MEDI-551), an anti-CD19 monoclonal antibody, in patients with relapsing forms of multiple sclerosis: Results from a phase 1 randomised, placebo-controlled, escalating intravenous and subcutaneous dose study, PMID: 29143550

Brainstem and cerebellar involvement in MOG-IgG-associated disorder versus aquaporin-4-IgG and MS, PMID: 33372052

Inebilizumab-cdon: USFDA approval for the treatment of NMOSD (neuromyelitis optica spectrum disorder), PMID: 34011260

Baseline Plasma Cell Gene Signature Predicts Improvement in Systemic Sclerosis Skin Scores Following Treatment With Inebilizumab (MEDI-551) and Correlates With Disease Activity in Systemic Lupus Erythematosus and Chronic Obstructive Pulmonary Disease, PMID: 29956883

Disability Outcomes in the N-MOmentum Trial of Inebilizumab in Neuromyelitis Optica Spectrum Disorder, PMID: 33771837

Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD, PMID: 33538237

Emerging Targeted Therapies for Neuromyelitis Optica Spectrum Disorders, PMID: 33301078

Current and emerging biologics for the treatment of neuromyelitis optica spectrum disorders, PMID: 32228250

B cells in multiple sclerosis therapy-A comprehensive review, PMID: 29512131

Immune reconstitution therapy in NMOSD, PMID: 33992916

Lupus and NMOSD: The Blending of Humoral Autoimmunity, PMID: 33123402

Satralizumab in the treatment of neuromyelitis optica spectrum disorder, PMID: 33167776

Efficiency of antibody therapy in demyelinating diseases, PMID: 28910968

Investigational drugs in development to prevent neuromyelitis optica relapses, PMID: 29465257

Long-term Outcomes in Patients With Myelin Oligodendrocyte Glycoprotein Immunoglobulin G-Associated Disorder, PMID: 32865549

Efficacy and Safety of Monoclonal Antibody Therapy in Neuromyelitis Optica Spectrum Disorders: Evidence from Randomized Controlled Trials, PMID: 32442886

New Therapeutic Landscape in Neuromyelitis Optica, PMID: 33814893

Coexistence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies in Adult and Pediatric Patients, PMID: 31657826

B Cells and Antibodies as Targets of Therapeutic Intervention in Neuromyelitis Optica Spectrum Disorders, PMID: 33419217

[Neuromyelitis Optica Spectrum Disorder], PMID: 34006678

Recent advances in the treatment of neuromyelitis optica spectrum disorders, PMID: 33741809

Application of 2015 Seronegative Neuromyelitis Optica Spectrum Disorder Diagnostic Criteria for Patients With Myelin Oligodendrocyte Glycoprotein IgG-Associated Disorders, PMID: 32777005

Seroprevalence and clinical phenotype of MOG-IgG-associated disorders in Sri Lanka, PMID: 31387865

Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?, PMID: 33777853

Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics, PMID: 33909234

Rituximab for the Treatment of Neuromyelitis Optica Spectrum Disorder [Internet], PMID: 34165925

Clinical Utility of Antiretinal Antibody Testing, PMID: 33885761

Clinical spectrum of high-titre GAD65 antibodies, PMID: 33563803

A lifetime aging study of human CD19 transgenic mice, PMID: 28243835

Serum Glial Fibrillary Acidic Protein: A Neuromyelitis Optica Spectrum Disorder Biomarker, PMID: 33724534

The frequency of longitudinally extensive transverse myelitis in MS: A population-based study, PMID: 31707235

Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders., PMID:40506618

An updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote., PMID:40472799

Relapses during treatment with monoclonal antibodies targeting B-cells in NMOSD., PMID:40383834

Clinical Features and Factors Associated With Outcome in Late Adult-Onset Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease., PMID:40324120

Utility of spinal cord axial-T2 sequence in a population-based cohort of multiple sclerosis., PMID:40301133

Neuromyelitis optica spectrum disorder in Latin America: a global data share initiative., PMID:40267692

A Phase 3 Trial of Inebilizumab in Generalized Myasthenia Gravis., PMID:40202593

Satralizumab after inebilizumab treatment in a patient with recurrent neuromyelitis optica spectrum disorder: A case report., PMID:40193676

Management of IgG4-related cholangitis: diagnosis, therapy, and long-term surveillance., PMID:40191403

The Evolution of Anti-CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function., PMID:40180777

IgG4-related disease: lessons from the first 20 years., PMID:40071397

Evaluating Rituximab Failure Rates in Neuromyelitis Optica Spectrum Disorder: A Nationwide Real-World Study From South Korea., PMID:40065454

Can Inebilizumab Change the Management of IgG4-Related Disease?, PMID:40057125

Neurite orientation dispersion and density imaging in myelin oligodendrocyte glycoprotein antibody-associated disease and neuromyelitis optica spectrum disorders., PMID:39955814

Inebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review., PMID:39872531

Autoimmune encephalitis: recovery, residual symptoms and predictors of long-term sequelae., PMID:39832911

Upper cervical spinal cord atrophy in MS: Sex, menopause, and neurodegeneration., PMID:39825669

MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique., PMID:39812824

Hyperreflective retinal foci are associated with retinal degeneration after optic neuritis in neuromyelitis optica spectrum disorders and multiple sclerosis., PMID:39790055

Inebilizumab shows promise for IgG4-RD., PMID:39663465

Cerebellar Involvement in Attacks of Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorder., PMID:39661938

First-in-Human Study of BAT4406F, an ADCC-Enhanced Fully Humanized Anti-CD20 Monoclonal Antibody in Patients With Neuromyelitis Optica Spectrum Disorders., PMID:39592888

Linking Downbeat Nystagmus and Aquaporin-4-Positive Neuromyelitis Optica: A Closer Look at Their Hidden Relationship., PMID:39564022

Neuromyelitis optica spectrum disorder with ultra-longitudinally extensive transverse myelitis: A case report and literature review., PMID:39559196

Inebilizumab for Treatment of IgG4-Related Disease., PMID:39541094

Recurrent late-onset neutropenia following treatment with different B cell-depleting strategies in multiple sclerosis., PMID:39515320

Usage status of biologics for the chronic treatment of optic neuritis in neuromyelitis optica spectrum disorders in Japan., PMID:39470886

Teprotumumab for the Treatment of Thyroid Eye Disease: Why Should We Keep Our Eyes "Wide Open"?-A Clinical and Pharmacovigilance Point of View., PMID:39452535

CD19: a promising target for systemic sclerosis., PMID:39421745

[Efficacy and Safety of Inebilizumab, an Anti-CD19 Monoclonal Antibody, for the Treatment of Neuromyelitis Optica Spectrum Disorder: Based on the N-MOmentum Trial]., PMID:39370840

B-cell Depletion Therapy in Pediatric Neuroinflammatory Disease., PMID:39259430

Rapid differentiation of MOGAD and MS after a single optic neuritis., PMID:39249105

Diagnostic Value of Inter-Eye Difference Metrics on OCT for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis., PMID:39231384

B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity., PMID:39222408

A rare adverse effect in inebilizumab therapy for neuromyelitis optica spectrum disorder: a case report., PMID:39072007

Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT)., PMID:39021565

Seizure-Related Falls and Near Falls in LGI1-IgG Autoimmune Encephalitis., PMID:38938695

Frequency of Asymptomatic Optic Nerve Enhancement in 203 Patients With MOG Antibody-Associated Disease., PMID:38924706

Clinical features and outcomes in primary nervous system histiocytic neoplasms., PMID:38902249

Longitudinal change of serum NfL as disease activity biomarker candidate in MOGAD: A descriptive cohort study., PMID:38901371

A case report of AQP4-IgG-seropositive refractory neuromyelitis optica spectrum disorder patient with Sjögren's syndrome and pancytopenia treated with inebilizumab., PMID:38899058

Comparison of inebilizumab or rituximab in addition to glucocorticoid therapy for neuromyelitis optica spectrum disorders., PMID:38895668

Sex as a predictor of clinical phenotype and determinant of immune response in IgG4-related disease: a retrospective study of patients fulfilling the American College of Rheumatology-European League Against Rheumatism classification criteria., PMID:38824935

B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases., PMID:38760099

Safety and efficacy of inebilizumab for the treatment of neuromyelitis optica spectrum disorder: end-of-study results from the open-label period of the N-MOmentum trial., PMID:38760098

Network Meta-analysis of Ravulizumab and Alternative Interventions for the Treatment of Neuromyelitis Optica Spectrum Disorder., PMID:38722571

Radiologic Lag and Brain MRI Lesion Dynamics During Attacks in MOG Antibody-Associated Disease., PMID:38710000

Case report: Transition from anti-CD20 therapy to inebilizumab for 14 cases of neuromyelitis optica spectrum disorder., PMID:38689876

Datasheet

Document Download

Research Grade Inebilizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Inebilizumab [DHD10802]
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