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Research Grade Reslizumab

Catalog #:   DHC13601 Specific References (99) DATASHEET
Host species: Humanized
Isotype: IgG4-nd
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC13601

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-nd

Clonality

Monoclonal

Target

IL5, B-cell differentiation factor I, IL-5, T-cell replacing factor, TRF, Eosinophil differentiation factor, Interleukin-5

Concentration

1.71 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05113

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CDP-835, JES1-39D10, SCH55700, CAS: 241473-69-8

Clone ID

Reslizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Reslizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma, PMID: 32034960

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials, PMID: 25736990

Reslizumab, PMID: 31643704

Reslizumab, PMID: 29999862

Reslizumab (Cinqair) [Internet], PMID: 29356467

Reslizumab in Eosinophilic Asthma: A Review, PMID: 28421429

Mabs for treating asthma: omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, PMID: 32401603

Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma: results from two phase 3, randomised, double-blind, placebo-controlled trials, PMID: 32066536

Reslizumab in the treatment of severe eosinophilic asthma: an update, PMID: 29554826

Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts, PMID: 27018175

Update on reslizumab for eosinophilic asthma, PMID: 26372797

Reslizumab: First Global Approval, PMID: 27125787

Reslizumab for Treating Asthma with Elevated Blood Eosinophils Inadequately Controlled by Inhaled Corticosteroids: An Evidence Review Group Perspective of a NICE Single Technology Appraisal, PMID: 29582406

The effectiveness of Reslizumab in severe asthma treatment: a real-world experience, PMID: 31861993

Efficacy of Reslizumab Treatment in Exacerbation-Prone Patients with Severe Eosinophilic Asthma, PMID: 32562877

Reslizumab in the treatment of inadequately controlled asthma in adults and adolescents with elevated blood eosinophils: clinical trial evidence and future prospects, PMID: 28683596

Reslizumab in the management of poorly controlled asthma: the data so far, PMID: 27621657

Efficacy of Intravenous Reslizumab in Oral Corticosteroid-Dependent Asthma, PMID: 31626990

Reslizumab: Maintenance treatment for eosinophilic asthma inadequately controlled on corticosteroids, PMID: 27458609

Reslizumab as add-on therapy in patients with refractory asthma, PMID: 32273395

Pharmacokinetic/pharmacodynamic profile of reslizumab in asthma, PMID: 29268638

New treatments for chronic urticaria, PMID: 31446134

Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives, PMID: 30147386

Anti-IL5 therapies for asthma, PMID: 28933516

Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine?, PMID: 28344579

Safety of Reslizumab in Uncontrolled Asthma with Eosinophilia: A Pooled Analysis from 6 Trials, PMID: 31404668

Safety of humanized monoclonal antibodies against IL-5 in asthma: focus on reslizumab, PMID: 29486600

Asthma in adults: Principles of treatment, PMID: 31690379

The efficacy and safety of reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: A systematic review and meta-analysis, PMID: 27435534

Reslizumab Compared with Benralizumab in Patients with Eosinophilic Asthma: A Systematic Literature Review and Network Meta-Analysis, PMID: 30217529

Efficacy of Reslizumab for Eosinophilic Esophagitis, PMID: 29985878

Update on new biologics for intractable eosinophilic asthma: impact of reslizumab, PMID: 29780238

Precision medicine in asthma: linking phenotypes to targeted treatments, PMID: 29036018

Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma - a systematic review and meta-analysis, PMID: 30533206

Diagnosis and Management of Asthma in Adults: A Review, PMID: 28719697

Effect of intravenously administered reslizumab on spirometric lung age in patients with moderate-to-severe eosinophilic asthma, PMID: 31262379

Reslizumab and mepolizumab for moderate-to-severe poorly controlled asthma: an indirect comparison meta-analysis, PMID: 31686556

Higher Binding Affinity and in vitro Potency of Reslizumab for Interleukin-5 Compared With Mepolizumab, PMID: 30661320

Clinical Outcomes and Health-Care Resource Use Associated With Reslizumab Treatment in Adults With Severe Eosinophilic Asthma in Real-World Practice, PMID: 33333058

Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab, PMID: 28915080

Molecular Targets for Biological Therapies of Severe Asthma, PMID: 33329598

Dupilumab for the treatment of asthma, PMID: 28085503

Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma, PMID: 25578680

Update in Asthma and Airway Inflammation 2018, PMID: 31026407

Biological therapies for eosinophilic asthma, PMID: 29938543

A cost-effectiveness analysis of reslizumab in the treatment of poorly controlled eosinophilic asthma, PMID: 30003833

[Clinical and economic analysis of Reslizumab use in the treatment of patients with severe allergic eosinophilic asthma], PMID: 32598589

Targeted Molecular Therapies in Allergy and Rhinology, PMID: 33138725

Cost-utility analysis of reslizumab for patients with severe eosinophilic asthma inadequately controlled with high-dose inhaled corticosteroids and long-acting β 2-agonists in South Korea, PMID: 30964365

Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Modeling of Weight-Based Intravenous Reslizumab Dosing, PMID: 32333684

Cost-effectiveness of mepolizumab vs anti-interleukin-5/5r biologic therapies for the treatment of adults with severe asthma with an eosinophilic phenotype: a Chilean healthcare system perspective., PMID:40528625

Steroid-sparing benefits of biologic use in hypereosinophilic syndrome and substantial disease burden across subtypes., PMID:40486501

Exploratory analysis of the economically justifiable price of reslizumab for asthma severe in Colombia., PMID:40481431

Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores., PMID:40470207

Biologic Therapies for Severe Asthma: Current Insights and Future Directions., PMID:40364184

Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines., PMID:40339609

New Therapeutic Challenges in Pediatric Gastroenterology: A Narrative Review., PMID:40281872

Efficacy of Biologics in Reducing Exacerbations Requiring Hospitalization or an Emergency Department Visit in Patients with Moderate or Severe, Uncontrolled Asthma., PMID:40261563

Severe Asthma and Active SARS-CoV-2 Infection: Insights into Biologics., PMID:40149651

Adverse effects of biologics used to treat asthma., PMID:40099886

Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis., PMID:40060399

Effectiveness of biological therapy in severe asthma: a retrospective real-world study., PMID:40047156

Results of personalized biological therapy in patients with chronic rhinosinusitis with nasal polyps and severe uncontrolled bronchial asthma - real-life study., PMID:40008473

Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma., PMID:39896201

Poor Agreement Among Asthma Specialists on the Choice and Timing of Initiation of a Biologic Treatment for Severe Asthma Patients., PMID:39864739

Use of Biologics to Treat Asthma during Pregnancy and Adverse Events in Pregnant Women and Newborns: A Global Pharmacovigilance Analysis., PMID:39827867

Impact of Smoking on Biological Treatment Response in Patients From the German Severe Asthma (GAN) Registry., PMID:39800060

Patient experience with eosinophilic esophagitis symptoms and impacts on daily life based on in-trial qualitative interviews., PMID:39777591

The Role of Bronchial Biopsy in the Prediction of Response to Biologic Therapy in Severe Uncontrolled Asthma: A Prospective Study., PMID:39742914

Imaging eosinophil secretory granules: From storage containers to active, immune responder organelles., PMID:39709031

Eosinophilic esophagitis., PMID:39702284

Caregiver worry about COVID-19 as a predictor of social mitigation behaviours and SARS-CoV-2 infection in a 12-city U.S. surveillance study of households with children., PMID:39697187

Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics., PMID:39672815

Biologics in allergology and clinical immunology: Update on therapies for atopic diseases, urticaria, and angioedema and on safety aspects focusing on hypersensitivity reactions., PMID:39600395

Off-Label Use of Monoclonal Antibodies for Eosinophilic Esophagitis in Humans: A Scoping Review., PMID:39595142

Drugs for asthma., PMID:39558440

Dupilumab Use in Patients With Hypereosinophilic Syndromes: A Multicenter Case Series and Review of the Literature., PMID:39515522

Disease Burden and Access to Biologic Therapy in Patients with Severe Asthma, 2017-2022: An Analysis of the International Severe Asthma Registry., PMID:39479509

Pharmacologic Treatment of Eosinophilic Esophagitis: Efficacious, Likely Efficacious, and Failed Drugs., PMID:39474328

Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents., PMID:39396109

Real-World Studies of Biologics for the Treatment of Moderate-to-Severe Asthma., PMID:39389721

Asthma Biologics: Lung Function, Steroid-Dependence, and Exacerbations., PMID:39389718

Biologics in Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis., PMID:39389714

Disproportionality analysis of reslizumab based on the FDA Adverse Event Reporting System., PMID:39381062

Efficacy of Biologics in NSAID-ERD: United Airways From the Nose to the Bronchi., PMID:39343299

Up-dosing of reslizumab in severe asthmatics with persistent sputum eosinophilia: A feasibility study., PMID:39286951

Temporal variation in the effectiveness of biologics in asthma: Effect modification by changing patient characteristics., PMID:39260678

Choosing the Right Biologic for the Right Patient With Severe Asthma., PMID:39245321

A comparison of the impact of anti-IL5/5r therapies in allergic versus non-allergic patients with severe eosinophilic asthma in a real-life setting., PMID:39235972

One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial., PMID:39233016

Amniotic fluid modifies esophageal epithelium differentiation and inflammatory responses., PMID:39189791

Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways., PMID:39158477

Induction of sustained remission and reversal of pathologic transcriptome achieved with tezepelumab in an adolescent with eosinophilic esophagitis., PMID:39134146

Comparative efficacy of biologics for patients with inadequately controlled asthma: A network meta-analysis., PMID:39091592

TH2 cell compensatory effect following benralizumab treatment for eosinophilic gastritis., PMID:39089335

Real-World Safety Profile of Biologic Drugs for Severe Uncontrolled Asthma: A Descriptive Analysis from the Spanish Pharmacovigilance Database., PMID:39064232

Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases., PMID:39062104

Losartan Treatment Reduces Esophageal Eosinophilic Inflammation in a Subset of Eosinophilic Esophagitis., PMID:39059581

Long-term durability between parent and child patient-reported outcomes in eosinophilic esophagitis., PMID:39059504

Datasheet

Document Download

Research Grade Reslizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Reslizumab [DHC13601]
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