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Research Grade Evolocumab

Catalog #:   DHJ24002 Specific References (100) DATASHEET
Host species: Human
Isotype: IgG2-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ24002

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2-lambda

Clonality

Monoclonal

Target

Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, NARC-1, PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, NARC1, PCSK9

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8NBP7

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG 145, Anti-PCSK9, CAS: 1256937-27-5

Clone ID

Evolocumab

Data Image
  • SDS-PAGE
    SDS PAGE for Evolocumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease, PMID: 28304224

Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia, PMID: 32865373

Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor, PMID: 29353350

Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia, PMID: 31648705

Evolocumab for Early Reduction of LDL Cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS), PMID: 31479722

Evolocumab: Considerations for the Management of Hyperlipidemia, PMID: 29511875

Effect of Evolocumab on Coronary Plaque Composition, PMID: 30336824

Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial, PMID: 28927706

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial, PMID: 27846344

Evolocumab in HIV-Infected Patients With Dyslipidemia: Primary Results of the Randomized, Double-Blind BEIJERINCK Study, PMID: 32234462

Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial, PMID: 28859947

A 52-week placebo-controlled trial of evolocumab in hyperlipidemia, PMID: 24678979

Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients With Peripheral Artery Disease: Insights From the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk), PMID: 29133605

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events, PMID: 25773607

A Systematic Review of PCSK9 Inhibitors Alirocumab and Evolocumab, PMID: 27231792

Evolocumab, PMID: 29999810

Long-Term Evolocumab in Patients With Familial Hypercholesterolemia, PMID: 32057369

Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization, PMID: 33197560

Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease: A Prespecified Analysis From the FOURIER Trial, PMID: 31116355

Cognition After Lowering LDL-Cholesterol With Evolocumab, PMID: 32381158

Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial, PMID: 27039291

Efficacy and Safety of Evolocumab in Chronic Kidney Disease in the FOURIER Trial, PMID: 31196453

Systematic Review and Network Meta-Analysis on the Efficacy of Evolocumab and Other Therapies for the Management of Lipid Levels in Hyperlipidemia, PMID: 28971955

Effect of Evolocumab on Atherogenic Lipoproteins During the Peri- and Early Postinfarction Period: A Placebo-Controlled, Randomized Trial, PMID: 32718248

Evolocumab in Children with Heterozygous Familial Hypercholesterolemia, PMID: 32997915

Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial, PMID: 24825642

Clinical Benefit of Evolocumab by Severity and Extent of Coronary Artery Disease: Analysis From FOURIER, PMID: 29626068

Cognitive Function in a Randomized Trial of Evolocumab, PMID: 28813214

Evolocumab: A Review in Hyperlipidemia, PMID: 26643308

Effect of Evolocumab on Type and Size of Subsequent Myocardial Infarction: A Prespecified Analysis of the FOURIER Randomized Clinical Trial, PMID: 32347885

Evolocumab reduces LDL-cholesterol levels in FH, PMID: 32913308

Effect of evolocumab therapy on coronary fibrous cap thickness assessed by optical coherence tomography in patients with acute coronary syndrome, PMID: 31495548

Evolocumab treatment in patients with HIV and hypercholesterolemia/mixed dyslipidemia: BEIJERINCK study design and baseline characteristics, PMID: 31841795

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis, PMID: 32312223

Effects of Evolocumab on Cardiovascular Events, PMID: 28925859

Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial, PMID: 31707849

Efficacy and Safety of PCSK9 Inhibition With Evolocumab in Reducing Cardiovascular Events in Patients With Metabolic Syndrome Receiving Statin Therapy: Secondary Analysis From the FOURIER Randomized Clinical Trial, PMID: 32785614

Comparison of PCSK9 Inhibitor Evolocumab vs Ezetimibe in Statin-Intolerant Patients: Design of the Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin-Intolerant Subjects 3 (GAUSS-3) Trial, PMID: 26946077

Preclinical discovery and development of evolocumab for the treatment of hypercholesterolemia, PMID: 31973581

Profile of evolocumab and its cost-effectiveness in patients with high cardiovascular risk: literature review, PMID: 30014724

Evolocumab: First Global Approval, PMID: 26323342

Patient adherence, compliance, and perspectives on evolocumab for the management of resistant hypercholesterolemia, PMID: 30464416

The efficacy of evolocumab in the management of hyperlipidemia: a systematic review, PMID: 28488460

Clinical Evaluation Of Evolocumab For The Treatment Of Homozygous Familial Hypercholesterolemia In Chinese Patients, PMID: 31686828

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial, PMID: 25282520

A safety evaluation of evolocumab, PMID: 28988500

Cost-effectiveness of Evolocumab, PMID: 30509368

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial, PMID: 25282519

[Evolocumab and PROFICIO Project: Initial Results], PMID: 26652783

Profile of evolocumab and its potential in the treatment of hyperlipidemia, PMID: 26109850

Alirocumab versus Evolocumab on Cardiovascular Outcomes: A Systematic Review and Meta-analysis., PMID:40511660

Statins Versus Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors for Primary Cardiovascular Prevention in High-Risk Patients: A Systematic Review., PMID:40486443

Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice., PMID:40462197

Association between novel agents targeting proprotein convertase subtilisin/kexin type 9 and cancer incidence., PMID:40447742

Impact of In-Hospital PCSK9 Inhibition on Myocardial Inflammation After Myocardial Infarction: A Randomized Clinical Trial., PMID:40439630

Impact of evolocumab on plaque phenotypic changes in patients with acute coronary syndrome and elevated lipoprotein(a) levels: a HUYGENS secondary analysis., PMID:40424182

Design of the "EAST" strategy in patients with symptomatic intracranial atherosclerotic stenosis., PMID:40417113

Efficacy and safety of evolocumab in statin-treated patients with cardiovascular risk factors: a systematic review and meta-analysis., PMID:40402652

A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis., PMID:40394654

Clinical benefits of evolocumab in diabetic patients with STEMI undergoing PCI: a retrospective study., PMID:40385035

Improvement of retinal microvascular function after initiation of lipid-lowering therapy with PCSK9 inhibitors - An observational study., PMID:40360377

Comparative Efficacy of Non-Statin Lipid-Lowering Therapies in Patients With Hypercholesterolemia at Increased Cardiovascular Risk: An Updated Network Meta-Analysis., PMID:40358978

Evolocumab Versus Statins and Placebo in Patients With Cardiovascular Disease and Comorbidities: A Systematic Review and Meta-Analysis., PMID:40351996

Effects of Alirocumab and Evolocumab on Cardiovascular Mortality and LDL-C: Stratified According to the Baseline LDL-C Levels., PMID:40351695

[Huotan Jiedu Tongluo Decoction inhibits ferroptosis by regulating Nrf2/GPX4 pathway to ameliorate atherosclerotic lesions in ApoE~(-/-) mice]., PMID:40350883

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: A drug-target Mendelian randomization study., PMID:40347490

Proprotein convertase subtilisin/kexin type 9 contributes to cisplatin-induced acute kidney injury by interacting with cyclase-associated protein 1 to promote megalin lysosomal degradation., PMID:40339661

Effectiveness of alirocumab and evolocumab (PCSK9i) for the treatment of hypercholesterolemia., PMID:40339450

Expanding Our Understanding of Plaque Stabilization With PCSK9 Inhibitors., PMID:40335216

Cost-Effectiveness Analysis of Evolocumab or Inclisiran in Combination with Statins Versus Statin Monotherapy Among Patients with ASCVD in China., PMID:40323561

Hypercholesterolemia and cardiovascular disease: the dilemma of effective treatment for target achievement according to guidelines and national healthcare policies and a call to action., PMID:40322779

LDL-C Reduction with Evolocumab Among Patients with ASCVD in China: Real-World Evidence from Tianjin Metropolitan Area., PMID:40279014

Intensive Lowering of LDL Cholesterol Levels With Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial., PMID:40255182

Inadequate Response to PCSK9 Inhibitors., PMID:40250948

Consumption and expenditure of drugs used for the treatment of hypercholesterolemia: a governance analysis., PMID:40222896

Effect of PCSK9 inhibitor usage on coronary endothelial dysfunction in patients with hypercholesterolemia after coronary stenting: The CuVIC-2 trial., PMID:40221085

Safety and effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition: an updated review., PMID:40202526

Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography., PMID:40178463

Effects of residual inflammatory and cholesterol risks on cardiovascular events with evolocumab in patients with acute coronary syndrome undergoing percutaneous coronary intervention., PMID:40165297

Importance of Genotype-Phenotype Correlation in the Population Screening of Familial Hypercholesterolemia., PMID:40125198

Body Mass Index, Comorbidities, and Ambulatory Care Visits: The REGARDS Study., PMID:40118809

Rethinking Cardiovascular Prevention: Cost-Effective Cholesterol Lowering for Statin-Intolerant Patients in Australia and the UK., PMID:40112156

Serum Lipids, Inflammation, and the Risk of Atrial Fibrillation: Pathophysiological Links and Clinical Evidence., PMID:40095683

Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan., PMID:40089775

Evolocumab ameliorates myocardial fibrosis and improves metabolic syndrome-induced cardiac dysfunction in rats via inhibiting PCSK9/NLRP3 inflammasome and Caspase-1 / IL-1β pathways., PMID:40064223

Effects of Inclisiran, Alirocumab, Evolocumab, and Evinacumab on Lipids: A Network Meta-Analysis., PMID:40026525

Dramatic response to Evinacumab in a North Indian girl with homozygous familial hypercholesterolemia., PMID:40022592

Achieved levels of apolipoprotein B and plaque composition after acute coronary syndromes: Insights from HUYGENS., PMID:40020597

Patient with Vulnerable Coronary Plaque and Treatment with Evolocumab: A Clinical Case., PMID:40004789

Treatment with PCSK9 inhibitors influences microRNAs expression and changes of arterial wall properties: a randomized controlled trial., PMID:40001082

Administration of Evolocumab in Patients with STEMI After Emergency PCI: A Real-World Cohort Study., PMID:39992584

Evolocumab Reduces Oxidative Stress and Lipid Peroxidation in Obese Zucker Rats., PMID:39982361

In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss., PMID:39979532

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis., PMID:39975967

Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte?, PMID:39947256

PCSK9 Expression in Vascular Smooth Muscle Cells: Role of Insulin Resistance and High Glucose., PMID:39940773

Popliteal Artery Rupture: A Rare but Life-Threatening Complication of Total Knee Arthroplasty., PMID:39935650

Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report., PMID:39931866

Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes., PMID:39930254

Evolocumab induced short-term biliary stent blockage and acute cholangitis in a jaundice patient with pancreatic carcinoma: a rare complication of PCSK9 inhibitor., PMID:39925901

Datasheet

Document Download

Research Grade Evolocumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Evolocumab [DHJ24002]
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