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Research Grade Dinutuximab (DGK07801)

Host species:Chimeric
Isotype:IgG1-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DGK07801

Expression system

Mammalian Cells

Species reactivity

General

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Ganglioside GD2

Concentration

1.3 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 65988-71-8

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

14.18, MAb-14.18, MOAB Ch14.18, CAS: 1363687-32-4, DGK07804

Clone ID

Dinutuximab

Data Image
  • SDS-PAGE
    SDS PAGE for Dinutuximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Dinutuximab beta for neuroblastoma, PMID: 33363307

Dinutuximab, PMID: 29999821

Dinutuximab, PMID: 31644006

Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial, PMID: 28549783

The safety of dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma, PMID: 30433831

Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial, PMID: 30442501

Dinutuximab for maintenance therapy in pediatric neuroblastoma, PMID: 28389455

Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group, PMID: 32343642

Dinutuximab: An Anti-GD2 Monoclonal Antibody for High-Risk Neuroblastoma, PMID: 26917818

Dinutuximab: A Review in High-Risk Neuroblastoma, PMID: 26891967

Dinutuximab: first global approval, PMID: 25940913

Dinutuximab Beta for Treating Neuroblastoma: An Evidence Review Group and Decision Support Unit Perspective of a NICE Single Technology Appraisal, PMID: 30465228

Spotlight on dinutuximab in the treatment of high-risk neuroblastoma: development and place in therapy, PMID: 30613134

Overview and recent advances in the treatment of neuroblastoma, PMID: 28142287

Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1), PMID: 32013055

Local delivery of dinutuximab from lyophilized silk fibroin foams for treatment of an orthotopic neuroblastoma model, PMID: 32096344

Dinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma, PMID: 32356686

Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway, PMID: 32440155

Dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma, PMID: 26934530

Dinutuximab and Panobinostat, PMID: 26912916

GD2 targeting by dinutuximab beta is a promising immunotherapeutic approach against malignant glioma, PMID: 32246395

Dinutuximab for the treatment of pediatric patients with neuroblastoma, PMID: 29238760

Implementation of immunotherapy into the treatment of neuroblastoma - single center experience with the administration of dinutuximab and management of its adverse effects, PMID: 33108882

Nivolumab and dinutuximab beta in two patients with refractory neuroblastoma, PMID: 32414861

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma, PMID: 20879881

Initiation of immunotherapy with activated natural killer cells and anti-GD2 antibody dinutuximab prior to resection of primary neuroblastoma prolongs survival in mice, PMID: 33428582

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy, PMID: 32733795

Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death, PMID: 33252182

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry, PMID: 29938370

PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective, PMID: 29196189

Tolerance of dinutuximab therapy for treatment of high-risk neuroblastoma in two patients with end-stage renal disease on dialysis, PMID: 33381917

Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing, PMID: 32342128

Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma, PMID: 30232225

The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology, PMID: 33341446

A Case of Anti-NMDA Receptor Encephalitis During Dinutuximab Therapy for Neuroblastoma, PMID: 31651725

Dinutuximab approved for high-risk neuroblastoma, PMID: 25851859

Optimizing care for high-risk neuroblastoma patients treated with dinutuximab: Challenges for the multidisciplinary team, PMID: 32660378

Extensive small bowel pneumatosis and ischemia during dinutuximab therapy for high-risk neuroblastoma, PMID: 31925911

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force, PMID: 31031965

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2 + breast cancer stem-like cells, PMID: 33722905

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma, PMID: 32653773

Impact of IL-2 on Treatment Tolerance in Patients With High-Risk Neuroblastoma Treated With Dinutuximab Beta-Based Immunotherapy, PMID: 33392114

In brief: Dinutuximab (Unituxin) for high-risk neuroblastoma, PMID: 27027692

Dinutuximab: A Novel Immunotherapy in the Treatment of Pediatric Patients With High-Risk Neuroblastoma [Formula: see text], PMID: 27456981

Edoxaban, PMID: 26445907

Treatment and survival of childhood neuroblastoma: Evidence from a population-based study in the United States, PMID: 29039999

The Role of Nursing Professionals in the Management of Patients With High-Risk Neuroblastoma Receiving Dinutuximab Therapy, PMID: 28061552

GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma, PMID: 33303017

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment, PMID: 34049929

A Phase I/IIa Study of Antidisialoganglioside Antibody Dinutuximab in Japanese Patients With Neuroblastoma, PMID: 31815885

Datasheet

Document Download

Research Grade Dinutuximab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Dinutuximab [DGK07801]
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