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Research Grade Dinutuximab

Catalog #:   DGK07801 Specific References (99) DATASHEET
Host species: Chimeric
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DGK07801

Expression system

Mammalian Cells

Species reactivity

General

Host species

Chimeric

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Ganglioside GD2

Concentration

4 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

CAS: 65988-71-8

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

14.18, MAb-14.18, MOAB Ch14.18, CAS: 1363687-32-4, DGK07804

Clone ID

Dinutuximab

Data Image
  • SDS-PAGE
    SDS PAGE for Dinutuximab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Dinutuximab beta for neuroblastoma, PMID: 33363307

Dinutuximab, PMID: 29999821

Dinutuximab, PMID: 31644006

Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial, PMID: 28549783

The safety of dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma, PMID: 30433831

Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial, PMID: 30442501

Dinutuximab for maintenance therapy in pediatric neuroblastoma, PMID: 28389455

Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group, PMID: 32343642

Dinutuximab: An Anti-GD2 Monoclonal Antibody for High-Risk Neuroblastoma, PMID: 26917818

Dinutuximab: A Review in High-Risk Neuroblastoma, PMID: 26891967

Dinutuximab: first global approval, PMID: 25940913

Dinutuximab Beta for Treating Neuroblastoma: An Evidence Review Group and Decision Support Unit Perspective of a NICE Single Technology Appraisal, PMID: 30465228

Spotlight on dinutuximab in the treatment of high-risk neuroblastoma: development and place in therapy, PMID: 30613134

Overview and recent advances in the treatment of neuroblastoma, PMID: 28142287

Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1), PMID: 32013055

Local delivery of dinutuximab from lyophilized silk fibroin foams for treatment of an orthotopic neuroblastoma model, PMID: 32096344

Dinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma, PMID: 32356686

Dinutuximab Synergistically Enhances the Cytotoxicity of Natural Killer Cells to Retinoblastoma Through the Perforin-Granzyme B Pathway, PMID: 32440155

Dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma, PMID: 26934530

Dinutuximab and Panobinostat, PMID: 26912916

GD2 targeting by dinutuximab beta is a promising immunotherapeutic approach against malignant glioma, PMID: 32246395

Dinutuximab for the treatment of pediatric patients with neuroblastoma, PMID: 29238760

Implementation of immunotherapy into the treatment of neuroblastoma - single center experience with the administration of dinutuximab and management of its adverse effects, PMID: 33108882

Nivolumab and dinutuximab beta in two patients with refractory neuroblastoma, PMID: 32414861

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma, PMID: 20879881

Initiation of immunotherapy with activated natural killer cells and anti-GD2 antibody dinutuximab prior to resection of primary neuroblastoma prolongs survival in mice, PMID: 33428582

Disialoganglioside GD2 Expression in Solid Tumors and Role as a Target for Cancer Therapy, PMID: 32733795

Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death, PMID: 33252182

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry, PMID: 29938370

PD-L1, inflammation, non-coding RNAs, and neuroblastoma: Immuno-oncology perspective, PMID: 29196189

Tolerance of dinutuximab therapy for treatment of high-risk neuroblastoma in two patients with end-stage renal disease on dialysis, PMID: 33381917

Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing, PMID: 32342128

Activated Natural Killer Cells in Combination with Anti-GD2 Antibody Dinutuximab Improve Survival of Mice after Surgical Resection of Primary Neuroblastoma, PMID: 30232225

The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology, PMID: 33341446

A Case of Anti-NMDA Receptor Encephalitis During Dinutuximab Therapy for Neuroblastoma, PMID: 31651725

Dinutuximab approved for high-risk neuroblastoma, PMID: 25851859

Optimizing care for high-risk neuroblastoma patients treated with dinutuximab: Challenges for the multidisciplinary team, PMID: 32660378

Extensive small bowel pneumatosis and ischemia during dinutuximab therapy for high-risk neuroblastoma, PMID: 31925911

Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force, PMID: 31031965

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2 + breast cancer stem-like cells, PMID: 33722905

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma, PMID: 32653773

Impact of IL-2 on Treatment Tolerance in Patients With High-Risk Neuroblastoma Treated With Dinutuximab Beta-Based Immunotherapy, PMID: 33392114

In brief: Dinutuximab (Unituxin) for high-risk neuroblastoma, PMID: 27027692

Dinutuximab: A Novel Immunotherapy in the Treatment of Pediatric Patients With High-Risk Neuroblastoma [Formula: see text], PMID: 27456981

Edoxaban, PMID: 26445907

Treatment and survival of childhood neuroblastoma: Evidence from a population-based study in the United States, PMID: 29039999

The Role of Nursing Professionals in the Management of Patients With High-Risk Neuroblastoma Receiving Dinutuximab Therapy, PMID: 28061552

GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma, PMID: 33303017

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment, PMID: 34049929

A Phase I/IIa Study of Antidisialoganglioside Antibody Dinutuximab in Japanese Patients With Neuroblastoma, PMID: 31815885

Single-Center Cohort of Pediatric Patients with High-Risk Neuroblastoma Receiving Immunotherapy., PMID:40507305

Efficacy and Safety of Anti-GD2 Immunotherapy with Dinutuximab Beta in the Treatment of Relapsed/Refractory High-Risk Neuroblastoma., PMID:40459700

Advancements in neuroblastoma treatment: FDA-approved drugs and role of phytochemicals., PMID:40442345

Autophagy inhibition amplifies anti-tumor immunity effect of dinutuximab beta on neuroblastoma via the VEGFR/AKT/mTOR and ROS/NF-κB pathways., PMID:40378433

Ocular Toxicity in GD-2 Antibody Therapy: A Case Study., PMID:40247734

A comprehensive clinico-pathological review of a series of pediatric, adolescents and young adults with high-grade osteosarcoma: from clinics to biomarker discovery., PMID:40198505

A clinical observational study of dinutuximab beta as first-line maintenance treatment for patients with high-risk neuroblastoma in China., PMID:40091019

Management and outcome of children with high-risk neuroblastoma: insights from the Spanish Society of Pediatric Hematology and Oncology (SEHOP) neuroblastoma group on refractory and relapse/progressive disease., PMID:39998749

PHOX2B -associated Congenital Central Hypoventilation Syndrome Revealed Upon Treatment With Dinutuximab-beta., PMID:39961018

Post Transplant Outcomes of High-Risk Neuroblastoma From a Tertiary Care Unit in India., PMID:39912276

Strategies to manage the adverse effects of immunotherapy with dinutuximab beta in neuroblastoma: an Italian experience and literature review., PMID:39907793

Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-ICU Setting., PMID:39867536

131I-mIBG therapy in relapsed/refractory neuroblastoma: A weapon from the future past., PMID:39732302

Prospects of anti-GD2 immunotherapy for retinoblastoma., PMID:39620227

Iwilfin (eflornithine) approved by the FDA as the first and only oral maintenance therapy for high-risk neuroblastoma in adult and pediatric patients: Narrative review., PMID:39612452

Case Report of Dinutuximab-induced Atypical Hemolytic Uremic Syndrome., PMID:39530431

GD2 in Breast Cancer: A Potential Biomarker and Therapeutic Target., PMID:39467630

Local Sustained Dinutuximab Delivery and Release From Methacrylated Chondroitin Sulfate., PMID:39359103

Safety and outcome of children, adolescents and young adults participating in phase I/II clinical oncology trials: a 9-year center experience., PMID:39318620

Current Knowledge and Perspectives of Immunotherapies for Neuroblastoma., PMID:39199637

Patterns of recurrence after radiotherapy for high-risk neuroblastoma: Implications for radiation dose and field., PMID:38880415

Targeting both GD2 and B7-H3 using bispecific antibody improves tumor selectivity for GD2-positive tumors., PMID:38853889

Enhancing IgA-mediated neutrophil cytotoxicity against neuroblastoma by CD47 blockade., PMID:38782540

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells., PMID:38736882

Autologous hematopoietic stem cell transplantation followed by quadruple immunotherapy with dinutuximab beta, sargramostim, aldesleukin, and spironolactone for relapsed metastatic retinoblastoma., PMID:38679862

Choosing T-cell sources determines CAR-T cell activity in neuroblastoma., PMID:38601159

ECLIM-SEHOP: how to develop a platform to conduct academic trials for childhood cancer., PMID:38600340

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma., PMID:38581035

Chemo-immunotherapy with dinutuximab beta in patients with relapsed/progressive high-risk neuroblastoma: does chemotherapy backbone matter?, PMID:38489858

Bilateral tonic pupils secondary to anti-GD2 antibody therapy for neuroblastoma., PMID:38368925

A novel approach to guide GD2-targeted therapy in pediatric tumors by PET and [64Cu]Cu-NOTA-ch14.18/CHO., PMID:38323317

Targeted therapies in retinoblastoma: GD2-directed immunotherapy following autologous stem cell transplantation and evaluation of alternative target B7-H3., PMID:38240863

Persistence of Racial and Ethnic Disparities in Risk and Survival for Patients with Neuroblastoma over Two Decades., PMID:38213818

Yoga as a non-pharmacologic therapy to reduce dinutuximab-induced pain in patients with neuroblastoma., PMID:38192171

Bevacizumab, Irinotecan, or Topotecan Added to Temozolomide for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON-Neuroblastoma Trial., PMID:38190578

Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System., PMID:38153627

Safety and efficacy of dinutuximab in the treatment of neuroblastoma: A review., PMID:38116487

GM-CSF, G-CSF or no cytokine therapy with anti-GD2 immunotherapy for high-risk neuroblastoma., PMID:38108214

Late Relapse in Neuroblastoma: Case Report and Review of the Literature., PMID:37929737

Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons., PMID:37883734

A Multi-Color Flow Cytometric Assay for Quantifying Dinutuximab Binding to Neuroblastoma Cells in Tumor, Bone Marrow, and Blood., PMID:37834874

Multimodal Therapy with Consolidating Haploidentical Stem Cell Transplantation and Dinutuximab Beta for Patients with High-Risk Neuroblastoma and Central Nervous System Relapse., PMID:37834840

Long-term, continuous infusion of single-agent dinutuximab beta for relapsed/refractory neuroblastoma: an open-label, single-arm, Phase 2 study., PMID:37813959

Exploring dual effects of dinutuximab beta on cell death and proliferation of insulinoma., PMID:37802653

Treatment of High-Risk Neuroblastoma with Dinutuximab and Chemotherapy Administered in all Cycles of Induction., PMID:37760578

Targeting GD2 after allogeneic SCT: effector cell composition defines the optimal use of ch14.18 and the bispecific antibody construct NG-CU (GD2-CD3)., PMID:37742286

Cost-effectiveness analysis of dinutuximab β for the treatment of high-risk neuroblastoma in China., PMID:37715719

Dinutuximab Beta Maintenance Therapy in Patients with High-Risk Neuroblastoma in First-Line and Refractory/Relapsed Settings-Real-World Data., PMID:37629294

The yes-associated protein (YAP) is associated with resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1., PMID:37554309

Datasheet

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Research Grade Dinutuximab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Dinutuximab [DGK07801]
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