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Research Grade Blinatumomab

Catalog #:   DHD10804 Specific References (100) DATASHEET
Host species: Mouse
Isotype: (scFv-kappa-heavy)-(scFv-heavy-kappa)
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD10804

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Mouse

Isotype

(scFv-kappa-heavy)-(scFv-heavy-kappa)

Clonality

Monoclonal

Target

CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Concentration

1.61 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Accession

P15391 & P07766

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

9mM Citric acid, 41mM Na2HPO4, 1% mannitol, 5%trehalose, 0.02% Tween20, pH6.5

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Bispecific, CD19, AMG103, BITE MT-103, MEDI-538, MT103, bscCD19xCD3, CAS: 853426-35-4

Clone ID

Blinatumomab

Data Image
  • SDS-PAGE
    SDS PAGE for Blinatumomab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia, PMID: 28249141

Dasatinib-Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults, PMID: 33085860

Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia, PMID: 29358182

A review of blinatumomab, a novel immunotherapy, PMID: 26607163

Blinatumomab: a CD19/CD3 bispecific T cell engager (BiTE) with unique anti-tumor efficacy, PMID: 27050240

Evaluating Blinatumomab for the Treatment of Relapsed/Refractory ALL: Design, Development, and Place in Therapy, PMID: 33173373

Recent advances on blinatumomab for acute lymphoblastic leukemia, PMID: 31709129

Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia, PMID: 27998223

Taking a "BiTE out of ALL": blinatumomab approval for MRD-positive ALL, PMID: 30796026

Blinatumomab for infant acute lymphoblastic leukemia, PMID: 32043146

Benefit-Risk Assessment of Blinatumomab in the Treatment of Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia, PMID: 30565020

Blinatumomab-Associated Neurological Adverse Events, PMID: 32902938

Blinatumomab, PMID: 31643524

Blinatumomab + ponatinib for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia in adults, PMID: 33153370

Blinatumomab: a historical perspective, PMID: 22940266

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study, PMID: 25524800

Blinatumomab, PMID: 29999804

How we infuse blinatumomab, PMID: 32573958

Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia, PMID: 31626339

Role of blinatumomab, inotuzumab, and CAR T-cells: Which to choose and how to sequence for patients with relapsed disease, PMID: 33256906

Blinatumomab versus chemotherapy in first salvage or in later salvage for B-cell precursor acute lymphoblastic leukemia, PMID: 30947585

Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL, PMID: 32881995

Blinatumomab for Acute Lymphoblastic Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation, PMID: 31002989

Transplantation in adults with relapsed/refractory acute lymphoblastic leukemia who are treated with blinatumomab from a phase 3 study, PMID: 31433496

Blinatumomab versus historical standard therapy in pediatric patients with relapsed/refractory Ph-negative B-cell precursor acute lymphoblastic leukemia, PMID: 32094465

Clinical utilization of blinatumomab and inotuzumab immunotherapy in children with relapsed or refractory B-acute lymphoblastic leukemia, PMID: 33098744

Long-term survival of patients with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab, PMID: 33141929

Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma, PMID: 26755709

Chemoimmunotherapy with inotuzumab ozogamicin combined with mini-hyper-CVD, with or without blinatumomab, is highly effective in patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first salvage, PMID: 30307611

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia, PMID: 32619115

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy, PMID: 31738832

Blinatumomab administered concurrently with oral tyrosine kinase inhibitor therapy is a well-tolerated consolidation strategy and eradicates measurable residual disease in adults with Philadelphia chromosome positive acute lymphoblastic leukemia, PMID: 30831480

Blinatumomab for the Treatment of Adult B-Cell Acute Lymphoblastic Leukemia: Toward a New Era of Targeted Immunotherapy, PMID: 32103893

Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy, PMID: 23678006

Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma: Final Results From a Phase I Study, PMID: 26884582

Blinatumomab, a Bispecific T-cell Engager (BiTE(®)) for CD-19 Targeted Cancer Immunotherapy: Clinical Pharmacology and Its Implications, PMID: 27209293

Blinatumomab for the treatment of B-cell lymphoma, PMID: 25739952

Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis, PMID: 30985931

Blinatumomab for lymphoblastic leukaemia, PMID: 27990053

Correlates of resistance and relapse during blinatumomab therapy for relapsed/refractory acute lymphoblastic leukemia, PMID: 28494518

Blinatumomab: first global approval, PMID: 25637301

Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies, PMID: 30380973

Safety and Efficacy of Blinatumomab in Combination With a Tyrosine Kinase Inhibitor for the Treatment of Relapsed Philadelphia Chromosome-positive Leukemia, PMID: 28927784

Blinatumomab: A novel, bispecific, T-cell engaging antibody, PMID: 26683683

Targeting non-Hodgkin lymphoma with blinatumomab, PMID: 28532177

Complete Hematologic and Molecular Response in Adult Patients With Relapsed/Refractory Philadelphia Chromosome-Positive B-Precursor Acute Lymphoblastic Leukemia Following Treatment With Blinatumomab: Results From a Phase II, Single-Arm, Multicenter Study, PMID: 28355115

Pediatric blinatumomab preparation: Risk assessment on SmPC for software compliance, PMID: 33106105

Blinatumomab for the treatment of acute lymphoblastic leukemia, PMID: 26383529

Blinatumomab provoked fatal heart failure, PMID: 27816725

Blinatumomab-associated vasculitis, PMID: 28879223

Outcome of second allogeneic hematopoietic cell transplantation in adult patients with relapsed B-cell acute lymphoblastic leukemia in the era of new immunotherapeutic agents., PMID:40527981

Successful treatment with decompressive laparotomy for abdominal compartment syndrome induced by asparaginase-associated pancreatitis in a pediatric patient with acute lymphoblastic leukemia: a case report., PMID:40519724

Pooled biomarker analysis of the association of baseline T regulatory cells with response and T-cell recovery profiles with blinatumomab treatment., PMID:40515477

From Molecular Precision to Clinical Practice: A Comprehensive Review of Bispecific and Trispecific Antibodies in Hematologic Malignancies., PMID:40508128

Blinatumomab and better BCR::ABL1 inhibition begets better bone marrow transplant outcomes., PMID:40501389

Comparing Outcomes of First-Line Intensive Chemotherapeutic Regimens in Adult Patients With Acute Lymphoblastic Leukemia at a Tertiary Center., PMID:40500615

Blinatumomab in Childhood B-Cell Acute Lymphoblastic Leukemia. Reply., PMID:40499182

Blinatumomab in Childhood B-Cell Acute Lymphoblastic Leukemia., PMID:40499181

Treatment of Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia., PMID:40494331

The integration of blinatumomab consolidation in the CALGB 10403 regimen for adults with B-cell precursor acute lymphoblastic leukaemia in measurable residual disease-negative remission., PMID:40492422

Blinatumomab Use in Pediatric B-ALL: Where are we now?, PMID:40489801

Acute Lymphoid Leukemia: Is Transplant Indicated for Philadelphia Chromosome Positive ALL?, PMID:40488828

High sensitivity charge heterogeneity characterization of blinatumomab product by imaged capillary isoelectric focusing with native UV fluorescence detection., PMID:40483960

Recent advances in monoclonal antibody development for treatment of B-cell acute lymphoblastic leukemia., PMID:40455243

Multi-courses of blinatumomab combined with reduced dose chemotherapy has been successfully used in chemo-intolerant middle to high-risk pediatric B-ALL patients with invasive fungal disease., PMID:40445300

Revumenib for Relapsed or Refractory Acute Leukemia With a KMT2A Translocation., PMID:40437770

Blinatumomab Versus Chemotherapy for Post-Induction Consolidation in First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials., PMID:40436683

Navigating B-ALL in the Era of Blinatumomab., PMID:40435433

Efficacy and safety of blinatumomab in Chinese patients with relapsed/refractory B-cell acute lymphoblastic leukemia: a single-center retrospective study., PMID:40421088

Acute Pancreatitis Associated With Blinatumomab Treatment in a Patient With Acute Lymphoblastic Leukemia., PMID:40406756

Blitzing ALL with blinatumomab., PMID:40402527

Adult Acute Lymphoblastic Leukemia: 2025 Update on Diagnosis, Therapy, and Monitoring., PMID:40377367

Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia with e13a3 fusion transcripts in a patient with pre-existing essential thrombocythemia: a case report and literature review., PMID:40376591

Rituximab efficacy for minimal residual disease eradication in philadelphia-negative acute lymphoblastic leukemia CD20., PMID:40374821

Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab., PMID:40369607

The role of blinatumomab in adult acute B lymphoblastic leukaemia., PMID:40368871

[Clinical analysis of 16 cases of adult acute B-lymphoblastic leukemia treated with blinatumomab]., PMID:40355357

Treatment of Older Patients With ALL., PMID:40354595

Overcoming Chemotherapy Resistance in EBF1-PDGFRB-Positive B-ALL: A Novel Therapeutic Approach Using Dasatinib and Blinatumomab., PMID:40350550

The Role of Transplant for Philadelphia-positive B-cell Acute Lymphoblastic Leukemia in 2025., PMID:40343686

Beyond Cellular Therapies: The Expanding Role of Antibody-Driven Immunotherapy in Pediatric Acute Lymphoblastic Leukemia., PMID:40324358

The evolving therapeutic revolution in adult acute lymphoblastic leukemia., PMID:40323723

Recent development in bispecific antibody immunotherapy for hematological malignancies., PMID:40320222

Feedback-responsive cell factories for dynamic modulation of the unfolded protein response., PMID:40316547

Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy., PMID:40316226

Management of Adult Acute Lymphoblastic Leukemia: A Review., PMID:40310617

Pre-transplant blinatumomab and/or inotuzumab ozogamicin therapy for relapsed/refractory acute lymphoblastic and B/myeloid mixed phenotype acute leukemia in adults., PMID:40306011

Truncated form of human CD19 antigen as a suicide gene to control T-cell alloreactivity: ΔCD19., PMID:40304059

Tyrosine kinase inhibitors with blinatumomab versus chemotherapy in Philadelphia-positive acute B-lymphoblastic leukemia., PMID:40304038

Bispecific antibodies in immunotherapy for acute leukemia: latest updates from the 66th annual meeting of the American society of hematology, 2024., PMID:40270605

T-cell dysfunction during blinatumomab therapy in pediatric acute lymphoblastic leukemia., PMID:40267221

Differences in response to immunotherapy drugs including blinatumomab and inotuzumab ozogamicin in B-ALL patients., PMID:40232601

Improved post-transplant outcomes since 2000 for Ph-positive acute lymphoblastic leukemia in first remission: A study from the EBMT Acute Leukemia Working Party., PMID:40224161

Inferior Outcomes in Acute Lymphoblastic Leukemia With Translocation (14;18)., PMID:40222876

KMT2A-rearranged acute lymphoblastic leukemia in infants: current progress and challenges., PMID:40207717

Blinatumomab in combination with olverembatinib and concurrent intrathecal chemotherapy successfully treated a chronic myeloid leukemia relapse with central nervous system blast crisis: case report and literature review., PMID:40202540

Characteristics of second primary malignancies following bispecific antibodies therapy., PMID:40187754

Efficacy and safety comparison of CAR-T and blinatumomab immunotherapy as bridge-to-transplant strategies in relapsed/refractory B cell acute lymphoblastic leukemia., PMID:40181350

B-cell Acute Lymphoblastic Leukemia Presenting as Acute Liver Injury: A Case Report., PMID:40171360

Integrating Blinatumomab in the Frontline Treatment in B-Cell Acute Lymphoblastic Leukemia: A New Era in Therapeutic Management., PMID:40142863

Datasheet

Document Download

Research Grade Blinatumomab.pdf

 

$ 484
Product specifications
100 μg 484 1 mg 1932

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Research Grade Blinatumomab [DHD10804]
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